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Review ArticleReview Articles
Open Access

Skull Base Osteomyelitis: A Comprehensive Imaging Review

P.R. Chapman, G. Choudhary and A. Singhal
American Journal of Neuroradiology January 2021, DOI: https://doi.org/10.3174/ajnr.A7015
P.R. Chapman
aFrom the Section of Neuroradiology, Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama
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G. Choudhary
aFrom the Section of Neuroradiology, Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama
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A. Singhal
aFrom the Section of Neuroradiology, Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama
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References

  1. 1.↵
    1. Carfrae MJ,
    2. Kesser BW
    . Malignant otitis externa. Otolaryngol Clin North Am 2008;41:537–49 doi:10.1016/j.otc.2008.01.004 pmid:18435997
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Johnson AK,
    2. Batra PS
    . Central skull base osteomyelitis: an emerging clinical entity. Laryngoscope 2014;124:1083–87 doi:10.1002/lary.24440 pmid:24115113
    CrossRefPubMed
  3. 3.↵
    1. Chang PC,
    2. Fischbein NJ,
    3. Holliday RA
    . Central skull base osteomyelitis in patients without otitis externa: imaging findings. AJNR Am J Neuroradiol 2003;24:1310–16 pmid:12917118
    Abstract/FREE Full Text
  4. 4.↵
    1. Borges A
    . Imaging of the central skull base. Neuroimaging Clin N Am 2009;19:669–96 doi:10.1016/j.nic.2009.11.001 pmid:19959012
    CrossRefPubMed
  5. 5.↵
    1. Clark MP,
    2. Pretorius PM,
    3. Byren I, et al
    . Central or atypical skull base osteomyelitis: diagnosis and treatment. Skull Base 2009;19:247–54 doi:10.1055/s-0028-1115325 pmid:20046592
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. van Kroonenburgh A,
    2. van der Meer WL,
    3. Bothof RJ, et al
    . Advanced imaging techniques in skull base osteomyelitis due to malignant otitis externa. Curr Radiol Rep 2018;6:3 doi:10.1007/s40134-018-0263-y pmid:29416952
    CrossRefPubMed
  7. 7.↵
    1. Bag AK,
    2. Chapman PR
    . Neuroimaging: intrinsic lesions of the central skull base region. Semin Ultrasound CT MR 2013;34:412–35 doi:10.1053/j.sult.2013.08.004 pmid:24216451
    CrossRefPubMed
  8. 8.↵
    1. Prasad SC,
    2. Prasad KC,
    3. Kumar A, et al
    . Osteomyelitis of the temporal bone: terminology, diagnosis, and management. J Neurol Surg B Skull Base 2014;75:324–31 doi:10.1055/s-0034-1372468 pmid:25302143
    CrossRefPubMed
  9. 9.↵
    1. Chen JC,
    2. Yeh CF,
    3. Shiao AS, et al
    . Temporal bone osteomyelitis: the relationship with malignant otitis externa, the diagnostic dilemma, and changing trends. ScientificWorldJournal 2014;2014:591714 doi:10.1155/2014/591714 pmid:24963511
    CrossRefPubMed
  10. 10.↵
    1. Ducic Y
    . Skull base osteomyelitis. South Med J 2006;99:1051 doi:10.1097/01.smj.0000223663.36224.14 pmid:17100019
    CrossRefPubMed
  11. 11.↵
    1. Adams A,
    2. Offiah C
    . Central skull base osteomyelitis as a complication of necrotizing otitis externa: imaging findings, complications, and challenges of diagnosis. Clin Radiol 2012;67:e7–16 doi:10.1016/j.crad.2012.02.004 pmid:22483946
    CrossRefPubMed
  12. 12.↵
    1. Holder CD,
    2. Gurucharri M,
    3. Bartels LJ, et al
    . Malignant external otitis with optic neuritis. Laryngoscope 1986;96:1021–23 pmid:3747688
    PubMedWeb of Science
  13. 13.↵
    1. Huang KL,
    2. Lu CS
    . Skull base osteomyelitis presenting as Villaret’s syndrome. Acta Neurol Taiwan 2006;15:255–58 pmid:7214089
    PubMed
  14. 14.↵
    1. Rubin Grandis J,
    2. Branstetter BF,
    3. Yu VL
    . The changing face of malignant (necrotising) external otitis: clinical, radiological, and anatomic correlations. Lancet Infect Dis 2004;4:34–39 doi:10.1016/S1473-3099(03)00858-2 pmid:14720566
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Chan LL,
    2. Singh S,
    3. Jones D, et al
    . Imaging of mucormycosis skull base osteomyelitis. AJNR Am J Neuroradiol 2000;21:828–31 pmid:10815656
    Abstract/FREE Full Text
  16. 16.↵
    1. Chandler JR,
    2. Grobman L,
    3. Quencer R, et al
    . Osteomyelitis of the base of the skull. Laryngoscope 1986;96:245–51 doi:10.1288/00005537-198603000-00003 pmid:3485233
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Ozgen B,
    2. Oguz KK,
    3. Cila A
    . Diffusion MR imaging features of skull base osteomyelitis compared with skull base malignancy. AJNR Am J Neuroradiol 2011;32:179–84 doi:10.3174/ajnr.A2237 pmid:20947640
    Abstract/FREE Full Text
  18. 18.↵
    1. Ridder GJ,
    2. Breunig C,
    3. Kaminsky J, et al
    . Central skull base osteomyelitis: new insights and implications for diagnosis and treatment. Eur Arch Otorhinolaryngol 2015;272:1269–76 doi:10.1007/s00405-014-3390-y pmid:25381580
    CrossRefPubMed
  19. 19.↵
    1. Singh A,
    2. Al Khabori M,
    3. Hyder MJ
    . Skull base osteomyelitis: diagnostic and therapeutic challenges in atypical presentation. Otolaryngol Head Neck Surg 2005;133:121–25 doi:10.1016/j.otohns.2005.03.024 pmid:16025065
    CrossRefPubMed
  20. 20.↵
    1. Kwon BJ,
    2. Han MH,
    3. Oh SH, et al
    . MRI findings and spreading patterns of necrotizing external otitis: is a poor outcome predictable? Clin Radiol 2006;61:495–504 doi:10.1016/j.crad.2006.01.010 pmid:16713420
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Alleyne CH, Jr.,
    2. Vishteh AG,
    3. Spetzler RF, et al
    . Long-term survival of a patient with invasive cranial base rhinocerebral mucormycosis treated with combined endovascular, surgical, and medical therapies: case report. Neurosurgery 1999;45:1461–63; discussion 1463–64 doi:10.1097/00006123-199912000-00037 pmid:10598714
    CrossRefPubMed
  22. 22.↵
    1. Djalilian HR,
    2. Shamloo B,
    3. Thakkar KH, et al
    . Treatment of culture-negative skull base osteomyelitis. Otol Neurotol 2006;27:250–55 doi:10.1097/01.mao.0000181185.26410.80 pmid:16436997
    CrossRefPubMed
  23. 23.↵
    1. See A,
    2. Tan TY,
    3. Gan EC
    . Atypical culture-negative skull base osteomyelitis masquerading as advanced nasopharyngeal carcinoma. Am J Otolaryngol 2016;37:236–39 doi:10.1016/j.amjoto.2016.01.003 pmid:27178515
    CrossRefPubMed
  24. 24.↵
    1. Loh S,
    2. Loh WS
    . Malignant otitis externa: an Asian perspective on treatment outcomes and prognostic factors. Otolaryngol Head Neck Surg 2013;148:991–96 doi:10.1177/0194599813482107 pmid:23558287
    CrossRefPubMed
  25. 25.↵
    1. Spielmann PM,
    2. Yu R,
    3. Neeff M
    . Skull base osteomyelitis: current microbiology and management. J Laryngol Otol 2013;127(Suppl 1):S8–12 doi:10.1017/S0022215112002356 pmid:23089314
    CrossRefPubMed
  26. 26.↵
    1. Mahdyoun P,
    2. Pulcini C,
    3. Gahide I, et al
    . Necrotizing otitis externa: a systematic review. Otol Neurotol 2013;34:620–29 doi:10.1097/MAO.0b013e3182804aee pmid:23598690
    CrossRefPubMed
  27. 27.↵
    1. Le Clerc N,
    2. Verillaud B,
    3. Duet M, et al
    . Skull base osteomyelitis: incidence of resistance, morbidity, and treatment strategy. Laryngoscope 2014;124:2013–16 doi:10.1002/lary.24726 pmid:24752664
    CrossRefPubMed
  28. 28.↵
    1. Sokołowski J,
    2. Lachowska M,
    3. Karchier E, et al
    . Skull base osteomyelitis: factors implicating clinical outcome. Acta Neurol Belg 2019;119:431–37 doi:10.1007/s13760-019-01110-w pmid:30840222
    CrossRefPubMed
  29. 29.↵
    1. Jain N,
    2. Jasper A,
    3. Vanjare HA, et al
    . The role of imaging in skull base osteomyelitis: reviewed. Clin Imaging 2020;67:62–67 doi:10.1016/j.clinimag.2020.05.019 pmid:32526659
    CrossRefPubMed
  30. 30.↵
    1. Rothholtz VS,
    2. Lee AD,
    3. Shamloo B, et al
    . Skull base osteomyelitis: the effect of comorbid disease on hospitalization. Laryngoscope 2008;118:1917–24 doi:10.1097/MLG.0b013e31817fae0d pmid:18641525
    CrossRefPubMed
  31. 31.↵
    1. Rubin J,
    2. Curtin HD,
    3. Yu VL, et al
    . Malignant external otitis: utility of CT in diagnosis and follow-up. Radiology 1990;174:391–94 doi:10.1148/radiology.174.2.2104989 pmid:2104989
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Mendelson DS,
    2. Som PM,
    3. Mendelson MH, et al
    . Malignant external otitis: the role of computed tomography and radionuclides in evaluation. Radiology 1983;149:745–49 doi:10.1148/radiology.149.3.6580674 pmid:6580674
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Balakrishnan R,
    2. Dalakoti P,
    3. Nayak DR, et al
    . Efficacy of HRCT imaging vs SPECT/CT scans in the staging of malignant external otitis. Otolaryngol Head Neck Surg 2019;161:336–42 doi:10.1177/0194599819838834 pmid:30987522
    CrossRefPubMed
  34. 34.↵
    1. Chakraborty D,
    2. Bhattacharya A,
    3. Gupta AK, et al
    . Skull base osteomyelitis in otitis externa: the utility of triphasic and single photon emission computed tomography/computed tomography bone scintigraphy. Indian J Nucl Med 2013;28:65–69 doi:10.4103/0972-3919.118222 pmid:24163508
    CrossRefPubMed
  35. 35.↵
    1. Strashun AM,
    2. Nejatheim M,
    3. Goldsmith SJ
    . Malignant external otitis: early scintigraphic detection. Radiology 1984;150:541–45 doi:10.1148/radiology.150.2.6228955 pmid:6228955
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Rozenblum-Beddok L,
    2. Verillaud B,
    3. Paycha F, et al
    . (99m)Tc-HMPAO-leukocyte scintigraphy for diagnosis and therapy monitoring of skull base osteomyelitis. Laryngoscope Investig Otolaryngol 2018;3:218–24 doi:10.1002/lio2.159 pmid:30062138
    CrossRefPubMed
  37. 37.↵
    1. Moss WJ,
    2. Finegersh A,
    3. Narayanan A, et al
    . Meta-analysis does not support routine traditional nuclear medicine studies for malignant otitis. Laryngoscope 2020;130:1812–16 doi:10.1002/lary.28411 pmid:31750969
    CrossRefPubMed
  38. 38.↵
    1. Kulkarni SC,
    2. Padma S,
    3. Shanmuga Sundaram P
    . In the evaluation of patients with skull base osteomyelitis, does 18F-FDG PET CT have a role? Nucl Med Commun 2020;41:550–59 doi:10.1097/MNM.0000000000001187 pmid:32282638
    CrossRefPubMed
  39. 39.↵
    1. Louarn N,
    2. Alias Q,
    3. Aupin L, et al
    . A rare presentation of skull-base osteomyelitis with neurovascular sheath extension following external otitis resolved by PET/MRI. Eur J Nucl Med Mol Imaging 2018;45:2025 doi:10.1007/s00259-018-4055-7 pmid:29799068
    CrossRefPubMed
  40. 40.↵
    1. Lesser FD,
    2. Derbyshire SG,
    3. Lewis-Jones H
    . Can computed tomography and magnetic resonance imaging differentiate between malignant pathology and osteomyelitis in the central skull base? J Laryngol Otol 2015;129:852–59 doi:10.1017/S0022215115001991 pmid:26314320
    CrossRefPubMed
  41. 41.↵
    1. Lee EJ,
    2. Jung SL,
    3. Kim BS, et al
    . MR imaging of orbital inflammatory pseudotumors with extraorbital extension. Korean J Radiol 2005;6:82–88 doi:10.3348/kjr.2005.6.2.82 pmid:15968146
    CrossRefPubMedWeb of Science
  42. 42.↵
    1. Yim CD,
    2. An HJ,
    3. Ahn SK, et al
    . IgG4-related disease presenting as otogenic skull base osteomyelitis. Auris Nasus Larynx 2020 Feb 25. [Epub ahead of print] doi:10.1016/j.anl.2020.02.006 pmid:32111411
    CrossRefPubMed
  43. 43.↵
    1. Ryu G,
    2. Cho HJ,
    3. Lee KE, et al
    . Clinical significance of IgG4 in sinonasal and skull base inflammatory pseudotumor. Eur Arch Otorhinolaryngol 2019;276:2465–73 doi:10.1007/s00405-019-05505-6 pmid:31203383
    CrossRefPubMed
  44. 44.↵
    1. Hsiao YC,
    2. Lee JC,
    3. Kang BH, et al
    . Idiopathic osteomyelitis at the base of the skull. South Med J 2006;99:1121–23 doi:10.1097/01.smj.0000224745.75981.52 pmid:17100033
    CrossRefPubMed
  45. 45.↵
    1. Chawdhary G,
    2. Pankhania M,
    3. Douglas S, et al
    . Current management of necrotising otitis externa in the UK: survey of 221 UK otolaryngologists. Acta Otolaryngol 2017;137:818–22 doi:10.1080/00016489.2017.1295468 pmid:28301961
    CrossRefPubMed
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P.R. Chapman, G. Choudhary, A. Singhal
Skull Base Osteomyelitis: A Comprehensive Imaging Review
American Journal of Neuroradiology Jan 2021, DOI: 10.3174/ajnr.A7015

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Skull Base Osteomyelitis: A Comprehensive Imaging Review
P.R. Chapman, G. Choudhary, A. Singhal
American Journal of Neuroradiology Jan 2021, DOI: 10.3174/ajnr.A7015
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