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Research ArticleNEURODEGENERATIVE DISORDER IMAGING

Neurofilament Light Chain Levels Interact with Neurodegenerative Patterns and Motor Neuron Dysfunction in Amyotrophic Lateral Sclerosis

Penelope Tilsley, Antoine Moutiez, Alexandre Brodovitch, Mohamed Mounir El Mendili, Benoit Testud, Wafaa Zaaraoui, Annie Verschueren, Shahram Attarian, Maxime Guye, José Boucraut, Aude-Marie Grapperon and Jan-Patrick Stellmann
American Journal of Neuroradiology March 2024, DOI: https://doi.org/10.3174/ajnr.A8154
Penelope Tilsley
aFrom the Centre de Résonance Magnétique Biologique et Médicale (P.T., M.M.E.M., B.T., W.Z., A.V., M.G., A.-M.G., J.-P.S.), Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France
bAssistance Publique-Marseille Hospitals (P.T., M.M.E.M., B.T., W.Z., M.G., J.-P.S.), Hôpital de la Timone, CEMEREM, Marseille, France
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  • ORCID record for Penelope Tilsley
Antoine Moutiez
cDepartment of Neuroradiology (A.M., B.T., J.-P.S.), Assistance Publique-Marseille Hospitals, Hôpital de la Timone, Marseille, France
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Alexandre Brodovitch
dImmunology Laboratory (A.B., J.B.), Assistance Publique-Marseille Hospitals, Conception Hospital, Marseille, France
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Mohamed Mounir El Mendili
aFrom the Centre de Résonance Magnétique Biologique et Médicale (P.T., M.M.E.M., B.T., W.Z., A.V., M.G., A.-M.G., J.-P.S.), Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France
bAssistance Publique-Marseille Hospitals (P.T., M.M.E.M., B.T., W.Z., M.G., J.-P.S.), Hôpital de la Timone, CEMEREM, Marseille, France
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Benoit Testud
aFrom the Centre de Résonance Magnétique Biologique et Médicale (P.T., M.M.E.M., B.T., W.Z., A.V., M.G., A.-M.G., J.-P.S.), Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France
bAssistance Publique-Marseille Hospitals (P.T., M.M.E.M., B.T., W.Z., M.G., J.-P.S.), Hôpital de la Timone, CEMEREM, Marseille, France
cDepartment of Neuroradiology (A.M., B.T., J.-P.S.), Assistance Publique-Marseille Hospitals, Hôpital de la Timone, Marseille, France
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Wafaa Zaaraoui
aFrom the Centre de Résonance Magnétique Biologique et Médicale (P.T., M.M.E.M., B.T., W.Z., A.V., M.G., A.-M.G., J.-P.S.), Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France
bAssistance Publique-Marseille Hospitals (P.T., M.M.E.M., B.T., W.Z., M.G., J.-P.S.), Hôpital de la Timone, CEMEREM, Marseille, France
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Annie Verschueren
aFrom the Centre de Résonance Magnétique Biologique et Médicale (P.T., M.M.E.M., B.T., W.Z., A.V., M.G., A.-M.G., J.-P.S.), Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France
eReferral Centre for Neuromuscular Diseases and ALS (A.V., S.A., A.-M.G.), Assistance Publique-Marseille Hospitals, Hôpital de la Timone, Marseille, France
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Shahram Attarian
eReferral Centre for Neuromuscular Diseases and ALS (A.V., S.A., A.-M.G.), Assistance Publique-Marseille Hospitals, Hôpital de la Timone, Marseille, France
fInstitut National de la Santé et de la Recherche Médicale (S.A.,), Marseille Medical Genetics Center, Aix-Marseille University, Marseille, France
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Maxime Guye
aFrom the Centre de Résonance Magnétique Biologique et Médicale (P.T., M.M.E.M., B.T., W.Z., A.V., M.G., A.-M.G., J.-P.S.), Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France
bAssistance Publique-Marseille Hospitals (P.T., M.M.E.M., B.T., W.Z., M.G., J.-P.S.), Hôpital de la Timone, CEMEREM, Marseille, France
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José Boucraut
dImmunology Laboratory (A.B., J.B.), Assistance Publique-Marseille Hospitals, Conception Hospital, Marseille, France
gInstitut National de la Santé et de la Recherche Médicale (J.B.) Institut de Neurosciences des Systèmes Aix-Marseille University, Marseille, France
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Aude-Marie Grapperon
aFrom the Centre de Résonance Magnétique Biologique et Médicale (P.T., M.M.E.M., B.T., W.Z., A.V., M.G., A.-M.G., J.-P.S.), Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France
eReferral Centre for Neuromuscular Diseases and ALS (A.V., S.A., A.-M.G.), Assistance Publique-Marseille Hospitals, Hôpital de la Timone, Marseille, France
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Jan-Patrick Stellmann
aFrom the Centre de Résonance Magnétique Biologique et Médicale (P.T., M.M.E.M., B.T., W.Z., A.V., M.G., A.-M.G., J.-P.S.), Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France
bAssistance Publique-Marseille Hospitals (P.T., M.M.E.M., B.T., W.Z., M.G., J.-P.S.), Hôpital de la Timone, CEMEREM, Marseille, France
cDepartment of Neuroradiology (A.M., B.T., J.-P.S.), Assistance Publique-Marseille Hospitals, Hôpital de la Timone, Marseille, France
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Article Information

DOI 
https://doi.org/10.3174/ajnr.A8154
PubMed 
38548305

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received March 27, 2023
  • Accepted after revision November 8, 2023
  • Published online March 28, 2024.

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  • You are currently viewing a Latest version of this article (March 28, 2024 - 08:17).
  • View the most recent version of this article
Copyright & Usage 
© 2024 by American Journal of Neuroradiology

Author Information

  1. Penelope Tilsleya,b,
  2. Antoine Moutiezc,
  3. Alexandre Brodovitchd,
  4. Mohamed Mounir El Mendilia,b,
  5. Benoit Testuda,b,c,
  6. Wafaa Zaaraouia,b,
  7. Annie Verschuerena,e,
  8. Shahram Attariane,f,
  9. Maxime Guyea,b,
  10. José Boucrautd,g,
  11. Aude-Marie Grapperona,e and
  12. Jan-Patrick Stellmanna,b,c
  1. aFrom the Centre de Résonance Magnétique Biologique et Médicale (P.T., M.M.E.M., B.T., W.Z., A.V., M.G., A.-M.G., J.-P.S.), Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France
  2. bAssistance Publique-Marseille Hospitals (P.T., M.M.E.M., B.T., W.Z., M.G., J.-P.S.), Hôpital de la Timone, CEMEREM, Marseille, France
  3. cDepartment of Neuroradiology (A.M., B.T., J.-P.S.), Assistance Publique-Marseille Hospitals, Hôpital de la Timone, Marseille, France
  4. dImmunology Laboratory (A.B., J.B.), Assistance Publique-Marseille Hospitals, Conception Hospital, Marseille, France
  5. eReferral Centre for Neuromuscular Diseases and ALS (A.V., S.A., A.-M.G.), Assistance Publique-Marseille Hospitals, Hôpital de la Timone, Marseille, France
  6. fInstitut National de la Santé et de la Recherche Médicale (S.A.,), Marseille Medical Genetics Center, Aix-Marseille University, Marseille, France
  7. gInstitut National de la Santé et de la Recherche Médicale (J.B.) Institut de Neurosciences des Systèmes Aix-Marseille University, Marseille, France
  1. Please address correspondence to Penelope Tilsley, PhD, CRMBM-CEMEREM, Center Hospitalier Regional de Marseille, APHM, 264 rue Sainte-Pierre, Marseille, 13385, France; e-mail: tilsley.penelope{at}gmail.com
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Funding

  • Horizon 2020 Framework Programme

    945539
  • FRC (Fédération pour la Recherche sur le Cerveau)

  • Association pour la Recherche sur la Sclérose Latérale

  • APHM AORC Junior 2014 program

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Penelope Tilsley, Antoine Moutiez, Alexandre Brodovitch, Mohamed Mounir El Mendili, Benoit Testud, Wafaa Zaaraoui, Annie Verschueren, Shahram Attarian, Maxime Guye, José Boucraut, Aude-Marie Grapperon, Jan-Patrick Stellmann
Neurofilament Light Chain Levels Interact with Neurodegenerative Patterns and Motor Neuron Dysfunction in Amyotrophic Lateral Sclerosis
American Journal of Neuroradiology Mar 2024, DOI: 10.3174/ajnr.A8154

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Neurofilament Light Chain Levels Interact with Neurodegenerative Patterns and Motor Neuron Dysfunction in Amyotrophic Lateral Sclerosis
Penelope Tilsley, Antoine Moutiez, Alexandre Brodovitch, Mohamed Mounir El Mendili, Benoit Testud, Wafaa Zaaraoui, Annie Verschueren, Shahram Attarian, Maxime Guye, José Boucraut, Aude-Marie Grapperon, Jan-Patrick Stellmann
American Journal of Neuroradiology Mar 2024, DOI: 10.3174/ajnr.A8154
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