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Research ArticlePediatric Neuroimaging

Intra-Arterial Chemotherapy for Retinoblastoma in Infants ≤10 kg: 74 Treated Eyes with 222 IAC Sessions

A. Sweid, B. Hammoud, J.H. Weinberg, P. Texakalidis, V. Xu, K. Shivashankar, M.P. Baldassari, S. Das, S. Ramesh, S. Tjoumakaris, C.L. Shields, D. Ancona-Lezama, L.-A.S. Lim, L.A. Dalvin and P. Jabbour
American Journal of Neuroradiology June 2020, DOI: https://doi.org/10.3174/ajnr.A6590
A. Sweid
aFrom the Department of Neurosurgery (A.S., J.H.W., V.X., K.S., M.P.B., S.D., S.R., S.T., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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B. Hammoud
bDepartment of Pediatric Endocrinology (B.H.), Children Hospital of Philadelphia, Philadelphia, Pennsylvania
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J.H. Weinberg
aFrom the Department of Neurosurgery (A.S., J.H.W., V.X., K.S., M.P.B., S.D., S.R., S.T., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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P. Texakalidis
cDepartment of Neurosurgery (P.T.), Emory University School of Medicine, Atlanta, Georgia
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V. Xu
aFrom the Department of Neurosurgery (A.S., J.H.W., V.X., K.S., M.P.B., S.D., S.R., S.T., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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K. Shivashankar
aFrom the Department of Neurosurgery (A.S., J.H.W., V.X., K.S., M.P.B., S.D., S.R., S.T., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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M.P. Baldassari
aFrom the Department of Neurosurgery (A.S., J.H.W., V.X., K.S., M.P.B., S.D., S.R., S.T., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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S. Das
aFrom the Department of Neurosurgery (A.S., J.H.W., V.X., K.S., M.P.B., S.D., S.R., S.T., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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S. Ramesh
aFrom the Department of Neurosurgery (A.S., J.H.W., V.X., K.S., M.P.B., S.D., S.R., S.T., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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S. Tjoumakaris
aFrom the Department of Neurosurgery (A.S., J.H.W., V.X., K.S., M.P.B., S.D., S.R., S.T., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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C.L. Shields
dOcular Oncology Service (C.L.S., D.A.-L., L.-A.S.L., L.A.D.), Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania
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D. Ancona-Lezama
dOcular Oncology Service (C.L.S., D.A.-L., L.-A.S.L., L.A.D.), Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania
eOcular Oncology Service (D.A.-L.), Instituto de Oftalmologia y Ciencias Visuales, Tecnologico de Monterrey, Monterrey, Mexico
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L.-A.S. Lim
dOcular Oncology Service (C.L.S., D.A.-L., L.-A.S.L., L.A.D.), Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania
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L.A. Dalvin
dOcular Oncology Service (C.L.S., D.A.-L., L.-A.S.L., L.A.D.), Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania
fDepartment of Ophthalmology (L.A.D.), Mayo Clinic, Rochester, Minnesota.
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P. Jabbour
aFrom the Department of Neurosurgery (A.S., J.H.W., V.X., K.S., M.P.B., S.D., S.R., S.T., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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References

  1. 1.↵
    1. Schefler AC,
    2. Kim RS
    . Recent advancements in the management of retinoblastoma and uveal melanoma. F1000Res 2018;7:476 doi:10.12688/f1000research.11941.1
    CrossRef
  2. 2.↵
    1. Kivelä T
    . The Epidemiological Challenge of the Most Frequent Eye Cancer: Retinoblastoma, An Issue of Birth and Death. BMJ Publishing Group Ltd; 2009
  3. 3.↵
    1. Abramson DH,
    2. Shields CL,
    3. Munier FL, et al
    . Treatment of retinoblastoma in 2015: agreement and disagreement. JAMA Ophthalmol 2015;133:1341–47 doi:10.1001/jamaophthalmol.2015.3108 pmid:26378747
    CrossRefPubMed
  4. 4.↵
    1. Shields CL,
    2. Bianciotto CG,
    3. Jabbour P, et al
    . Intra-arterial chemotherapy for retinoblastoma: report No. 1, control of retinal tumors, subretinal seeds, and vitreous seeds. Arch Ophthalmol 2011;129:1399–1406 doi:10.1001/archophthalmol.2011.150 pmid:21670328
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Shields CL,
    2. Jorge R,
    3. Say EAT, et al
    . Unilateral retinoblastoma managed with intravenous chemotherapy versus intra-arterial chemotherapy. Outcomes based on the International Classification of Retinoblastoma. Asia Pac J Ophthalmol (Phila) 2016;5:97–103
  6. 6.↵
    1. Shields CL,
    2. Kaliki S,
    3. Shah SU, et al
    . Minimal exposure (one or two cycles) of intra-arterial chemotherapy in the management of retinoblastoma. Ophthalmology 2012;119:188–92 doi:10.1016/j.ophtha.2011.06.036 pmid:21975042
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Shields CL,
    2. Manjandavida FP,
    3. Lally SE, et al
    . Intra-arterial chemotherapy for retinoblastoma in 70 eyes: outcomes based on the International Classification of Retinoblastoma. Ophthalmology 2014;121:1453–60 doi:10.1016/j.ophtha.2014.01.026
    CrossRefPubMed
  8. 8.↵
    1. Shields CL,
    2. Mashayekhi A,
    3. Au AK, et al
    . The International Classification of Retinoblastoma predicts chemoreduction success. Ophthalmology 2006;113:2276–80 doi:10.1016/j.ophtha.2006.06.018
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Gobin P,
    2. Marr B,
    3. Dunkel I, et al
    . Intra-arterial chemotherapy (chemosurgery) in the ophthalmic artery for the treatment of retinoblastoma in children: 3 year experience. J Neurointerv Surg 2009;1:77–78 doi:10.1136/jnis.2009.000851n
    FREE Full Text
  10. 10.↵
    1. Abramson DH,
    2. Daniels AB,
    3. Marr BP, et al
    . Intra-arterial chemotherapy (ophthalmic artery chemosurgery) for group D retinoblastoma. PLoS One 2016;11:e0146582 doi:10.1371/journal.pone.0146582 pmid:26756643
    CrossRefPubMed
  11. 11.↵
    1. Yamane T,
    2. Kaneko A,
    3. Mohri M
    . The technique of ophthalmic arterial infusion therapy for patients with intraocular retinoblastoma. Int J Clin Oncol 2004;9:69–73 doi:10.1007/s10147-004-0392-6 pmid:15108036
    CrossRefPubMed
  12. 12.↵
    1. Abramson DH,
    2. Dunkel IJ,
    3. Brodie SE, et al
    . A phase I/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma: initial results. Ophthalmology 2008;115:1398–1404,e1391 doi:10.1016/j.ophtha.2007.12.014 pmid:18342944
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Abramson DH,
    2. Marr BP,
    3. Francis JH, et al
    . Simultaneous bilateral ophthalmic artery chemosurgery for bilateral retinoblastoma (tandem therapy). PLoS One 2016;11:e0156806 doi:10.1371/journal.pone.0156806 pmid:27258771
    CrossRefPubMed
  14. 14.↵
    1. Shields CL,
    2. Bianciotto CG,
    3. Jabbour P, et al
    . Intra-arterial chemotherapy for retinoblastoma: report No. 2, treatment complications. Arch Ophthalmol 2011;129:1407–15 doi:10.1001/archophthalmol.2011.151 pmid:21670326
    CrossRefPubMed
  15. 15.↵
    1. Shields CL,
    2. Alset AE,
    3. Say EAT, et al
    . Retinoblastoma control with primary intra-arterial chemotherapy: outcomes before and during the intravitreal chemotherapy era. J Pediatr Ophthalmol Strabismus 2016;53:275–84 doi:10.3928/01913913-20160719-04 pmid:27486728
    CrossRefPubMed
  16. 16.↵
    1. Dalvin LA,
    2. Kumari M,
    3. Essuman VA, et al
    . Primary intra-arterial chemotherapy for retinoblastoma in the intravitreal chemotherapy era: five years of experience. Oncol Pathol 2019;5:139–46 doi:10.1159/000491580
    CrossRef
  17. 17.↵
    1. Kim RS,
    2. Dannenbaum MJ,
    3. Lin MW, et al
    . Use of femoral artery ultrasound during intraarterial chemotherapy for children under 10 kg with retinoblastoma. Retina 2018;38:1420–26
  18. 18.↵
    1. Magan T,
    2. Khoo CT,
    3. Jabbour PM, et al
    . Intraarterial chemotherapy for retinoblastoma in a 2-month-old infant. Retin Cases Brief Rep 2017;11:24–26
  19. 19.↵
    1. Abramson DH,
    2. Fabius AW,
    3. Issa R, et al
    . Advanced unilateral retinoblastoma: the impact of ophthalmic artery chemosurgery on enucleation rate and patient survival at MSKCC. PloS One 2015;10:e0145436 doi:10.1371/journal.pone.0145436 pmid:26709699
    CrossRefPubMed
  20. 20.
    1. Abramson DH,
    2. Shields CL,
    3. Jabbour P, et al
    . Metastatic deaths in retinoblastoma patients treated with intraarterial chemotherapy (ophthalmic artery chemosurgery) worldwide. Int J Retin Vitr 2017;3:40 doi:10.1186/s40942-017-0093-8
    CrossRef
  21. 21.↵
    1. Munier FL,
    2. Mosimann P,
    3. Puccinelli F, et al
    . First-line intra-arterial versus intravenous chemotherapy in unilateral sporadic group D retinoblastoma: evidence of better visual outcomes, ocular survival and shorter time to success with intra-arterial delivery from retrospective review of 20 years of treatment. Br J Ophthalmol 2017;101:1086–93 doi:10.1136/bjophthalmol-2016-309298
    Abstract/FREE Full Text
  22. 22.↵
    1. Gobin YP,
    2. Dunkel IJ,
    3. Marr BP, et al
    . Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience. Arch Ophthalmol 2011;129:732–37 doi:10.1001/archophthalmol.2011.5 pmid:21320950
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Chen M,
    2. Zhao J,
    3. Xia J, et al
    . Intra-arterial chemotherapy as primary therapy for retinoblastoma in infants less than 3 months of age: a series of 10 case-studies. PLoS One 2016;11:e0160873 doi:10.1371/journal.pone.0160873 pmid:27504917
    CrossRefPubMed
  24. 24.↵
    1. Daniels AB,
    2. Froehler MT,
    3. Pierce JM, et al
    . Pharmacokinetics, tissue localization, toxicity, and treatment efficacy in the first small animal (rabbit) model of intra-arterial chemotherapy for retinoblastoma. Invest Ophthalmol Vis Sci 2018;59:446–54 doi:10.1167/iovs.17-22302 pmid:29368001
    CrossRefPubMed
  25. 25.↵
    1. Franken E Jr.,
    2. Girod D,
    3. Sequeira F, et al
    . Femoral artery spasm in children: catheter size is the principal cause. AJR Am J Roentgenol 1982;138:295–98 doi:10.2214/ajr.138.2.295 pmid:6976734
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Burrows PE,
    2. Benson LN,
    3. Williams WG, et al
    . Iliofemoral arterial complications of balloon angioplasty for systemic obstructions in infants and children. Circulation 1990;82:1697–1704 doi:10.1161/01.cir.82.5.1697 pmid:2146039
    Abstract/FREE Full Text
  27. 27.↵
    1. Burrows PE,
    2. Benson LN,
    3. Babyn P, et al
    . Magnetic resonance imaging of the iliofemoral arteries after balloon dilation angioplasty of aortic arch obstructions in children. Circulation 1994;90:915–20 doi:10.1161/01.CIR.90.2.915
    Abstract/FREE Full Text
  28. 28.↵
    1. Perry M
    . Iatrogenic injuries of arteries in infants. Surg Gynecol Obstet 1983;157:415–18 pmid:6635911
    PubMedWeb of Science
  29. 29.↵
    1. Fullilove S,
    2. Fixsen J
    . Major limb deformities as complications of vascular access in neonates. Paediatr Anaesth 1997;7:247–50 doi:10.1111/pan.1997.7.3.247 pmid:9189973
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Macnicol M,
    2. Anagnostopoulos J
    . Arrest of the growth plate after arterial cannulation in infancy. J Bone Joint Surg Br 2000;82:172–75 doi:10.1302/0301-620x.82b2.9956 pmid:10755421
    CrossRefPubMed
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A. Sweid, B. Hammoud, J.H. Weinberg, P. Texakalidis, V. Xu, K. Shivashankar, M.P. Baldassari, S. Das, S. Ramesh, S. Tjoumakaris, C.L. Shields, D. Ancona-Lezama, L.-A.S. Lim, L.A. Dalvin, P. Jabbour
Intra-Arterial Chemotherapy for Retinoblastoma in Infants ≤10 kg: 74 Treated Eyes with 222 IAC Sessions
American Journal of Neuroradiology Jun 2020, DOI: 10.3174/ajnr.A6590

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Intra-Arterial Chemotherapy for Retinoblastoma in Infants ≤10 kg: 74 Treated Eyes with 222 IAC Sessions
A. Sweid, B. Hammoud, J.H. Weinberg, P. Texakalidis, V. Xu, K. Shivashankar, M.P. Baldassari, S. Das, S. Ramesh, S. Tjoumakaris, C.L. Shields, D. Ancona-Lezama, L.-A.S. Lim, L.A. Dalvin, P. Jabbour
American Journal of Neuroradiology Jun 2020, DOI: 10.3174/ajnr.A6590
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