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Case of the Week

Section Editors: Matylda Machnowska1 and Anvita Pauranik2
1University of Toronto, Toronto, Ontario, Canada
2BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada

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March 30, 2015
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Heat Stroke

  • Heat stroke involves core body temperature elevation, in the absence of fever, above 40o C, 2o to environmental exposure with or without increased physical exertion.
  • The patient’s rectal temperature upon presentation was 42o C (108o F). He was unconscious and in respiratory distress. MRI was obtained 5 days after the event.
  • Key Diagnostic Features: Hyperthermia is usually a known diagnosis at the time of imaging. Imaging findings have been reported as bilaterally symmetric with greatest involvement in the cerebellum. Restricted diffusion has been reported in the cerebellar hemispheres, caudate nuclei, and hippocampi with corresponding increased T2 signal. Involvement of the splenium of the corpus callosum has also been described. Cerebellar atrophy is common in the chronic phase.
  • DDx: Metabolic or toxic injury
  • Rx: Rapid cooling to restore core body temperature to normal, including evaporation techniques; peritoneal, thoracic, rectal, and gastric lavage with ice water; cold intravenous fluids; cold humidified oxygen; cooling blankets; and wet towels.

Suggested Reading

Mahajan S, Schucany WG. Symmetric bilateral caudate, hippocampal, cerebellar, and subcortical white matter MRI abnormalities in an adult patient with heat stroke. Proc (Bayl Univ Med Cent) 2008;21:433–36

McLaughlin CT, Kane AG, Auber AE. MR imaging of heat stroke: external capsule and thalamic T1 shortening and cerebellar injury. AJNR Am J Neuroradiol 2003;24:1372–75

Lee JS, Choi JC, Kang S-Y, et al. Heat stroke: increased signal intensity in the bilateral cerebellar dentate nuclei and splenium on diffusion-weighted MR imaging. AJNR Am J Neuroradiol 2009;30:e58

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American Journal of Neuroradiology: 46 (6)
American Journal of Neuroradiology
Vol. 46, Issue 6
1 Jun 2025
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