Periventricular Location as a Risk Factor for Hemorrhage and Severe Clinical Presentation in Pediatric Patients with Untreated Brain Arteriovenous Malformations

From the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) and Neuroradiology (J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China; China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China; Center for Stroke (Y.-L.Z., J.-Z.Z.), Beijing Institute for Brain Disorders, Beijing, P. R. China; and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.

From the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) and Neuroradiology (J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China; China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China; Center for Stroke (Y.-L.Z., J.-Z.Z.), Beijing Institute for Brain Disorders, Beijing, P. R. China; and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.

From the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) and Neuroradiology (J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China; China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China; Center for Stroke (Y.-L.Z., J.-Z.Z.), Beijing Institute for Brain Disorders, Beijing, P. R. China; and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.

From the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) and Neuroradiology (J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China; China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China; Center for Stroke (Y.-L.Z., J.-Z.Z.), Beijing Institute for Brain Disorders, Beijing, P. R. China; and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.

From the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) and Neuroradiology (J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China; China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China; Center for Stroke (Y.-L.Z., J.-Z.Z.), Beijing Institute for Brain Disorders, Beijing, P. R. China; and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.

From the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) and Neuroradiology (J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China; China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China; Center for Stroke (Y.-L.Z., J.-Z.Z.), Beijing Institute for Brain Disorders, Beijing, P. R. China; and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.

From the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) and Neuroradiology (J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China; China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China; Center for Stroke (Y.-L.Z., J.-Z.Z.), Beijing Institute for Brain Disorders, Beijing, P. R. China; and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.

From the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) and Neuroradiology (J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China; China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China; Center for Stroke (Y.-L.Z., J.-Z.Z.), Beijing Institute for Brain Disorders, Beijing, P. R. China; and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.

From the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) and Neuroradiology (J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China; China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China; Center for Stroke (Y.-L.Z., J.-Z.Z.), Beijing Institute for Brain Disorders, Beijing, P. R. China; and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.

From the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) and Neuroradiology (J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China; China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China; Center for Stroke (Y.-L.Z., J.-Z.Z.), Beijing Institute for Brain Disorders, Beijing, P. R. China; and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.

From the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) and Neuroradiology (J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China; China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China; Center for Stroke (Y.-L.Z., J.-Z.Z.), Beijing Institute for Brain Disorders, Beijing, P. R. China; and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.

From the Departments of Neurosurgery (L.M., Z.H., X.-L.C., X.-J.L., H.W., X.Y., S.-L.W., Y.C., S.W., Y.-L.Z., J.-Z.Z.) and Neuroradiology (J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China; China National Clinical Research Center for Neurological Diseases (L.M., Z.H., X.-L.C., X.-J.L., Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China; Center for Stroke (Y.-L.Z., J.-Z.Z.), Beijing Institute for Brain Disorders, Beijing, P. R. China; and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease (Y.C., S.W., Y.-L.Z., J.-Z.Z.), Beijing, P. R. China.