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Research ArticleUltra-High-Field MRI/Imaging of Epilepsy/Demyelinating Diseases/Inflammation/Infection

Multicenter Automated Central Vein Sign Detection Performs as Well as Manual Assessment for the Diagnosis of Multiple Sclerosis

A.R. Manning, V. Letchuman, M.L. Martin, E. Gombos, T. Robert-Fitzgerald, Q. Cao, P. Raza, C.M. O’Donnell, B. Renner, L. Daboul, P. Rodrigues, M. Ramos, J. Derbyshire, C. Azevedo, A. Bar-Or, E. Caverzasi, P.A. Calabresi, B.A.C. Cree, L. Freeman, R.G. Henry, E.E. Longbrake, J. Oh, N. Papinutto, D. Pelletier, R.D. Samudralwar, S. Suthiphosuwan, M.K. Schindler, M. Bilello, J.W. Song, E.S. Sotirchos, N.L. Sicotte, O. Al-Louzi, A.J. Solomon, D.S. Reich, D. Ontaneda, P. Sati, R.T. Shinohara and the NAIMS Cooperative
American Journal of Neuroradiology March 2025, 46 (3) 620-626; DOI: https://doi.org/10.3174/ajnr.A8510
A.R. Manning
aFrom the Penn Statistics in Imaging and Visualization Center (A.R.M., M.L.M., T.R.-F., Q.C., C.M.O., R.T.S.), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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  • ORCID record for A.R. Manning
V. Letchuman
bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
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M.L. Martin
aFrom the Penn Statistics in Imaging and Visualization Center (A.R.M., M.L.M., T.R.-F., Q.C., C.M.O., R.T.S.), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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  • ORCID record for M.L. Martin
E. Gombos
cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California
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  • ORCID record for E. Gombos
T. Robert-Fitzgerald
aFrom the Penn Statistics in Imaging and Visualization Center (A.R.M., M.L.M., T.R.-F., Q.C., C.M.O., R.T.S.), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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Q. Cao
aFrom the Penn Statistics in Imaging and Visualization Center (A.R.M., M.L.M., T.R.-F., Q.C., C.M.O., R.T.S.), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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P. Raza
dCleveland Clinic Lerner College of Medicine (P. Raza, L.D.), Cleveland, Ohio
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  • ORCID record for P. Raza
C.M. O’Donnell
aFrom the Penn Statistics in Imaging and Visualization Center (A.R.M., M.L.M., T.R.-F., Q.C., C.M.O., R.T.S.), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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B. Renner
cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California
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L. Daboul
bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
dCleveland Clinic Lerner College of Medicine (P. Raza, L.D.), Cleveland, Ohio
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P. Rodrigues
eQMENTA Inc. (P. Rodrigues, M.R.), Boston, Massachusetts
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M. Ramos
eQMENTA Inc. (P. Rodrigues, M.R.), Boston, Massachusetts
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J. Derbyshire
fSection on Functional Imaging Methods (J.D.), Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
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C. Azevedo
gDepartment of Neurology (C.A., D.P.), University of Southern California, Los Angeles, California
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A. Bar-Or
hDepartment of Neurology (A.B.-O., R.D.S., M.K.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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E. Caverzasi
i UCSF Weill Institute for Neurosciences (E.C., B.A.C.C., R.G.H., N.P.), Department of Neurology, University of California San Francisco, San Francisco, California
jDepartment of Brain and Behavioral Sciences (E.C.), University of Pavia, Pavia, Italy; Neuroradiology Department, Advanced Imaging and Radiomics Center (E.C.), IRCCS Mondino Foundation, Pavia, Italy
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P.A. Calabresi
kDepartment of Neurology (P.A.C., E.S.S.), Johns Hopkins University, Baltimore, Maryland
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  • ORCID record for P.A. Calabresi
B.A.C. Cree
i UCSF Weill Institute for Neurosciences (E.C., B.A.C.C., R.G.H., N.P.), Department of Neurology, University of California San Francisco, San Francisco, California
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L. Freeman
lDepartment of Neurology, Dell Medical School (L.F.), The University of Texas at Austin, Austin, Texas
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R.G. Henry
i UCSF Weill Institute for Neurosciences (E.C., B.A.C.C., R.G.H., N.P.), Department of Neurology, University of California San Francisco, San Francisco, California
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E.E. Longbrake
mDepartment of Neurology (E.E.L.), Yale University, New Haven, Connecticut
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J. Oh
nDivision of Neurology (J.O.), Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto, Canada
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N. Papinutto
i UCSF Weill Institute for Neurosciences (E.C., B.A.C.C., R.G.H., N.P.), Department of Neurology, University of California San Francisco, San Francisco, California
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D. Pelletier
gDepartment of Neurology (C.A., D.P.), University of Southern California, Los Angeles, California
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R.D. Samudralwar
hDepartment of Neurology (A.B.-O., R.D.S., M.K.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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S. Suthiphosuwan
oDepartment of Medical Imaging (S.S.), St. Michael’s Hospital, University of Toronto, Toronto, Canada
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M.K. Schindler
hDepartment of Neurology (A.B.-O., R.D.S., M.K.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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M. Bilello
pDepartment of Radiology (M.B., J.W.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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J.W. Song
pDepartment of Radiology (M.B., J.W.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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E.S. Sotirchos
kDepartment of Neurology (P.A.C., E.S.S.), Johns Hopkins University, Baltimore, Maryland
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N.L. Sicotte
cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California
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O. Al-Louzi
bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California
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A.J. Solomon
qDepartment of Neurological Sciences (A.J.S.), Larner College of Medicine at the University of Vermont, Burlington, Vermont
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D.S. Reich
bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
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D. Ontaneda
rMellen Center for Multiple Sclerosis (D.O.), Cleveland Clinic, Cleveland, Ohio
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P. Sati
bTranslational Neuroradiology Section (V.L., L.D., O.A.-L., D.S.R., P.S.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
cDepartment of Neurology (E.G., B.R., N.L.S., O.A.-L., P.S.), Cedars-Sinai Medical Center, Los Angeles, California
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R.T. Shinohara
aFrom the Penn Statistics in Imaging and Visualization Center (A.R.M., M.L.M., T.R.-F., Q.C., C.M.O., R.T.S.), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
sCenter for Biomedical Image Computing and Analytics (R.T.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
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American Journal of Neuroradiology: 46 (3)
American Journal of Neuroradiology
Vol. 46, Issue 3
1 Mar 2025
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A.R. Manning, V. Letchuman, M.L. Martin, E. Gombos, T. Robert-Fitzgerald, Q. Cao, P. Raza, C.M. O’Donnell, B. Renner, L. Daboul, P. Rodrigues, M. Ramos, J. Derbyshire, C. Azevedo, A. Bar-Or, E. Caverzasi, P.A. Calabresi, B.A.C. Cree, L. Freeman, R.G. Henry, E.E. Longbrake, J. Oh, N. Papinutto, D. Pelletier, R.D. Samudralwar, S. Suthiphosuwan, M.K. Schindler, M. Bilello, J.W. Song, E.S. Sotirchos, N.L. Sicotte, O. Al-Louzi, A.J. Solomon, D.S. Reich, D. Ontaneda, P. Sati, R.T. Shinohara, the NAIMS Cooperative
Multicenter Automated Central Vein Sign Detection Performs as Well as Manual Assessment for the Diagnosis of Multiple Sclerosis
American Journal of Neuroradiology Mar 2025, 46 (3) 620-626; DOI: 10.3174/ajnr.A8510

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Automated vs Manual Central Vein Sign in MS
A.R. Manning, V. Letchuman, M.L. Martin, E. Gombos, T. Robert-Fitzgerald, Q. Cao, P. Raza, C.M. O’Donnell, B. Renner, L. Daboul, P. Rodrigues, M. Ramos, J. Derbyshire, C. Azevedo, A. Bar-Or, E. Caverzasi, P.A. Calabresi, B.A.C. Cree, L. Freeman, R.G. Henry, E.E. Longbrake, J. Oh, N. Papinutto, D. Pelletier, R.D. Samudralwar, S. Suthiphosuwan, M.K. Schindler, M. Bilello, J.W. Song, E.S. Sotirchos, N.L. Sicotte, O. Al-Louzi, A.J. Solomon, D.S. Reich, D. Ontaneda, P. Sati, R.T. Shinohara, the NAIMS Cooperative
American Journal of Neuroradiology Mar 2025, 46 (3) 620-626; DOI: 10.3174/ajnr.A8510
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