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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Case of the Week

Section Editors: Matylda Machnowska1 and Anvita Pauranik2
1University of Toronto, Toronto, Ontario, Canada
2BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada

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May 21, 2020
  • Description
  • Legends
  • Diagnosis
  • Brain Teaser
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Intracranial Metal Emboli

  • Background:
    • The combination of clinical history (recent left heart valve repair) and multiple new spherical foci of T2* signal dephasing (larger ones with targetlike appearance) is highly characteristic of metal emboli.
    • This finding was more prevalent in the era of early-version detachable coils.
    • Incidence is difficult to estimate but is believed to be uncommon.
    • Apart from metal, periprocedural foreign body emboli can be seen in a variety of clinical settings.
  • Clinical Presentation:
    • Varies from asymptomatic (as in this case) to focal deficits, seizure, and headaches, depending on location and size of emboli and immune response
  • Key Diagnostic Features:
    • History of cardiac procedure (open or endovascular) or cerebrovascular catheterization (diagnostic or therapeutic) and multiple new, round ferromagnetic susceptibility foci, especially targetlike lesions, which are atypical for other entities
    • Tiny size and marked ferromagnetism may explain the lack of x-ray attenuation, therefore rendering these typically invisible on CT.
  • Differential Diagnoses:
    • There is no real differential diagnosis. The appearance can be misinterpreted as microbleeds, such as cavernous angiomas, amyloid, axonal injury, etc.
    • A perfectly round and targetlike appearance in the appropriate clinical context excludes the above physiologic processes from the differential diagnosis.
  • Treatment:
    • Usually noninvasive; symptom control

Suggested Reading

  1. Wingerchuk DM, Krecke KN, Fulgham JR. Multifocal brain MRI artifacts secondary to embolic metal fragments. Neurology 1997;49:1451–53
  2. Yasuda R, Maeda M, Umino M, et al. Suspected metallic embolism following endovascular treatment of intracranial aneurysms. AJNR Am J Neuroradiol 2016;37:1696–99

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American Journal of Neuroradiology: 46 (6)
American Journal of Neuroradiology
Vol. 46, Issue 6
1 Jun 2025
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