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Research ArticleNeurointervention

Applications of a Novel Microangioscope for Neuroendovascular Intervention

V.M. Srinivasan, T.T. Lazaro, A. Srivatsan, P. Cooper, M. Phillips, R. Garcia, S.R. Chen, J.N. Johnson, J.-K. Burkhardt, D.E. Collins and P. Kan
American Journal of Neuroradiology December 2020, DOI: https://doi.org/10.3174/ajnr.A6900
V.M. Srinivasan
aFrom the Department of Neurosurgery (V.M.S., T.T.L., A.S., R.G., J.N.J., J.-K.B., P.K.)
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  • ORCID record for V.M. Srinivasan
T.T. Lazaro
aFrom the Department of Neurosurgery (V.M.S., T.T.L., A.S., R.G., J.N.J., J.-K.B., P.K.)
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  • ORCID record for T.T. Lazaro
A. Srivatsan
aFrom the Department of Neurosurgery (V.M.S., T.T.L., A.S., R.G., J.N.J., J.-K.B., P.K.)
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P. Cooper
cVena Medical (P.C., M.P.), Kitchener, Ontario, Canada
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M. Phillips
cVena Medical (P.C., M.P.), Kitchener, Ontario, Canada
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R. Garcia
aFrom the Department of Neurosurgery (V.M.S., T.T.L., A.S., R.G., J.N.J., J.-K.B., P.K.)
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S.R. Chen
dDepartment of Interventional Radiology (S.R.C.), The MD Anderson Cancer Center, Houston, Texas
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J.N. Johnson
aFrom the Department of Neurosurgery (V.M.S., T.T.L., A.S., R.G., J.N.J., J.-K.B., P.K.)
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J.-K. Burkhardt
aFrom the Department of Neurosurgery (V.M.S., T.T.L., A.S., R.G., J.N.J., J.-K.B., P.K.)
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D.E. Collins
bCenter for Comparative Medicine (D.E.C.) Baylor College of Medicine, Houston, Texas
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P. Kan
aFrom the Department of Neurosurgery (V.M.S., T.T.L., A.S., R.G., J.N.J., J.-K.B., P.K.)
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  • FIG 1.
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    FIG 1.

    Clot identification and differentiation. A, Clot interface seen ex vivo with a red clot. A white clot is seen through the catheter (B) and in vivo in a porcine model (C). Red clots are seen clearly ex vivo (D), within the distal access catheter (E), and in vivo lodged in the porcine vessel (F).

  • FIG 2.
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    FIG 2.

    Visualization of a flow-diverting device by the microangioscope. A, The fine-woven mesh of the PED is seen. B, The interface between the PED and the distal vessel is seen (thin arrow), and the distal vessel is dark (thick arrow) and beyond the illumination of the microangioscope, giving depth perception. Thrombus formation is excluded, and good wall apposition is confirmed. C, After 1 month post-procedure, the device is partially endothelialized, with struts less visible (medium white arrow) and endothelium more prominent (medium black arrow).

  • FIG 3.
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    FIG 3.

    Visualization of mechanical thrombectomy. A, A clot is visualized by the microangioscope, and an aspiration catheter is positioned at the face of the clot. The interface between the artery and the clot is seen (thin arrow). B, Corresponding view on roadmap fluoroscopy shows the positioning of the aspiration catheter at the sharp cutoff point. C, A red thrombus is seen during removal by stent-retriever thrombectomy. D, The struts of the device can be clearly seen, as can the endothelium, with clear color differentiation (thick arrows).

Tables

  • Figures
  • Ratings of microangioscope image quality and interventional utility

    RatingsMD 1MD 2MD 3Mean
    Image-quality ratinga
     Video clip
      Diagnostic, cadaver carotid3454.0
      Diagnostic, clot identification2343.0
      Diagnostic, vessel wall injury2443.3
      Diagnostic, PED follow-up4554.7
      Diagnostic, PED initial3554.3
      Interventional, aspiration2433.0
      Interventional, stent retriever3433.3
      Interventional, coil embolization3554.3
      Interventional, WEB deployment2533.3
    Utility ratinga
     Interventional application
      Aspiration2433.0
      Stent retriever3433.3
      Coil embolization4554.7
      WEB deployment4554.7
    • Note:—MD indicates independent neurointerventionalist evaluator.

    • ↵a One worst; 5 best. Image quality rating scale described first, followed by device interventional utility rating scale:

      1) Poor, no diagnostic value; not useful at all for intervention.

      2) Limited diagnostic value; minimally useful, just of research value/interest.

      3) Average quality, of possible clinical utility; moderately useful, adds to procedure quality/safety.

      4) Good quality, minimal restrictions on visibility, probably adds benefit beyond angiography; significantly useful, should strongly consider for this indication.

      5) Excellent quality, adds benefit beyond angiography, could definitely use as an adjunct; extremely useful, would definitely use in most/all such procedures.

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Cite this article
V.M. Srinivasan, T.T. Lazaro, A. Srivatsan, P. Cooper, M. Phillips, R. Garcia, S.R. Chen, J.N. Johnson, J.-K. Burkhardt, D.E. Collins, P. Kan
Applications of a Novel Microangioscope for Neuroendovascular Intervention
American Journal of Neuroradiology Dec 2020, DOI: 10.3174/ajnr.A6900

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Applications of a Novel Microangioscope for Neuroendovascular Intervention
V.M. Srinivasan, T.T. Lazaro, A. Srivatsan, P. Cooper, M. Phillips, R. Garcia, S.R. Chen, J.N. Johnson, J.-K. Burkhardt, D.E. Collins, P. Kan
American Journal of Neuroradiology Dec 2020, DOI: 10.3174/ajnr.A6900
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