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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Case of the Week

Section Editors: Matylda Machnowska1 and Anvita Pauranik2
1University of Toronto, Toronto, Ontario, Canada
2BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada

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January 24, 2019
  • Description
  • Legends
  • Diagnosis
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LENTICULOSTRIATE ARTERY DISSECTING ANEURYSM

  • Background
    • ​Aneurysms arising along the lenticulostriate artery (LSA) are rare, but thought to be a cause of ischemic or hemorrhagic stroke.
    • The majority of these aneurysms are likely to be dissecting aneurysms. 
    • In histopathological examination of surgical specimens, the lack of internal elastic lamina is a significant feature.
    • Because of the small size of aneurysms and the parent vessels, non-invasive studies may be normal or initially read as normal.
  • Clinical Presentation
    • ​LSA dissection may result in lacunar infarction and/or basal ganglia hemorrhage depending on whether it results in luminal occlusion or arterial rupture respectively.
    • Even though ruptured LSA aneurysms have a high rebleeding risk they can heal spontaneously.
  • Key Diagnostic Features
    • ​Repeated examinations with multiple modalities are considered necessary. Catheter angiography is the gold standard for detection, characterization and follow-up.
    • In addition, features of synchronic or metachronic infarction and hemorrhage could be more suggestive for dissection.
  • Differential Diagnosis
    • ​Moyamoya disease: Steno-occlusive disease in distal ICA, which evolves with LSA hypertrophy (puff of smoke sign). They can develop small aneurysms along the hypertrophied arteries. 
    • Arteriovenous malformation: Has enlarged feeding arteries, nidus, and draining veins. 
    • Systemic vasculitis: Rarely can cause penetrating artery aneurysms, and are usually associated with an autoimmune disease.
    • Mycotic aneurysms: Usually patients with infective endocarditis, and are more common in distal cortical branches, rather than perforating vessels.
  • Treatment
    • ​Conservative treatment with close follow-up examinations and strict blood pressure control could be an effective treatment. 
    • For rupture cases, surgery with clipping or resection of aneurysms and endovascular intervention with parent vessel occlusion can be considered.
    • The management of LSA dissecting aneurysms remains controversial, due to uncertainty of its natural history and the risk associated with endovascular or surgical treatment. A multi-disciplinary team is needed for therapeutic strategies in a case-by-case basis.

Suggested Reading

  1. Mizutani T, Kojima H, Miki Y. Arterial dissections of penetrating cerebral arteries causing hypertension-induced cerebral hemorrhage. J Neurosurg 2000; 93:859-62, 10.3171/jns.2000.93.5.0859.
  2. Heck O, Anxionnat R, Lacour JC. Rupture of lenticulostriate artery aneurysms. J Neurosurg 2014; 120:426-33, 10.3171/2013.8.JNS13608.
  3. Lama S, Dolati P, Sutherland GR. Controversy in the management of lenticulostriate artery dissecting aneurysm: a case report and review of the literature. World Neurosurg 2014; 81:441.e1-7, 10.1016/j.wneu.2012.12.006.

Current Issue

American Journal of Neuroradiology: 46 (6)
American Journal of Neuroradiology
Vol. 46, Issue 6
1 Jun 2025
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