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Research ArticlePediatric Neuroimaging

Measuring Cerebral and Cerebellar Glutathione in Children Using 1H MEGA-PRESS MRS

F. Raschke, R. Noeske, R.A Dineen and D.P. Auer
American Journal of Neuroradiology December 2017, DOI: https://doi.org/10.3174/ajnr.A5457
F. Raschke
aFrom the National Center for Tumor Diseases (F.R.), Partner Site Dresden, Dresden, Germany
bGerman Cancer Research Center (F.R.), Heidelberg, Germany
cMedical Faculty and University Hospital Carl Gustav Carus (F.R.), Technische Universität Dresden, Dresden, Germany
dHelmholtz Association/Helmholtz Zentrum Dresden Rossendorf (F.R.), Dresden, Germany
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R. Noeske
eGE Healthcare (R.N.), Applied Science Lab Europe, Berlin, Germany
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R.A Dineen
fSir Peter Mansfield Imaging Centre (R.A.D., D.P.A.), University of Nottingham, Nottingham, UK
gRadiological Sciences, (R.A.D., D.P.A.), Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK
hNational Institute for Health Research (R.A.D., D.P.A.), Nottingham Biomedical Research Centre, Nottingham, UK.
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D.P. Auer
fSir Peter Mansfield Imaging Centre (R.A.D., D.P.A.), University of Nottingham, Nottingham, UK
gRadiological Sciences, (R.A.D., D.P.A.), Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK
hNational Institute for Health Research (R.A.D., D.P.A.), Nottingham Biomedical Research Centre, Nottingham, UK.
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    Fig 1.

    Examples of the MRS voxel placement in the PGM (A) and cerebellum (B) in two 7-year-old children. Corresponding OFF (C and D) and ON-OFF (E and F) spectra are shown below. Individual metabolite spectra fitted by LCModel are highlighted in different colors. D, The arrow highlights visible resonances that are particularly large in the cerebellum and likely belong to taurine and scyllo-inositol. Residuals of the fits (black, upper row) and estimated LCModel baselines (black, lower row) are shown for each spectrum.

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    Fig 2.

    Boxplots showing the water-scaled metabolite values in institutional units in the PGM and cerebellum.

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    Fig 3.

    Boxplots showing the metabolite ratios in the PGM and cerebellum.

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F. Raschke, R. Noeske, R.A Dineen, D.P. Auer
Measuring Cerebral and Cerebellar Glutathione in Children Using 1H MEGA-PRESS MRS
American Journal of Neuroradiology Dec 2017, DOI: 10.3174/ajnr.A5457

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Measuring Cerebral and Cerebellar Glutathione in Children Using 1H MEGA-PRESS MRS
F. Raschke, R. Noeske, R.A Dineen, D.P. Auer
American Journal of Neuroradiology Dec 2017, DOI: 10.3174/ajnr.A5457
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