Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging
Open Access

Imaging Characteristics of CNS Neuroblastoma-FOXR2: A Retrospective and Multi-Institutional Description of 25 Cases

A. Tietze, K. Mankad, M.H. Lequin, L. Ivarsson, D. Mirsky, A. Jaju, M. Kool, K.V. Hoff, B. Bison and U. Löbel
American Journal of Neuroradiology September 2022, DOI: https://doi.org/10.3174/ajnr.A7644
A. Tietze
aFrom the Institute of Neuroradiology (A.T.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Tietze
K. Mankad
cDepartment of Radiology (K.M., U.L.), Great Ormond Street Hospital, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K. Mankad
M.H. Lequin
dDepartment of Radiology (M.H.L.), University Medical Center Utrecht, Utrecht, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.H. Lequin
L. Ivarsson
eDepartment of Pediatric Radiology (L.I.), Queen Silvias Children’s Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for L. Ivarsson
D. Mirsky
fDepartment of Pediatric Radiology and Imaging (D.M.), Children’s Hospital Colorado, Denver, Colorado
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Mirsky
A. Jaju
gDepartment of Medical Imaging (A.J.), Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Jaju
M. Kool
hHopp Children’s Cancer Center (M.K.), Heidelberg, Germany
iDivision of Pediatric Neurooncology (M.K.), German Cancer Research Center and German Cancer Consortium, Heidelberg, Germany
jPrincess Máxima Center for Pediatric Oncology (M.K.), Utrecht, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Kool
K.V. Hoff
bDepartment of Pediatric Oncology and Hematology (K.V.H.), Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K.V. Hoff
B. Bison
kDepartment of Neuroradiology (B.B.), University Hospital Augsburg, Ausburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B. Bison
U. Löbel
cDepartment of Radiology (K.M., U.L.), Great Ormond Street Hospital, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for U. Löbel
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Louis DN,
    2. Perry A,
    3. Wesseling P, et al
    . The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol 2021;23:1231–51 doi:10.1093/neuonc/noab106 pmid:34185076
    CrossRefPubMed
  2. 2.↵
    1. Louis DN,
    2. Ohgaki H,
    3. Wiestler OD, et al
    . The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97–109 doi:10.1007/s00401-007-0243-4 pmid:17618441
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Sturm D,
    2. Orr BA,
    3. Toprak UH, et al
    . New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell 2016;164:1060–72 doi:10.1016/j.cell.2016.01.015 pmid:26919435
    CrossRefPubMed
  4. 4.↵
    1. von Hoff K,
    2. Haberler C,
    3. Schmitt-Hoffner F, et al
    . Therapeutic implications of improved molecular diagnostics for rare CNS embryonal tumor entities: results of an international, retrospective study. Neuro Oncol 2021;23:1597–611 doi:10.1093/neuonc/noab136 pmid:34077956
    CrossRefPubMed
  5. 5.↵
    1. Korshunov A,
    2. Okonechnikov K,
    3. Schmitt-Hoffner F, et al
    . Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation. Acta Neuropathol Commun 2021;9:20 doi:10.1186/s40478-021-01118-5 pmid:33536079
    CrossRefPubMed
  6. 6.↵
    1. Holsten T,
    2. Lubieniecki F,
    3. Spohn M, et al
    . Detailed clinical and histopathological description of 8 cases of molecularly defined CNS neuroblastomas. J Neuropathol Exp Neurol 2021;80:52–59 doi:10.1093/jnen/nlaa128 pmid:33270865
    CrossRefPubMed
  7. 7.↵
    1. Furuta T,
    2. Moritsubo M,
    3. Muta H, et al
    . Central nervous system neuroblastic tumor with FOXR2 activation presenting both neuronal and glial differentiation: a case report. Brain Tumor Pathol 2020;37:100–104 doi:10.1007/s10014-020-00370-2 pmid:32535663
    CrossRefPubMed
  8. 8.↵
    1. Capper D,
    2. Jones DTW,
    3. Sill M, et al
    . DNA methylation-based classification of central nervous system tumours. Nature 2018;555:469–74 doi:10.1038/nature26000 pmid:29539639
    CrossRefPubMed
  9. 9.↵
    1. Stock A,
    2. Mynarek M,
    3. Pietsch T, et al
    . Characteristics of wingless pathway subgroup medulloblastomas: results from the German Imaging HIT/SIOP-Trial Cohort. AJNR Am J Neuroradiol 2019;40:1811–17 doi:10.3174/ajnr.A6286 pmid:31649159
    Abstract/FREE Full Text
  10. 10.↵
    1. Ferris SP,
    2. Velazquez Vega J,
    3. Aboian M, et al
    . High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication: a comprehensive clinical, radiographic, pathologic, and genomic analysis. Brain Pathol 2020;30:46–62 doi:10.1111/bpa.12747 pmid:31104347
    CrossRefPubMed
  11. 11.↵
    1. De Lima L,
    2. Sürme MB,
    3. Gessi M, et al
    . Central nervous system high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR): case-based reviews. Childs Nerv Syst 2020;36:1589–99 doi:10.1007/s00381-020-04692-6 pmid:32542405
    CrossRefPubMed
  12. 12.
    1. Hu W,
    2. Wang J,
    3. Yuan L, et al
    . Case report: a unique case of pediatric central nervous system embryonal tumor harboring the CIC–LEUTX fusion, germline NBN variant and somatic TSC2 mutation: expanding the spectrum of CIC-rearranged neoplasia. Front Oncol 2020;10:598970 doi:10.3389/fonc.2020.598970 pmid:33344249
    CrossRefPubMed
  13. 13.↵
    1. Cardoen L,
    2. Tauziède-Espariat A,
    3. Dangouloff-Ros V, et al
    . Imaging features with histopathologic correlation of CNS high-grade neuroepithelial tumors with a BCOR internal tandem duplication. AJNR Am J Neuroradiol 2022;43:151–56 doi:10.3174/ajnr.A7367 pmid:34887247
    Abstract/FREE Full Text
  14. 14.↵
    1. Jin B,
    2. Feng XY
    . MRI features of atypical teratoid/rhabdoid tumors in children. Pediatr Radiology 2013;43:1001–08 doi:10.1007/s00247-013-2646-9 pmid:23467756
    CrossRefPubMed
  15. 15.
    1. Meyers SP,
    2. Khademian ZP,
    3. Biegel JA, et al
    . Primary intracranial atypical teratoid/rhabdoid tumors of infancy and childhood: MRI features and patient outcomes. AJNR Am J Neuroradiol 2006;27:962–71 pmid:16687525
    PubMedWeb of Science
  16. 16.
    1. Yamasaki K,
    2. Kiyotani C,
    3. Terashima K, et al
    . Clinical characteristics, treatment, and survival outcome in pediatric patients with atypical teratoid/rhabdoid tumors: a retrospective study by the Japan Children’s Cancer Group. J Neurosurg Pediatr 2019;15:1–10 doi:10.3171/2019.9.PEDS19367 pmid:31731266
    CrossRefPubMed
  17. 17.
    1. Mangalore S,
    2. Aryan S,
    3. Prasad C, et al
    . Imaging characteristics of supratentorial ependymomas: study on a large single institutional cohort with histopathological correlation. Asian J Neurosurg 2015;10:276–81 doi:10.4103/1793-5482.162702 pmid:26425155
    CrossRefPubMed
  18. 18.
    1. Wang Q,
    2. Cheng J,
    3. Li J, et al
    . The survival and prognostic factors of supratentorial cortical ependymomas: a retrospective cohort study and literature-based analysis. Front Oncol 2020;10:1585 doi:10.3389/fonc.2020.01585 pmid:32974195
    CrossRefPubMed
  19. 19.↵
    1. Warmuth-Metz M,
    2. Bison B,
    3. Gerber NU, et al
    . Bone involvement in atypical teratoid/rhabdoid tumors of the CNS. AJNR Am J Neuroradiol 2013;34:2039–42 doi:10.3174/ajnr.A3554 pmid:23681355
    Abstract/FREE Full Text
  20. 20.↵
    WHO Classification of Tumours Editorial Board. Central Nervous System Tumours: Who Classification of Tumours. 5th ed. International Agency for Research on Cancer; December 2021
  21. 21.↵
    1. Frühwald MC,
    2. Hasselblatt M,
    3. Nemes K, et al
    . Age and DNA methylation subgroup as potential independent risk factors for treatment stratification in children with atypical teratoid/rhabdoid tumors. Neuro Oncol 2020;22:1006–17 doi:10.1093/neuonc/noz244 pmid:31883020
    CrossRefPubMed
  22. 22.↵
    1. Khan S,
    2. Solano-Paez P,
    3. Suwal T, et al
    . Clinical phenotypes and prognostic features of embryonal tumours with multi-layered rosettes: a Rare Brain Tumor Registry study. Lancet Child Adolesc Health 2021;5:800–13 doi:10.1016/S2352-4642(21)00245-5 pmid:34599879
    CrossRefPubMed
  23. 23.↵
    1. Pajtler KW,
    2. Witt H,
    3. Sill M, et al
    . Molecular classification of ependymal tumors across all CNS compartments, histopathological grades, and age groups. Cancer Cell 2015;27:728–43 doi:10.1016/j.ccell.2015.04.002 pmid:25965575
    CrossRefPubMed
  24. 24.↵
    1. Andreiuolo F,
    2. Varlet P,
    3. Tauziède-Espariat A, et al
    . Childhood supratentorial ependymomas with YAP1-MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features. Brain Pathol 2019;29:205–16 doi:10.1111/bpa.12659 pmid:30246434
    CrossRefPubMed
  25. 25.↵
    1. Maier SE,
    2. Sun Y,
    3. Mulkern RV
    . Diffusion imaging of brain tumors. NMR Biomed 2010;23:849–64 doi:10.1002/nbm.1544 pmid:20886568
    CrossRefPubMedWeb of Science
  26. 26.↵
    VASARI Research Project. March 30, 2020. https://wiki.cancerimagingarchive.net/display/Public/VASARI+Research+Project. Accessed May 29, 2022
PreviousNext
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Imaging Characteristics of CNS Neuroblastoma-FOXR2: A Retrospective and Multi-Institutional Description of 25 Cases
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
A. Tietze, K. Mankad, M.H. Lequin, L. Ivarsson, D. Mirsky, A. Jaju, M. Kool, K.V. Hoff, B. Bison, U. Löbel
Imaging Characteristics of CNS Neuroblastoma-FOXR2: A Retrospective and Multi-Institutional Description of 25 Cases
American Journal of Neuroradiology Sep 2022, DOI: 10.3174/ajnr.A7644

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Imaging Characteristics of CNS Neuroblastoma-FOXR2: A Retrospective and Multi-Institutional Description of 25 Cases
A. Tietze, K. Mankad, M.H. Lequin, L. Ivarsson, D. Mirsky, A. Jaju, M. Kool, K.V. Hoff, B. Bison, U. Löbel
American Journal of Neuroradiology Sep 2022, DOI: 10.3174/ajnr.A7644
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis
  • Newly Recognized CNS Tumors in the 2021 World Health Organization Classification: Imaging Overview with Histopathologic and Genetic Correlation
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Frontal Paraventricular Cysts
  • Sodium MRI in Pediatric Brain Tumors
  • FRACTURE MR in Congenital Vertebral Anomalies
Show more Pediatric Neuroimaging

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire