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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Case of the Week

Section Editors: Matylda Machnowska1 and Anvita Pauranik2
1University of Toronto, Toronto, Ontario, Canada
2BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada

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Submit a Case Previous Cases ASPNR Pediatric Cases

July 6, 2015
  • Description
  • Legends
  • Diagnosis
  • Brain Teaser
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Bone Flap Osteomyelitis with Subperiosteal Abscess

  • Background: Patients who have undergone a craniotomy may present with infection at or near the incision site. The process may spread by proximity to the devascularized craniotomy bone flap, which may become an infected bone sequestrum. However, the superficial soft tissue swelling is not always present.
  • Clinical Presentation: Pain, fever, erethyma, headache, altered mental status, and rarely, a draining fistula
  • Key Diagnostic Features:
    • CT: Bone flap erosions of the outer and inner tables
    • MR: Loss of the normal high T1-weighted bone flap marrow signal, with adjacent dural thickening and subperiosteal and subgaleal enhancement in the overlying scalp. An epidural or subperiosteal collection may be seen, visible on postcontrast imaging, which is suggestive of an abscess.
  • DDx:
    • Aseptic flap necrosis
    • Bone flap tuberculosis
  • Treatment: Patient is placed on broad-spectrum antibiotics, which are subsequently tapered when a specific organism is isolated.
    • In this case, the microorganism was Serratia Marcescens. This patient had the devitalized bone flap removed with concurrent mesh cranioplasty.

Suggested Reading

Pandey AS, Surana A. Tuberculous osteomyelitis of the bone flap following craniotomy. Indian J Tuberc 2011;58:129–31

Wilson IF, Candia GJ, Worthington MG, et al. Chronic osteomyelitis due to corynebacteria in a postcraniotomy bone flap. Clin Infect Dis 1999;28:1323–24, 10.1086/517783

Levitt MR, Gabikian P, Pottinger P, et al. Propionibacterium acnes osteomyelitis occurring 23 years after craniotomy: case report and review of literature. Neurosurgery 2011;69:E773–79, 10.1227/NEU.0b013e31821964ba

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American Journal of Neuroradiology: 46 (6)
American Journal of Neuroradiology
Vol. 46, Issue 6
1 Jun 2025
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