Diffusion-Weighted MR Imaging in a Prospective Cohort of Children with Cerebral Malaria Offers Insights into Pathophysiology and Prognosis

REFERENCES

1. 1.↵
   World Health Organization. World malaria report 2018. License: CC BY-NC-SA 3.0 IGO. https://www.who.int/malaria/publications/world_malaria_report/en/. Accessed April 10, 2019
2. 2.↵
   2. Lopera-Mesa TM,
   3. Doumbia S,
   4. Chiang S, et al

   . Plasmodium falciparum clearance rates in response to artesunate in Malian children with malaria: effect of acquired immunity. J Infect Dis 2013;207:1655–63 doi:10.1093/infdis/jit082 pmid:23448727

   CrossRefPubMed
3. 3.↵
   2. Milner DA Jr.

   . Rethinking cerebral malaria pathology. Curr Opin Infect Dis 2010;23:456–63 doi:10.1097/QCO.0b013e32833c3dbe pmid:20613511

   CrossRefPubMed
4. 4.↵
   2. Dorovini-Zis K,
   3. Schmidt K,
   4. Huynh H, et al

   . The neuropathology of fatal cerebral malaria in Malawian children. Am J Pathol 2011;178:2146–58 doi:10.1016/j.ajpath.2011.01.016 pmid:21514429

   CrossRefPubMedWeb of Science
5. 5.↵
   2. Potchen MJ,
   3. Kampondeni SD,
   4. Seydel KB, et al

   . Acute brain MRI findings in 120 Malawian children with cerebral malaria: new insights into an ancient disease. AJNR Am J Neuroradiol 2012;33:1740–46 doi:10.3174/ajnr.A3035 pmid:22517285

   Abstract/FREE Full Text
6. 6.↵
   2. Seydel KB,
   3. Kampondeni SD,
   4. Valim C, et al

   . Brain swelling and death in children with cerebral malaria. N Engl J Med 2015;372:1126–37 doi:10.1056/NEJMoa1400116 pmid:25785970

   CrossRefPubMed
7. 7.↵
   2. Kampondeni SD,
   3. Potchen MJ,
   4. Beare NA, et al

   . MRI findings in a cohort of brain injured survivors of pediatric cerebral malaria. Am J Trop Med Hyg 2013;88:542–46 doi:10.4269/ajtmh.12-0538 pmid:23339204

   Abstract/FREE Full Text
8. 8.↵
   2. Postels DG,
   3. Li C,
   4. Birbeck GL, et al

   . Brain MRI of children with retinopathy-negative cerebral malaria. Am J Trop Med Hyg 2014;91:943–49 doi:10.4269/ajtmh.14-0216 pmid:25200262

   Abstract/FREE Full Text
9. 9.↵
   2. Zhuang Y,
   3. Potchen MJ,
   4. Kampondeni SD, et al

   . Validation of diffusion measurements obtained on a 0.35T MR in Malawi: important insights for radiologists in low income settings with low field MRI. Magn Reson Imaging 2018;45:120–28 doi:10.1016/j.mri.2017.10.001 pmid:29031584

   CrossRefPubMed
10. 10.↵
    2. Moritani T,
    3. Smoker WR,
    4. Sato Y, et al

    . Diffusion-weighted imaging of acute excitotoxic brain injury. AJNR Am J Neuroradiol 2005;26:216–28 pmid:15709116

    FREE Full Text
11. 11.↵
    2. Hassel B,
    3. Boldingh KA,
    4. Narvesen C, et al

    . Glutamate transport, glutamine synthetase and phosphate-activated glutaminase in rat CNS white matter: a quantitative study. J Neurochem 2003;87:230–37 doi:10.1046/j.1471-4159.2003.01984.x pmid:12969269

    CrossRefPubMed
12. 12.↵
    2. Liang D,
    3. Bhatta S,
    4. Gerzanich V, et al

    . Cytotoxic edema: mechanisms of pathological cell swelling. Neurosurg Focus 2007;22:E2 pmid:17613233

    PubMed
13. 13.↵
    2. Sato A,
    3. Shimizu Y,
    4. Koyama J, et al

    . A new threshold of apparent diffusion coefficient values in white matter after successful tissue plasminogen activator treatment for acute brain ischemia. J Neuroradiol 2017;44:223–26 doi:10.1016/j.neurad.2016.12.003 pmid:28187865

    CrossRefPubMed
14. 14.↵
    2. Chalela JA,
    3. Wolf RL,
    4. Maldjian JA, et al

    . MRI identification of early white matter injury in anoxic-ischemic encephalopathy. Neurology 2001;56:481–85 doi:10.1212/WNL.56.4.481 pmid:11222791

    Abstract/FREE Full Text
15. 15.↵
    2. Zheng WB,
    3. Liu GR,
    4. Li LP, et al

    . Prediction of recovery from a post-traumatic coma state by diffusion-weighted imaging (DWI) in patients with diffuse axonal injury. Neuroradiology 2007;49:271–79 doi:10.1007/s00234-006-0187-8 pmid:17203299

    CrossRefPubMedWeb of Science
16. 16.↵
    2. McKinney AM,
    3. Kieffer SA,
    4. Paylor RT, et al

    . Acute toxic leukoencephalopathy: potential for reversibility clinically and on MRI with diffusion-weighted and FLAIR imaging. AJR Am J Roentgenol 2009;193:192–206 doi:10.2214/AJR.08.1176 pmid:19542414

    CrossRefPubMedWeb of Science
17. 17.↵
    2. Maheen Anwar SS,
    3. Mubarak F,
    4. Sajjad Z, et al

    . 5-FU induced acute toxic leukoencephalopathy: early recognition and reversibility on DWI-MRI. J Coll Physicians Surg Pak 2014;24(Suppl 1):S8–10 doi:03.2014/JCPSP.S8S10 pmid:24718016

    CrossRefPubMed
18. 18.↵
    2. Koelman DL,
    3. Benkeser DC,
    4. Klein JP, et al

    . Acute disseminated encephalomyelitis: prognostic value of early follow-up brain MRI. J Neurol 2017;264:1754–62 doi:10.1007/s00415-017-8563-3 pmid:28695361

    CrossRefPubMed
19. 19.↵
    2. Barnett MH,
    3. Miller LA,
    4. Reddel SW, et al

    . Reversible delayed leukoencephalopathy following intravenous heroin overdose. J Clin Neurosci 2001;8:165–67 doi:10.1054/jocn.2000.0769 pmid:11243768

    CrossRefPubMedWeb of Science
20. 20.↵
    2. Cianfoni A,
    3. Caulo M,
    4. Cerase A, et al

    . Seizure-induced brain lesions: a wide spectrum of variably reversible MRI abnormalities. Eur J Radiol 2013;82:1964–72 doi:10.1016/j.ejrad.2013.05.020 pmid:23787273

    CrossRefPubMed
21. 21.↵
    2. Kang EG,
    3. Jeon SJ,
    4. Choi SS, et al

    . Diffusion MR imaging of hypoglycemic encephalopathy. AJNR Am J Neuroradiol 2010;31:559–64 doi:10.3174/ajnr.A1856 pmid:19875472

    Abstract/FREE Full Text
22. 22.↵
    2. Pearl PL,
    3. Vezina LG,
    4. Saneto RP, et al

    . Cerebral MRI abnormalities associated with vigabatrin therapy. Epilepsia 2009;50:184–94 doi:10.1111/j.1528-1167.2008.01728.x pmid:18783433

    CrossRefPubMed
23. 23.↵
    2. Newton CR,
    3. Chokwe T,
    4. Schellenberg JA, et al

    . Coma scales for children with severe falciparum malaria. Trans R Soc Trop Med Hyg 1997;91:161–65 doi:10.1016/S0035-9203(97)90207-8 pmid:9196757

    CrossRefPubMed
24. 24.↵
    2. Molyneux ME,
    3. Taylor TE,
    4. Wirima JJ, et al

    . Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med 1989;71:441–59 pmid:2690177

    PubMed
25. 25.↵
    2. Taylor TE,
    3. Molyneux ME

    . The pathogenesis of pediatric cerebral malaria: eye exams, autopsies, and neuroimaging. Ann N Y Acad Sci 2015;1342:44–52 doi:10.1111/nyas.12690 pmid:25708306

    CrossRefPubMed
26. 26.↵
    2. Dondorp AM,
    3. Desakorn V,
    4. Pongtavornpinyo W, et al

    . Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2. PLoS Med 2005;2:e204 doi:10.1371/journal.pmed.0020204 pmid:16104831

    CrossRefPubMed
27. 27.↵
    2. Potchen MJ,
    3. Kampondeni SD,
    4. Ibrahim K, et al

    . NeuroInterp: a method for facilitating neuroimaging research on cerebral malaria. Neurology 2013;81:585–88 doi:10.1212/WNL.0b013e31829e6ed5 pmid:23918861

    Abstract/FREE Full Text
28. 28.↵
    2. Helenius J,
    3. Soinne L,
    4. Perkiö J, et al

    . Diffusion-weighted MR imaging in normal human brains in various age groups. AJNR Am J Neuroradiol 2002;23:194–99 pmid:11847041

    Abstract/FREE Full Text
29. 29.↵
    2. Postels DG,
    3. Wu X,
    4. Li C, et al

    . Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes. Malar J 2018;17:208 doi:10.1186/s12936-018-2355-9 pmid:29783991

    CrossRefPubMed
30. 30.↵
    2. Aoki T,
    3. Sato T,
    4. Hasegawa K, et al

    . Reversible hyperintensity lesion on diffusion-weighted MRI in hypoglycemic coma. Neurology 2004;63:392–93 doi:10.1212/01.WNL.0000130181.05016.68 pmid:15277649

    Abstract/FREE Full Text
31. 31.↵
    2. Idro R,
    3. Marsh K,
    4. John CC, et al

    . Cerebral malaria: mechanisms of brain injury and strategies for improved neurocognitive outcome. Pediatr Res 2010;68:267–74 doi:10.1203/00006450-201011001-00524 pmid:20606600

    CrossRefPubMedWeb of Science
32. 32.↵
    2. Rimkus Cde M,
    3. Andrade CS,
    4. Leite Cda C, et al

    . Toxic leukoencephalopathies, including drug, medication, environmental, and radiation-induced encephalopathic syndromes. Semin Ultrasound CT MR 2014;35:97–117 doi:10.1053/j.sult.2013.09.005 pmid:24745887

    CrossRefPubMed
33. 33.↵
    2. Gupta S,
    3. Seydel K,
    4. Miranda-Roman MA, et al

    . Extensive alterations of blood metabolites in pediatric cerebral malaria. PLoS One 2017;12:e0175686 doi:10.1371/journal.pone.0175686 pmid:28426698

    CrossRefPubMed
34. 34.↵
    2. Terakawa Y,
    3. Tsuyuguchi N,
    4. Nunomura K, et al

    . Reversible diffusion-weighted imaging changes in the splenium of the corpus callosum and internal capsule associated with hypoglycemia: case report. Neurol Med Chir (Tokyo) 2007;47:486–88 doi:10.2176/nmc.47.486 pmid:17965569

    CrossRefPubMed
35. 35.↵
    2. Schmidt P,
    3. Böttcher J,
    4. Ragoschke-Schumm A, et al

    . Diffusion-weighted imaging of hyperacute cerebral hypoglycemia. AJNR Am J Neuroradiol 2011;32:1321–27 doi:10.3174/ajnr.A2464 pmid:21511866

    Abstract/FREE Full Text
36. 36.↵
    2. Sharma HS

    . Methods to produce brain hyperthermia. Current Protocols in Toxicology; 2005;23:11.14.1–11.14.26
37. 37.↵
    2. Pantoni L,
    3. Garcia JH,
    4. Gutierrez JA

    . Cerebral white matter is highly vulnerable to ischemia. Stroke 1996;27:1641–46; discussion 1647 doi:10.1161/01.STR.27.9.1641 pmid:8784142

    Abstract/FREE Full Text
38. 38.
    2. Conroy AL,
    3. Phiri H,
    4. Hawkes M, et al

    . Endothelium-based biomarkers are associated with cerebral malaria in Malawian children: a retrospective case-control study. PLoS One 2010;5:e15291 doi:10.1371/journal.pone.0015291 pmid:21209923

    CrossRefPubMed
39. 39.
    2. Taylor TE,
    3. Molyneux ME,
    4. Wirima JJ, et al

    . Blood glucose levels in Malawian children before and during the administration of intravenous quinine for severe falciparum malaria. N Engl J Med 1988;319:1040–47 doi:10.1056/NEJM198810203191602 pmid:3050516

    CrossRefPubMedWeb of Science
40. 40.
    2. Xiang T,
    3. Li G,
    4. Liang Y, et al

    . A wide spectrum of variably periictal MRI abnormalities induced by a single or a cluster of seizures. J Neurol Sci 2014;343:167–72 doi:10.1016/j.jns.2014.06.001 pmid:24950900

    CrossRefPubMed
41. 41.
    2. Love S

    . Demyelinating diseases. J Clin Pathol 2006;59:1151–59 doi:10.1136/jcp.2005.031195 pmid:17071802

    Abstract/FREE Full Text