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Research ArticlePediatric Neuroimaging
Open Access

Introduction of Ultra-High-Field MR Imaging in Infants: Preparations and Feasibility

K.V. Annink, N.E. van der Aa, J. Dudink, T. Alderliesten, F. Groenendaal, M. Lequin, F.E. Jansen, K.S. Rhebergen, P. Luijten, J. Hendrikse, H.J.M. Hoogduin, E.R. Huijing, E. Versteeg, F. Visser, A.J.E. Raaijmakers, E.C. Wiegers, D.W.J. Klomp, J.P. Wijnen and M.J.N.L. Benders
American Journal of Neuroradiology July 2020, DOI: https://doi.org/10.3174/ajnr.A6702
K.V. Annink
aFrom the Departments of Neonatology (K.V.A., N.E.v.d.A., J.D., T.A., F.G., M.J.N.L.B.)
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N.E. van der Aa
aFrom the Departments of Neonatology (K.V.A., N.E.v.d.A., J.D., T.A., F.G., M.J.N.L.B.)
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J. Dudink
aFrom the Departments of Neonatology (K.V.A., N.E.v.d.A., J.D., T.A., F.G., M.J.N.L.B.)
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T. Alderliesten
aFrom the Departments of Neonatology (K.V.A., N.E.v.d.A., J.D., T.A., F.G., M.J.N.L.B.)
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F. Groenendaal
aFrom the Departments of Neonatology (K.V.A., N.E.v.d.A., J.D., T.A., F.G., M.J.N.L.B.)
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M. Lequin
cUniversity Medical Center Utrecht Brain Center, and the Departments of Radiology (M.L., P.L., J.H., H.J.M.H., E.R.H., E.V., F.V., A.J.E.R., E.C.W., D.W.J.K., J.P.W.)
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F.E. Jansen
bPaediatric Neurology (F.E.J.)
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K.S. Rhebergen
dOtorhinolaryngology and Head and Neck Surgery (K.S.R.), University Medical Center Utrecht, University Utrecht, Utrecht, the Netherlands.
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P. Luijten
cUniversity Medical Center Utrecht Brain Center, and the Departments of Radiology (M.L., P.L., J.H., H.J.M.H., E.R.H., E.V., F.V., A.J.E.R., E.C.W., D.W.J.K., J.P.W.)
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J. Hendrikse
cUniversity Medical Center Utrecht Brain Center, and the Departments of Radiology (M.L., P.L., J.H., H.J.M.H., E.R.H., E.V., F.V., A.J.E.R., E.C.W., D.W.J.K., J.P.W.)
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H.J.M. Hoogduin
cUniversity Medical Center Utrecht Brain Center, and the Departments of Radiology (M.L., P.L., J.H., H.J.M.H., E.R.H., E.V., F.V., A.J.E.R., E.C.W., D.W.J.K., J.P.W.)
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E.R. Huijing
cUniversity Medical Center Utrecht Brain Center, and the Departments of Radiology (M.L., P.L., J.H., H.J.M.H., E.R.H., E.V., F.V., A.J.E.R., E.C.W., D.W.J.K., J.P.W.)
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E. Versteeg
cUniversity Medical Center Utrecht Brain Center, and the Departments of Radiology (M.L., P.L., J.H., H.J.M.H., E.R.H., E.V., F.V., A.J.E.R., E.C.W., D.W.J.K., J.P.W.)
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F. Visser
cUniversity Medical Center Utrecht Brain Center, and the Departments of Radiology (M.L., P.L., J.H., H.J.M.H., E.R.H., E.V., F.V., A.J.E.R., E.C.W., D.W.J.K., J.P.W.)
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A.J.E. Raaijmakers
cUniversity Medical Center Utrecht Brain Center, and the Departments of Radiology (M.L., P.L., J.H., H.J.M.H., E.R.H., E.V., F.V., A.J.E.R., E.C.W., D.W.J.K., J.P.W.)
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E.C. Wiegers
cUniversity Medical Center Utrecht Brain Center, and the Departments of Radiology (M.L., P.L., J.H., H.J.M.H., E.R.H., E.V., F.V., A.J.E.R., E.C.W., D.W.J.K., J.P.W.)
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D.W.J. Klomp
cUniversity Medical Center Utrecht Brain Center, and the Departments of Radiology (M.L., P.L., J.H., H.J.M.H., E.R.H., E.V., F.V., A.J.E.R., E.C.W., D.W.J.K., J.P.W.)
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J.P. Wijnen
cUniversity Medical Center Utrecht Brain Center, and the Departments of Radiology (M.L., P.L., J.H., H.J.M.H., E.R.H., E.V., F.V., A.J.E.R., E.C.W., D.W.J.K., J.P.W.)
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M.J.N.L. Benders
aFrom the Departments of Neonatology (K.V.A., N.E.v.d.A., J.D., T.A., F.G., M.J.N.L.B.)
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  • FIG 1.
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    FIG 1.

    Different positions of the infant model in the radiofrequency coil. On the left, the adult head and torso are shown. They are used as a reference.

  • FIG 2.
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    FIG 2.

    Setup for measuring acoustic noise at the MR imaging table in the presence of the hood. This test setup consisted of a dummy bore with dimensions similar to those of the 7T MR system with a 10-mm plastic plate of polyoxymethylene to create an MR imaging table. The speakers producing the sound are positioned at 28-cm distance around the dummy bore to mimic the sound produced by the MR imaging scanner.

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    FIG 3.

    Local SAR levels in adult head (left) and Charlie in the different coil positions. Shifts of an infant in the x and y directions are unlikely because of limited space; therefore, the results are not included in the figure. The SAR values when infant Charlie is positioned 50 mm in the x or y direction are comparable with those in the +50-mm FH position.

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    FIG 4.

    Examples of images of different patients at 3T (upper row) versus 7T MR imaging (lower row). A and G , MRV at 3T and 7T, respectively, of a preterm infant at term-equivalent age. B and H, An SWI at, respectively, 3T and 7T of a preterm infant at term-equivalent age. C and I, The 6-week follow-up single-shot T2-weighted image of a term-born infant with a perinatal stroke. The arrows indicate perivascular spaces that were better visualized at 3T compared with 7T. D and J, A 3-month follow-up MRA at 3T and 7T of a term-born infant with an occipital stroke. E and K, T1WI (MPRAGE) of a preterm-born infant at term-equivalent age. F and L, An MR spectroscopy spectrum at 3T and 7T of a preterm infant at term-equivalent age, both with a comparable ROI in the left basal ganglia/thalami region.

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    Table 1:

    Global and peak SAR levels

    Duke CenteredElla CenteredCharlie CenteredCharlie −50-mm FHCharlie +50-mm FH
    Global SAR levels
     Average SAR for 1 Watt input  power (W kg−1)0.0660.0690.0620.0500.075
     Average SAR per B12 (W kg−1 µT–2)0.4620.4650.2890.4540.474
     Average B1+ in central section  for 1 Watt input power (µT)a0.3790.3850.4660.3330.398
    Peak local SAR levels
     Peak local SAR (10-g averaged)  for 1 Watt input power (W kg−1)0.4350.3980.3210.2130.487
     Peak local SAR (10-g averaged)  per B12 (W kg−1µT–2)3.042.631.481.923.08
    • ↵a The power optimization procedure of the MR imaging scanner software calibrates the needed input power to achieve a certain B1 in the subject. This calibration is based on the average B1+ in a central section of the subject (brain in this case).

    • View popup
    Table 2:

    Acoustic noise levels in decibel(A), with use of no hood, the 3T hood, and the newly developed 7T hood

    Both Ends of the BoreSides of the BoreSides and Ends of the Bore
    No hood for acoustic noise protection60.0 dB(A)58.5 dB(A)62.5 dB(A)
    3T Nordell hood for acoustic noise protection54.0 dB(A)51.0 dB(A)55.5 dB(A)
    Prototype 7T hood for acoustic noise protection54.0 dB(A)43.0 dB(A)54.0 dB(A)
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Cite this article
K.V. Annink, N.E. van der Aa, J. Dudink, T. Alderliesten, F. Groenendaal, M. Lequin, F.E. Jansen, K.S. Rhebergen, P. Luijten, J. Hendrikse, H.J.M. Hoogduin, E.R. Huijing, E. Versteeg, F. Visser, A.J.E. Raaijmakers, E.C. Wiegers, D.W.J. Klomp, J.P. Wijnen, M.J.N.L. Benders
Introduction of Ultra-High-Field MR Imaging in Infants: Preparations and Feasibility
American Journal of Neuroradiology Jul 2020, DOI: 10.3174/ajnr.A6702

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Introduction of Ultra-High-Field MR Imaging in Infants: Preparations and Feasibility
K.V. Annink, N.E. van der Aa, J. Dudink, T. Alderliesten, F. Groenendaal, M. Lequin, F.E. Jansen, K.S. Rhebergen, P. Luijten, J. Hendrikse, H.J.M. Hoogduin, E.R. Huijing, E. Versteeg, F. Visser, A.J.E. Raaijmakers, E.C. Wiegers, D.W.J. Klomp, J.P. Wijnen, M.J.N.L. Benders
American Journal of Neuroradiology Jul 2020, DOI: 10.3174/ajnr.A6702
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