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This study uses simultaneous PET/MRI, which integrates structural connectivity, functional connectivity, and glucose metabolism in IGE to elucidate abnormalities of the neocortex and to analyze the correlations between these abnormalities and clinical presentations. The results show dissociated patterns of abnormalities: structural connectivity abnormalities in the limbic and visual networks, functional connectivity deficits in the default mode network, and metabolic reductions in the frontoparietal and somatomotor networks.