Femoral Access-Site Complications with Tenecteplase versus Alteplase before Mechanical Thrombectomy for Large-Vessel-Occlusion Stroke

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FIGURE.
Patient flowchart. “Pts” indicates patients.

Table 1:

Femoral access-site complications

	TNK (n = 46)	TPA (n = 93)	P Value
Baseline
Age (IQR)	73 (64–79)	74 (62–83)	.62
Female	24 (52.2%)	44 (64.7%)	.59
Risk factors
Arterial hypertension^{^a}	39 (84.8%)	64 (69.6%)	.05
Type 2 diabetes^{^a}	11 (23.9%)	19 (20.7%)	.66
Dyslipidemia^{^a}	29 (63.0%)	49 (53.3%)	.27
Coronary artery disease^{^a}	10 (21.7%)	22 (23.9%)	.78
Atrial fibrillation^{^a}	13 (28.3%)	38 (41.3%)	.14
Chronic kidney disease^{^a}	8 (17.4%)	13 (14.1%)	.62
Ischemic stroke^{^b}	9 (19.6%)	22 (23.7%)	.59
Smoking (ever)^{^c}	26 (56.5%)	40 (44.0%)	.16
Primary presentation at CSC	26 (56.5%)	29 (31.2%)	.004
LKW to IV thrombolytic (IQR)	109 (90–149)	119 (91–172)	.28
IV thrombolytic to groin puncture (IQR)	74 (48–109)	91 (66–136)	.07
Antithrombotics	23 (50.0%)	45 (48.4%)	.86
Aspirin	18 (39.1%)	31 (33.3%)
Aspirin and Clopidogrel	3 (6.5%)	5 (5.4%)
Clopidogrel	0 (0.0%)	1 (1.1%)
Coumadin	1 (2.2%)	4 (4.3%)
Aspirin and Coumadin	0 (0.0%)	1 (1.1%)
Clopidogrel and Coumadin	1 (2.2%)	3 (3.2%)
Periprocedural
8F femoral sheath	46 (100.0%)	93 (100.0%)	NA
Sonographically guided access	0 (0.0%)	0 (0.0%)	NA
Angio-Seal closure device	46 (100.0%)	93 (100.0%)	NA
Coagulation labs < 12h
INR (IQR)^{^d}	1.07 (0.99–1.12)	1.18 (1.09–1.31)	.001
PT (IQR)^{^e}	14 (13–15)	15 (14–16)	.001
aPTT (IQR)^{^f}	30 (28–31)	29 (28–32)	1.00

Note:—IQR indicates interquartile range; LKW, last known well; aPTT, activated partial thromboplastin times; NA, not available.
↵a Data missing in 1 TPA.
↵b Data missing in 3 TPAs.
↵c Data missing in 5 TPAs.
↵d Data available in 22 and 45 patients with TNK and TPA, respectively.
↵e Data available in 22 and 46 patients with TNK and TPA, respectively.
↵f Data available in 18 and 29 patients with TNK and TPA, respectively.

Table 2:

Femoral access-site complications

Access-Site Complications	TNK (n = 46)	TPA (n = 93)	P Value
Minor
Groin hematoma	1 (2.2%)	4 (4.3%)	1.00
Delayed oozing	3 (6.5%)	2 (2.2%)	.33
Pseudoaneurysm (conservative)	0 (0.0%)	1 (1.1%)	1.00
Major
Arterial occlusion	1 (2.2%)	1 (1.1%)