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Research ArticleHead and Neck Imaging

Detection of Optic Neuritis on Routine Brain MRI without and with the Assistance of an Image Postprocessing Algorithm

A. Schroeder, G. Van Stavern, H.L.P. Orlowski, L. Stunkel, M.S. Parsons, L. Rhea and A. Sharma
American Journal of Neuroradiology March 2021, DOI: https://doi.org/10.3174/ajnr.A7068
A. Schroeder
aFrom the Washington University in Saint Louis School of Medicine, (A. Schroeder)
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G. Van Stavern
bDepartments of Ophthalmology and Visual Sciences (G.V.S., L.S.)
cNeurology (G.V.S., L.S.)
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H.L.P. Orlowski
dMallinckrodt Institute of Radiology (H.L.P.O., M.S.P., A. S.)
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L. Stunkel
bDepartments of Ophthalmology and Visual Sciences (G.V.S., L.S.)
cNeurology (G.V.S., L.S.)
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M.S. Parsons
dMallinckrodt Institute of Radiology (H.L.P.O., M.S.P., A. S.)
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L. Rhea
eDepartment of Biostatistics (L.R.), Washington University in Saint Louis School of Medicine, St. Louis, Missouri
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A. Sharma
dMallinckrodt Institute of Radiology (H.L.P.O., M.S.P., A. S.)
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References

  1. 1.↵
    The clinical profile of optic neuritis: experience of the Optic Neuritis Treatment Trial—Optic Neuritis Study Group. Arch Ophthalmol 1991;109:1673–78 pmid:1841573
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Rizzo JF 3rd.,
    2. Lessell S
    . Optic neuritis and ischemic optic neuropathy: overlapping clinical profiles. Arch Ophthalmol 1991;109:1668–72 doi:10.1001/archopht.1991.01080120052024 pmid:1841572
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Bee YS,
    2. Lin MC,
    3. Wang CC, et al
    . Optic neuritis: clinical analysis of 27 cases. Kaohsiung J Med Sci 2003;19:105–12 doi:10.1016/S1607-551X(09)70457-7 pmid:12751870
    CrossRefPubMed
  4. 4.↵
    1. Balcer LJ
    . Clinical practice: optic neuritis. N Engl J Med 2006;354:1273–80 doi:10.1056/NEJMcp053247 pmid:16554529
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Toosy AT,
    2. Mason DF,
    3. Miller DH
    . Optic neuritis. Lancet Neurol 2014;13:83–99 doi:10.1016/S1474-4422(13)70259-X pmid:24331795
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Hoorbakht H,
    2. Bagherkashi F
    . Optic neuritis, its differential diagnosis and management. Open Ophthalmol J 2012;6:65–72 doi:10.2174/1874364101206010065 pmid:22888383
    CrossRefPubMed
  7. 7.↵
    1. Keltner JL,
    2. Johnson CA,
    3. Spurr JO, et al
    . Baseline visual field profile of optic neuritis: the experience of the optic neuritis treatment trial–Optic Neuritis Study Group. Arch Ophthalmol 1993;111:231–34 doi:10.1001/archopht.1993.01090020085029 pmid:8431161
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Fang JP,
    2. Donahue SP,
    3. Lin RH
    . Global visual field involvement in acute unilateral optic neuritis. Am J Ophthalmol 1999;128:554–65 doi:10.1016/S0002-9394(99)00298-6 pmid:10577522
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Wilhelm H,
    2. Schabet M
    . The diagnosis and treatment of optic neuritis. Dtsch Arztebl Int 2015;112:616–25; quiz 626 doi:10.3238/arztebl.2015.0616 pmid:26396053
    CrossRefPubMed
  10. 10.↵
    1. Rizzo JF 3rd.,
    2. Andreoli CM,
    3. Rabinov JD
    . Use of magnetic resonance imaging to differentiate optic neuritis and nonarteritic anterior ischemic optic neuropathy. Ophthalmology 2002;109:1679–84 doi:10.1016/S0161-6420(02)01148-X pmid:12208717
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Bursztyn L,
    2. De Lott LB,
    3. Petrou M, et al
    . Sensitivity of orbital magnetic resonance imaging in acute demyelinating optic neuritis. Can J Ophthalmol 2019;54:242–46 doi:10.1016/j.jcjo.2018.05.013 pmid:30975349
    CrossRefPubMed
  12. 12.↵
    1. Kupersmith MJ,
    2. Alban T,
    3. Zeiffer B, et al
    . Contrast-enhanced MRI in acute optic neuritis: relationship to visual performance. Brain 2002;125:812–22 doi:10.1093/brain/awf087 pmid:11912114
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Hickman SJ,
    2. Toosy AT,
    3. Miszkiel KA, et al
    . Visual recovery following acute optic neuritis: a clinical, electrophysiological and magnetic resonance imaging study. J Neurol 2004;251:996–1005 doi:10.1007/s00415-004-0477-1 pmid:15316805
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Stunkel L,
    2. Kung NH,
    3. Wilson B, et al
    . Incidence and causes of overdiagnosis of optic neuritis. JAMA Ophthalmol 2018;136:76–81 doi:10.1001/jamaophthalmol.2017.5470 pmid:29222573
    CrossRefPubMed
  15. 15.↵
    1. Stunkel L,
    2. Sharma A,
    3. Parsons MS, et al
    . Evaluating the utility of a postprocessing algorithm for MRI evaluation of optic neuritis. AJNR Am J Neuroradiol 2019;40:1043–48 doi:10.3174/ajnr.A6057 pmid:31048299
    Abstract/FREE Full Text
  16. 16.↵
    1. McKinney AM,
    2. Lohman BD,
    3. Sarikaya B, et al
    . Accuracy of routine fat-suppressed FLAIR and diffusion-weighted images in detecting clinically evident acute optic neuritis. Acta Radiol 2013;54:455–61 doi:10.1177/0284185112471797 pmid:23386735
    CrossRefPubMed
  17. 17.↵
    1. Guy J,
    2. Mao J,
    3. Bidgood WD Jr., et al
    . Enhancement and demyelination of the intraorbital optic nerve: fat suppression magnetic resonance imaging. Ophthalmology 1992;99:713–19 doi:10.1016/S0161-6420(92)31892-5 pmid:1594216
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Thompson AJ,
    2. Banwell BL,
    3. Barkhof F, et al
    . Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol 2018;17:162–73 doi:10.1016/S1474-4422(17)30470-2 pmid:29275977
    CrossRefPubMed
  19. 19.↵
    1. Sartoretti T,
    2. Sartoretti E,
    3. Rauch S, et al
    . How common is signal-intensity increase in optic nerve segments on 3D double inversion recovery sequences in visually asymptomatic patients with multiple sclerosis? AJNR Am J Neuroradiol 2017;38:1748–53 doi:10.3174/ajnr.A5262 pmid:28663263
    Abstract/FREE Full Text
  20. 20.↵
    1. Giorgio A,
    2. De Stefano N
    . Effective utilization of MRI in the diagnosis and management of multiple sclerosis. Neurol Clin 2018;36:27–34 doi:10.1016/j.ncl.2017.08.013 pmid:29157402
    CrossRefPubMed
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Cite this article
A. Schroeder, G. Van Stavern, H.L.P. Orlowski, L. Stunkel, M.S. Parsons, L. Rhea, A. Sharma
Detection of Optic Neuritis on Routine Brain MRI without and with the Assistance of an Image Postprocessing Algorithm
American Journal of Neuroradiology Mar 2021, DOI: 10.3174/ajnr.A7068

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Detection of Optic Neuritis on Routine Brain MRI without and with the Assistance of an Image Postprocessing Algorithm
A. Schroeder, G. Van Stavern, H.L.P. Orlowski, L. Stunkel, M.S. Parsons, L. Rhea, A. Sharma
American Journal of Neuroradiology Mar 2021, DOI: 10.3174/ajnr.A7068
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