More articles from ULTRA-HIGH-FIELD MRI/IMAGING OF EPILEPSY/DEMYELINATING DISEASES/INFLAMMATION/INFECTION
- Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes
Lesion phenotype (ie, different levels of axonal and myelin loss and spatial distribution) was characterized using quantitative susceptibility mapping, susceptibility-weighted imaging, T1-relaxometry, myelin mapping, and diffusion MRI. A more severe disease course was observed in hyperintense and paramagnetic rim lesions in the periventricular white matter.
- Comparison of a Whole-Brain Contrast-Enhanced 3D TSE T1WI versus Orbits Contrast-Enhanced 2D Coronal T1WI at 3T MRI for the Detection of Optic Nerve Enhancement in Patients with Acute Loss of Visual Acuity
This retrospective, single-center study of 1023 patients presenting with acute loss of vision compared orbits contrast-enhanced 2D coronal T1WI with a whole-brain contrast-enhanced 3D TSE T1WI at 3T for the detection of optic nerve enhancement. The latter (WBCE-3D T1WI) demonstrated higher sensitivity and specificity in diagnosing optic neuritis, particularly in cases involving the canalicular segments.
- Central Vein Sign in Multiple Sclerosis: A Comparison Study of the Diagnostic Performance of 3T versus 7T MRI
The perivenular relationship of MS demyelinating plaque is thought to represent one of the most histologically specific features of MS. In this retrospective study, the authors directly compared the utility of 3T SWI, 7T SWI, and T2&WI in detecting central vein sign (CVS) and the ability of CVS to differentiate MS from nonspecific WM lesions in patients without MS (presumed vascular origin) in a large cohort of patients. They found that 7T SWI and T2* (73% and 87% of lesions, respectively) showed significantly more CVSs than 3T (31%). Both T2*WI and 7T SWI sequences were 100% accurate (AUC=1.0) for diagnosing MS from WM lesions of presumed vascular origin, which was superior to 3T (AUC=0.975).