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Research ArticleSpine Imaging and Spine Image-Guided Interventions
Open Access

Lumbar Spinal Stenosis Severity by CT or MRI Does Not Predict Response to Epidural Corticosteroid versus Lidocaine Injections

F.A. Perez, S. Quinet, J.G. Jarvik, Q.T. Nguyen, E. Aghayev, D. Jitjai, W.D. Hwang, E.R. Jarvik, S.S. Nedeljkovic, A.L. Avins, J.M. Schwalb, F.E. Diehn, C.J. Standaert, D.R. Nerenz, T. Annaswamy, Z. Bauer, D. Haynor, P.J. Heagerty and J.L. Friedly
American Journal of Neuroradiology May 2019, DOI: https://doi.org/10.3174/ajnr.A6050
F.A. Perez
aFrom the Department of Radiology (F.A.P., J.G.J., Q.T.N., D.H.)
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S. Quinet
hDepartment of Radiology (S.Q.), College of Wisconsin, Milwaukee, Wisconsin
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J.G. Jarvik
aFrom the Department of Radiology (F.A.P., J.G.J., Q.T.N., D.H.)
bComparative Effectiveness, Cost and Outcomes Research Center (J.G.J., P.J.H., J.L.F.)
cDepartments of Neurological Surgery (J.G.J.)
dHealth Services (J.G.J.)
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Q.T. Nguyen
aFrom the Department of Radiology (F.A.P., J.G.J., Q.T.N., D.H.)
eOrthopedics and Sports Medicine (Q.T.N.)
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E. Aghayev
iSpinal Centre Division (E.A.), Schulthess Klinik, Zurich, Switzerland
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D. Jitjai
jOregon Health Sciences University (D.J.) Portland, Oregon
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W.D. Hwang
kTRA Medical Imaging (W.D.H.), Tacoma, Washington
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E.R. Jarvik
lUniversity of Washington Medicine (E.R.J.), Seattle, Washington
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S.S. Nedeljkovic
mDepartment of Anesthesiology, Perioperative and Pain Medicine and Spine Unit (S.S.N.), Harvard Vanguard Medical Associates, Brigham and Women's Hospital, Boston, Massachusetts
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A.L. Avins
nDivision of Research (A.L.A.), Kaiser Permanente Northern California, Oakland, California
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J.M. Schwalb
oDepartment of Neurosurgery (J.M.S., D.R.N.), Henry Ford Medical Group, Detroit, Michigan
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F.E. Diehn
pDepartment of Radiology (F.E.D.), Mayo Clinic, Rochester, Minnesota
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C.J. Standaert
qDepartment of Physical Medicine and Rehabilitation (C.J.S.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
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D.R. Nerenz
oDepartment of Neurosurgery (J.M.S., D.R.N.), Henry Ford Medical Group, Detroit, Michigan
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T. Annaswamy
rDepartment of Physical Medicine and Rehabilitation (T.A.), VA North Texas Healthcare System, Dallas, Texas
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Z. Bauer
sCancer and Blood Disorders Center (Z.B.), Seattle Children's Research Institute, Seattle, Washington.
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D. Haynor
aFrom the Department of Radiology (F.A.P., J.G.J., Q.T.N., D.H.)
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P.J. Heagerty
bComparative Effectiveness, Cost and Outcomes Research Center (J.G.J., P.J.H., J.L.F.)
fBiostatistics (P.J.H.)
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J.L. Friedly
bComparative Effectiveness, Cost and Outcomes Research Center (J.G.J., P.J.H., J.L.F.)
gRehabilitation Medicine (J.L.F.), University of Washington, Seattle, Washington
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    Fig 1.

    Mean and 95% CI for the RDQ disability score (A) and the leg pain NRS (B) are presented at baseline, 3 weeks, and 6 weeks following epidural injection, including all patients regardless of injectate type, and subdivided by the severity of spinal stenosis on imaging (mild = solid line with circle; moderate = dash line with square; severe = dotted line with triangle). Patients with moderate stenosis demonstrated slightly greater improvement in disability scores at 3 weeks and leg pain scores at 3 and 6 weeks compared with patients with mild stenosis.

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    Fig 2.

    Mean and 95% CI RDQ disability score (A) and leg pain NRS (B) at baseline, 3 weeks, and 6 weeks after epidural injection are presented for patients randomized to lidocaine alone (circles and solid line) and corticosteroid and lidocaine (squares and dotted line), subdivided by the severity of qualitative spinal stenosis on imaging (mild, moderate, and severe). There were no differences in responses when taking into account spinal stenosis severity.

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    Fig 3.

    Change in the RDQ disability score (A) and leg pain NRS (B) at 3 weeks is presented as a function of minimum thecal sac cross-sectional area subdivided by injectate type with locally weighted scatterplot smoothing lines and 95% CI bands. The degree of spinal stenosis as assessed quantitatively was not associated with differential improvement between patients receiving lidocaine alone and corticosteroid and lidocaine. Min indicates minimum.

Tables

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  • Summary of patient baseline clinical and imaging characteristicsa

    Lidocaine (n = 175)Corticosteroid and Lidocaine (n = 175)
    Patient demographics
        Female53% (93/175)57% (100/175)
        Age range; mean (SD)50–96; 68 (9.9)50–89; 68 (9.6)
        Baseline clinical measures
            RDQ disability score15.6 (4.3)16.1 (4.5)
            Leg pain NRS7.2 (1.7)7.1 (1.9)
            Back pain NRS6.6 (2.6)6.6 (2.4)
            Mean of leg and back pain NRS6.6 (1.2)6.5 (1.5)
            SSSQ symptom subscale score3.1 (0.6)3.2 (0.6)
            SSSQ physical function subscale score2.5 (0.5)2.5 (0.5)
    Injection characteristics
        Interlaminar approach68% (119/175)69% (120/175)
        Transforaminal approach32% (56/175)31% (55/175)
        Mean lumbar level distance from injection to level of qualitative worst stenosis0.6 (0.6)0.5 (0.7)
    Qualitative CT and MRIn = 175n = 175
        Measures
            Maximum qualitative central stenosis2.2 (0.8)2.3 (0.9)
            Mean qualitative central stenosis1.2 (0.4)1.2 (0.5)
        Qualitative MRI measuresn = 150n = 158
            Maximum qualitative CSF effacement2.0 (1.1)2.0 (1.1)
            Mean qualitative CSF effacement0.7 (0.6)0.7 (0.6)
        Quantitative MRI measuresn = 148n = 156
            Minimum thecal sac cross-sectional area (mm2)72 (38)73 (39)
            Mean thecal sac cross-sectional (mm2)130 (40)130 (38)
            Minimum thecal sac AP diameter on axial images (mm)7.2 (2.5)7.2 (2.4)
            Mean thecal sac AP diameter on axial images (mm)10.6 (2.0)10.5 (2.0)
            Minimum thecal sac AP diameter on sagittal images (mm)6.2 (2.3)6.4 (2.4)
            Mean thecal sac AP diameter on sagittal images (mm)9.5 (2.0)9.6 (2.0)
            Minimum thecal sac ML diameter (mm)11.6 (3.2)11.6 (3.1)
            Mean thecal sac ML diameter (mm)16.1 (2.7)16.1 (2.5)
    • Note:—SSSQ indicates Swiss Spinal Stenosis Questionnaire.

    • ↵a Values represent mean and SD unless otherwise specified.

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F.A. Perez, S. Quinet, J.G. Jarvik, Q.T. Nguyen, E. Aghayev, D. Jitjai, W.D. Hwang, E.R. Jarvik, S.S. Nedeljkovic, A.L. Avins, J.M. Schwalb, F.E. Diehn, C.J. Standaert, D.R. Nerenz, T. Annaswamy, Z. Bauer, D. Haynor, P.J. Heagerty, J.L. Friedly
Lumbar Spinal Stenosis Severity by CT or MRI Does Not Predict Response to Epidural Corticosteroid versus Lidocaine Injections
American Journal of Neuroradiology May 2019, DOI: 10.3174/ajnr.A6050

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Lumbar Spinal Stenosis Severity by CT or MRI Does Not Predict Response to Epidural Corticosteroid versus Lidocaine Injections
F.A. Perez, S. Quinet, J.G. Jarvik, Q.T. Nguyen, E. Aghayev, D. Jitjai, W.D. Hwang, E.R. Jarvik, S.S. Nedeljkovic, A.L. Avins, J.M. Schwalb, F.E. Diehn, C.J. Standaert, D.R. Nerenz, T. Annaswamy, Z. Bauer, D. Haynor, P.J. Heagerty, J.L. Friedly
American Journal of Neuroradiology May 2019, DOI: 10.3174/ajnr.A6050
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