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Research ArticleNeurovascular/Stroke Imaging

Decreased Visibility of Deep Medullary Vein Associated with Cerebral Small Vessel Disease Burden through Increased Interstitial Fluid in White Matter

Zhihua Xu, Haiyuan Lan, Xinjun Lei, Hongxia Zhang, Fanfan Xiong and Lebing Wang
American Journal of Neuroradiology June 2025, 46 (6) 1112-1119; DOI: https://doi.org/10.3174/ajnr.A8632
Zhihua Xu
aFrom the Department of Radiology (Z.X., H.Z., F.X.), Tongde Hospital of Zhejiang Province, Hangzhou, China
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Haiyuan Lan
bDepartment of Radiology (H.L., X.L., L.W.), Lishui Hospital of Traditional Chinese Medicine, affiliated with Zhejiang Chinese Medical University, Lishui, China.
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Xinjun Lei
bDepartment of Radiology (H.L., X.L., L.W.), Lishui Hospital of Traditional Chinese Medicine, affiliated with Zhejiang Chinese Medical University, Lishui, China.
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Hongxia Zhang
aFrom the Department of Radiology (Z.X., H.Z., F.X.), Tongde Hospital of Zhejiang Province, Hangzhou, China
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Fanfan Xiong
aFrom the Department of Radiology (Z.X., H.Z., F.X.), Tongde Hospital of Zhejiang Province, Hangzhou, China
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Lebing Wang
bDepartment of Radiology (H.L., X.L., L.W.), Lishui Hospital of Traditional Chinese Medicine, affiliated with Zhejiang Chinese Medical University, Lishui, China.
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References

  1. 1.↵
    1. Duering M,
    2. Biessels GJ,
    3. Brodtmann A, et al
    . Neuroimaging standards for research into small vessel disease—advances since 2013. Lancet Neurol 2023;22:602–18 pmid:37236211
    CrossRefPubMed
  2. 2.↵
    1. Chen X,
    2. Wei L,
    3. Wang J, et al
    . Decreased visible deep medullary veins is a novel imaging marker for cerebral small vessel disease. Neurol Sci 2020;41:1497–506 doi:10.1007/s10072-019-04203-9 pmid:31955350
    CrossRefPubMed
  3. 3.↵
    1. Xu Z,
    2. Li F,
    3. Wand B, et al
    . New insights in addressing cerebral small vessel disease: association with the deep medullary veins. Front Aging Neurosci 2020;12:597799
    CrossRefPubMed
  4. 4.↵
    1. Ao D-H,
    2. Zhang D-D,
    3. Zhai F-F, et al
    . Brain deep medullary veins on 3-T MRI in a population-based cohort. J Cereb Blood Flow Metab 2021;41:561–68 doi:10.1177/0271678X20918467 pmid:32312169
    CrossRefPubMed
  5. 5.↵
    1. Fulop GA,
    2. Tarantini S,
    3. Yabluchanskiy A, et al
    . Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment. Am J Physiol Heart Circ Physiol 2019;316:H1124–140 doi:10.1152/ajpheart.00776.2018 pmid:30848677
    CrossRefPubMed
  6. 6.↵
    1. Taoka T,
    2. Fukusumi A,
    3. Miyasaka T, et al
    . Structure of the medullary veins of the cerebral hemisphere and related disorders. Radiographics 2017;37:281–97 doi:10.1148/rg.2017160061 pmid:28076020
    CrossRefPubMed
  7. 7.↵
    1. Zhang R,
    2. Huang P,
    3. Jiaerken Y, et al
    . Venous disruption affects white matter integrity through increased interstitial fluid in cerebral small vessel disease. J Cereb Blood Flow Metab 2021;41:157–65 doi:10.1177/0271678X20904840 pmid:32065078
    CrossRefPubMed
  8. 8.↵
    1. Lan H,
    2. Lei X,
    3. Xu Z, et al
    . New insights in addressing cerebral small vessel disease: associated with extracellular fluid in white matter. Front Neurosci 2022;16:1042824 doi:10.3389/fnins.2022.1042824 pmid:36340793
    CrossRefPubMed
  9. 9.↵
    1. Huang P,
    2. Zhang R,
    3. Jiaerken Y, et al
    . White matter free water is a composite marker of cerebral small vessel degeneration. Transl Stroke Res 2022;13:56–64 doi:10.1007/s12975-021-00899-0 pmid:33634379
    CrossRefPubMed
  10. 10.↵
    1. Zhang K,
    2. Zhou Y,
    3. Zhang W, et al
    . MRI-visible perivascular spaces in basal ganglia but not centrum semiovale or hippocampus were related to deep medullary veins changes. J Cereb Blood Flow Metab 2022;42:136–44 doi:10.1177/0271678X211038138 pmid:34431378
    CrossRefPubMed
  11. 11.↵
    1. Wardlaw JM,
    2. Smith EE,
    3. Biessels GJ
    ; STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1), et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 2013;12:822–38 doi:10.1016/S1474-4422(13)70124-8 pmid:23867200
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Kim KW,
    2. MacFall JR,
    3. Payne ME
    . Classification of white matter lesions on magnetic resonance imaging in elderly persons. Biol Psychiatry 2008;64:273–80 doi:10.1016/j.biopsych.2008.03.024 pmid:18471801
    CrossRefPubMed
  13. 13.↵
    1. Griffanti L,
    2. Zamboni G,
    3. Khan A, et al
    . BIANCA (Brain Intensity AbNormality Classification Algorithm): a new tool for automated segmentation of white matter hyperintensities. Neuroimage 2016;141:191–205 doi:10.1016/j.neuroimage.2016.07.018 pmid:27402600
    CrossRefPubMed
  14. 14.↵
    1. Staals J,
    2. Makin SDJ,
    3. Doubal FN, et al
    . Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden. Neurology 2014;83:1228–34 doi:10.1212/WNL.0000000000000837 pmid:25165388
    Abstract/FREE Full Text
  15. 15.↵
    1. Lee C,
    2. Pennington MA,
    3. Kenney CM
    . MR evaluation of developmental venous anomalies: medullary venous anatomy of venous angiomas. AJNR Am J Neuroradiol 1996;17:61–70 pmid:8770251
    PubMedWeb of Science
  16. 16.↵
    1. Zhang R,
    2. Zhou Y,
    3. Yan S, et al
    . A brain region-based deep medullary veins visual score on susceptibility weighted imaging. Front Aging Neurosci 2017;9:269 doi:10.3389/fnagi.2017.00269 pmid:28848426
    CrossRefPubMed
  17. 17.↵
    1. Liu Z-Y,
    2. Zhai F-F,
    3. Ao D-H, et al
    . Deep medullary veins are associated with widespread brain structural abnormalities. J Cereb Blood Flow Metab 2022;42:997–1006 doi:10.1177/0271678X211065210 pmid:34855528
    CrossRefPubMed
  18. 18.↵
    1. Pasternak O,
    2. Sochen N,
    3. Gur Y, et al
    . Free water elimination and mapping from diffusion MRI. Magn Reson Med 2009;62:717–30 doi:10.1002/mrm.22055 pmid:19623619
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Hoy AR,
    2. Koay CG,
    3. Kecskemeti SR, et al
    . Optimization of a free water elimination two-compartment model for diffusion tensor imaging. Neuroimage 2014;103:323–33 doi:10.1016/j.neuroimage.2014.09.053 pmid:25271843
    CrossRefPubMed
  20. 20.↵
    1. Lahna D,
    2. Schwartz DL,
    3. Woltjer R, et al
    . Venous collagenosis as pathogenesis of white matter hyperintensity. Ann Neurol 2022;92:992–1000 pmid:36054513
    CrossRefPubMed
  21. 21.↵
    1. Zhou Y,
    2. Li Q,
    3. Zhang R, et al
    . Role of deep medullary veins in pathogenesis of lacunes: longitudinal observations from the CIRCLE study. J Cereb Blood Flow Metab 2020;40:1797–805 doi:10.1177/0271678X19882918 pmid:31619117
    CrossRefPubMed
  22. 22.↵
    1. Xu Z,
    2. Tong Z,
    3. Duan Y, et al
    . Diffusion- and susceptibility weighted imaging mismatch correlates with collateral circulation and prognosis after middle cerebral artery M1-segment occlusion. Front Neurol 2021;12:660529 doi:10.3389/fneur.2021.660529 pmid:34381410
    CrossRefPubMed
  23. 23.↵
    1. Keith J,
    2. Gao F-Q,
    3. Noor R, et al
    . Collagenosis of the deep medullary veins: an underrecognized pathologic correlate of white matter hyperintensities and periventricular infarction? J Neuropathol Exp Neurol 2017;76:299–312 doi:10.1093/jnen/nlx009 pmid:28431180
    CrossRefPubMed
  24. 24.↵
    1. Beggs CB
    . Venous hemodynamics in neurological disorders: an analytical review with hydrodynamic analysis. BMC Med 2013;11:142 doi:10.1186/1741-7015-11-142 pmid:23724917
    CrossRefPubMed
  25. 25.↵
    1. Haacke EM,
    2. Ge Y,
    3. Sethi SK, et al
    . An overview of venous abnormalities related to the development of lesions in multiple sclerosis. Front Neurol 2021;12:561458doi:10.3389/fneur.2021.561458 pmid:33981281
    CrossRefPubMed
  26. 26.↵
    1. Kanekar SG,
    2. Zacharia T,
    3. Roller R
    . Imaging of stroke: part 2, pathophysiology at the molecular and cellular levels and corresponding imaging changes. AJR Am J Roentgenol 2012;198:63–74 doi:10.2214/AJR.10.7312 pmid:22194480
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Doron O,
    2. Or T,
    3. Battino L, et al
    . Cerebral blood flow augmentation using a cardiac-gated intracranial pulsating balloon pump in a swine model of elevated ICP. J Neurosurg 2020;132:1606–15 doi:10.3171/2019.1.JNS182864 pmid:30978692
    CrossRefPubMed
  28. 28.↵
    1. Pescatore LA,
    2. Gamarra LF,
    3. Liberman M
    . Multifaceted mechanisms of vascular calcification in aging. Arterioscler Thromb Vasc Biol 2019;39:1307–16 doi:10.1161/ATVBAHA.118.311576 pmid:31144990
    CrossRefPubMed
  29. 29.↵
    1. Pierce GL,
    2. Coutinho TA,
    3. DuBose LE, et al
    . Is it good to have a stiff aorta with aging? Causes and consequences. Physiology (Bethesda) 2022;37:154–73 doi:10.1152/physiol.00035.2021 pmid:34779281
    CrossRefPubMed
  30. 30.↵
    1. Cannistraro RJ,
    2. Badi M,
    3. Eidelman BH, et al
    . CNS small vessel disease: a clinical review. Neurology 2019;92:1146–56 doi:10.1212/WNL.0000000000007654 pmid:31142635
    Abstract/FREE Full Text
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Zhihua Xu, Haiyuan Lan, Xinjun Lei, Hongxia Zhang, Fanfan Xiong, Lebing Wang
Decreased Visibility of Deep Medullary Vein Associated with Cerebral Small Vessel Disease Burden through Increased Interstitial Fluid in White Matter
American Journal of Neuroradiology Jun 2025, 46 (6) 1112-1119; DOI: 10.3174/ajnr.A8632

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DMV, IFS and CSVD burden
Zhihua Xu, Haiyuan Lan, Xinjun Lei, Hongxia Zhang, Fanfan Xiong, Lebing Wang
American Journal of Neuroradiology Jun 2025, 46 (6) 1112-1119; DOI: 10.3174/ajnr.A8632
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