Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Getting new auth cookie, if you see this message a lot, tell someone!
Research ArticleNeurovascular/Stroke Imaging

Assessment of Attenuation in Pericarotid Fat among Patients with Carotid Plaque and Spontaneous Carotid Dissection

Mohammed O. Alalfi, Riccardo Cau, Giovanni Maria Argiolas, Roberta Scicolone, Cesare Mantini, Valentina Nardi, John C. Benson, Jasjit S. Suri, Zafer Keser, Amir Lerman, Giuseppe Lanzino, Paolo Siotto and Luca Saba
American Journal of Neuroradiology February 2025, 46 (2) 259-264; DOI: https://doi.org/10.3174/ajnr.A8546
Mohammed O. Alalfi
aFrom the School of Medicine and Surger (M.O.A.), University of Bologna, Bologna, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Riccardo Cau
bDepartment of Radiology (R.C., R.S., L.S.), University of Cagliari, Cagliari, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Riccardo Cau
Giovanni Maria Argiolas
cDepartment of Radiology (G.M.A., P.S.), Azienda Ospedaliera Brotzu, Cagliari, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Roberta Scicolone
bDepartment of Radiology (R.C., R.S., L.S.), University of Cagliari, Cagliari, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Roberta Scicolone
Cesare Mantini
dDepartment of Neuroscience, Imaging and Clinical Sciences (C.M.), ‘G. d’Annunzio’ University of Chieti-Pescara, Chieti, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Valentina Nardi
eDepartment of Cardiovascular Medicine (V.N., A.L.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Valentina Nardi
John C. Benson
fDepartment of Radiology (J.C.B.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for John C. Benson
Jasjit S. Suri
gStroke Monitoring and Diagnostic Division (J.S.S.), AtheroPoint LLC, Roseville, California
jDepartment of ECE (J.S.S.), Idaho State University, Pocatello, Idaho
kGraphics Era University (J.S.S.), Dehradun, India
lUniversity Center for Research and Development (J.S.S.), Chandigarh University, Mohali, India
mSymbiosis Institute of Technology (J.S.S.), Nagpur Campus, Symbiosis International, Pune, India
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jasjit S. Suri
Zafer Keser
hDepartment of Neurology (Z.K.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Zafer Keser
Amir Lerman
eDepartment of Cardiovascular Medicine (V.N., A.L.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Giuseppe Lanzino
iDepartment of Neurologic Surgery (G.L.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Giuseppe Lanzino
Paolo Siotto
cDepartment of Radiology (G.M.A., P.S.), Azienda Ospedaliera Brotzu, Cagliari, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Luca Saba
bDepartment of Radiology (R.C., R.S., L.S.), University of Cagliari, Cagliari, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Luca Saba
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Baradaran H,
    2. Myneni PK,
    3. Patel P, et al
    . Association between carotid artery perivascular fat density and cerebrovascular ischemic events. J Am Heart Assoc 2018;7:e010383 doi:10.1161/JAHA.118.010383 pmid:30561272
    CrossRefPubMed
  2. 2.↵
    1. Saba L,
    2. Zucca S,
    3. Gupta A, et al
    . Perivascular fat density and contrast plaque enhancement: does a correlation exist? AJNR Am J Neuroradiol 2020;41:1460–65 doi:10.3174/ajnr.A6710 pmid:32732275
    Abstract/FREE Full Text
  3. 3.↵
    1. Zhang S,
    2. Gu H,
    3. Yu X, et al
    . Association between carotid artery perivascular fat density and intraplaque hemorrhage. Front Cardiovasc Med 2021;8:735794 doi:10.3389/fcvm.2021.735794 pmid:34616788
    CrossRefPubMed
  4. 4.↵
    1. Yu M,
    2. Meng Y,
    3. Zhang H, et al
    . Associations between pericarotid fat density and image-based risk characteristics of carotid plaque. Eur J Radiol 2022;153:110364 doi:10.1016/j.ejrad.2022.110364 pmid:35609448
    CrossRefPubMed
  5. 5.↵
    1. Cheng K,
    2. Lin A,
    3. Stecher X, et al
    . Association between spontaneous internal carotid artery dissection and perivascular adipose tissue attenuation on computed tomography angiography. Int J Stroke 2023;18:829–38 doi:10.1177/17474930231158538 pmid:36748981
    CrossRefPubMed
  6. 6.↵
    1. Saba L,
    2. Saam T,
    3. Jäger HR, et al
    . Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implications. Lancet Neurol 2019;18:559–72 doi:10.1016/S1474-4422(19)30035-3 pmid:30954372
    CrossRefPubMed
  7. 7.↵
    1. Libby P
    . Inflammation during the life cycle of the atherosclerotic plaque. Cardiovasc Res 2021;117:2525–36 doi:10.1093/cvr/cvab303 pmid:34550337
    CrossRefPubMed
  8. 8.↵
    1. Saba L,
    2. Cau R,
    3. Murgia A, et al
    . Carotid Plaque-RADS: a novel stroke risk classification system. JACC Cardiovasc Imaging 2024;17:62–75 doi:10.1016/j.jcmg.2023.09.005 pmid:37823860
    CrossRefPubMed
  9. 9.↵
    1. Saba L,
    2. Francone M,
    3. Bassareo PP, et al
    . CT attenuation analysis of carotid intraplaque hemorrhage. AJNR Am J Neuroradiol 2018;39:131–37 doi:10.3174/ajnr.A5461 pmid:29191874
    Abstract/FREE Full Text
  10. 10.↵
    1. Saba L,
    2. Mallarin G
    . Window settings for the study of calcified carotid plaques with multidetector CT angiography. AJNR Am J Neuroradiol 2009;30:1445–50 doi:10.3174/ajnr.A1509 pmid:19299487
    Abstract/FREE Full Text
  11. 11.↵
    1. Saba L,
    2. Mallarini G
    . Carotid plaque enhancement and symptom correlations: an evaluation by using multidetector row CT angiography. AJNR Am J Neuroradiol 2011;32:1919–25 doi:10.3174/ajnr.A2605 pmid:21868620
    Abstract/FREE Full Text
  12. 12.↵
    1. Antonopoulos AS,
    2. Sanna F,
    3. Sabharwal N, et al
    . Detecting human coronary inflammation by imaging perivascular fat. Sci Transl Med 2017;9:eaal2658 doi:10.1126/scitranslmed.aal2658 pmid:28701474
    Abstract/FREE Full Text
  13. 13.↵
    1. Yuvaraj J,
    2. Cheng K,
    3. Lin A, et al
    . The emerging role of CT-based imaging in adipose tissue and coronary inflammation. Cells 2021;10:1196 doi:10.3390/cells10051196 pmid:34068406
    CrossRefPubMed
  14. 14.↵
    1. Wall C,
    2. Huang Y,
    3. Le EPV, et al
    . Pericoronary and periaortic adipose tissue density are associated with inflammatory disease activity in Takayasu arteritis and atherosclerosis. Eur Heart J Open 2021;1:oeab019 doi:10.1093/ehjopen/oeab019 pmid:34661196
    CrossRefPubMed
  15. 15.↵
    1. Margaritis M,
    2. Antonopoulos AS,
    3. Digby J, et al
    . Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels. Circulation 2013;127:2209–21 doi:10.1161/CIRCULATIONAHA.112.001133 pmid:23625959
    Abstract/FREE Full Text
  16. 16.↵
    1. Debette S,
    2. Markus HS
    . The genetics of cervical artery dissection: a systematic review. Stroke 2009;40:e459–66 doi:10.1161/STROKEAHA.108.534669 pmid:19390073
    Abstract/FREE Full Text
  17. 17.↵
    1. Grau AJ,
    2. Brandt T,
    3. Buggle F, et al
    . Association of cervical artery dissection with recent infection. Arch Neurol 1999;56:851–56 doi:10.1001/archneur.56.7.851 pmid:10404987
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Keser Z,
    2. Chiang CC,
    3. Benson JC, et al
    . Cervical artery dissections: etiopathogenesis and management. Vasc Health Risk Manag 2022;18:685–700 doi:10.2147/VHRM.S362844 pmid:36082197
    CrossRefPubMed
  19. 19.↵
    1. Li H,
    2. Xu S,
    3. Xu B, et al
    . Unraveling the links between chronic inflammation, autoimmunity, and spontaneous cervicocranial arterial dissection. J Clin Med 2023;12:5132 doi:10.3390/jcm12155132 pmid:37568534
    CrossRefPubMed
  20. 20.↵
    1. Naggara O,
    2. Touzé E,
    3. Marsico R, et al
    . High-resolution MR imaging of periarterial edema associated with biological inflammation in spontaneous carotid dissection. Eur Radiology 2009;19:2255–60 doi:10.1007/s00330-009-1415-5 pmid:19396444
    CrossRefPubMed
  21. 21.↵
    1. Forster K,
    2. Poppert H,
    3. Conrad B, et al
    . Elevated inflammatory laboratory parameters in spontaneous cervical artery dissection as compared to traumatic dissection: a retrospective case-control study. J Neurol 2006;253:741–45 doi:10.1007/s00415-006-0109-z pmid:16502220
    CrossRefPubMed
  22. 22.↵
    1. Genius J,
    2. Dong-Si T,
    3. Grau AP, et al
    . Postacute C-reactive protein levels are elevated in cervical artery dissection. Stroke 2005;36:e42–44 doi:10.1161/01.STR.0000158911.74006.d6 pmid:15761204
    Abstract/FREE Full Text
  23. 23.↵
    1. Wolny RR,
    2. Kwieciński J,
    3. Zalewska J, et al
    . Pericoronary adipose tissue density is increased in patients with recent spontaneous coronary dissection. Heart 2023;109:1443–49 doi:10.1136/heartjnl-2023-322482 pmid:37316164
    Abstract/FREE Full Text
  24. 24.↵
    1. Pfefferkorn T,
    2. Saam T,
    3. Rominger A, et al
    . Vessel wall inflammation in spontaneous cervical artery dissection: a prospective, observational positron emission tomography, computed tomography, and magnetic resonance imaging study. Stroke 2011;42:1563–68 doi:10.1161/STROKEAHA.110.599548 pmid:21512185
    Abstract/FREE Full Text
  25. 25.↵
    1. Oikonomou EK,
    2. Marwan M,
    3. Desai MY, et al
    . Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data. Lancet 2018;392:929–39 doi:10.1016/S0140-6736(18)31114-0 pmid:30170852
    CrossRefPubMed
  26. 26.↵
    1. Mura M,
    2. Della Schiava N,
    3. Long A, et al
    . Carotid intraplaque haemorrhage: pathogenesis, histological classification, imaging methods and clinical value. Ann Transl Med 2020;8:1273 doi:10.21037/atm-20-1974 pmid:33178805
    CrossRefPubMed
  27. 27.↵
    1. Sakamoto A,
    2. Suwa K,
    3. Kawakami R, et al
    . Significance of intra-plaque hemorrhage for the development of high-risk vulnerable plaque: current understanding from basic to clinical points of view. Int J Mol Sci 2023;24:13298 doi:10.3390/ijms241713298 pmid:37686106
    CrossRefPubMed
  28. 28.↵
    1. Schindler A,
    2. Schinner R,
    3. Altaf N, et al
    . Prediction of stroke risk by detection of hemorrhage in carotid plaques: meta-analysis of individual patient data. JACC Cardiovasc Imaging 2020;13:395–406 doi:10.1016/j.jcmg.2019.03.028 pmid:31202755
    Abstract/FREE Full Text
  29. 29.↵
    1. Saba L,
    2. Micheletti G,
    3. Brinjikji W, et al
    . Carotid intraplaque-hemorrhage volume and its association with cerebrovascular events. AJNR Am J Neuroradiol 2019;40:1731–37 doi:10.3174/ajnr.A6189 pmid:31558503
    Abstract/FREE Full Text
  30. 30.↵
    1. Tu YB,
    2. Gu M,
    3. Zhou SQ, et al
    . Pericoronary adipose tissue attenuation in patients with acute aortic dissection based on coronary computed tomography angiography. Quant Imaging Med Surg 2024;14:31–42 doi:10.21037/qims-23-253 pmid:38223036
    CrossRefPubMed
  31. 31.↵
    1. Hedgire S,
    2. Baliyan V,
    3. Zucker EJ, et al
    . Perivascular epicardial fat stranding at coronary CT angiography: a marker of acute plaque rupture and spontaneous coronary artery dissection. Radiology 2018;287:808–15 doi:10.1148/radiol.2017171568 pmid:29401041
    CrossRefPubMed
  32. 32.↵
    1. Tan Z,
    2. Jin Q,
    3. Fan W, et al
    . Clinical implications of perivascular fat stranding surrounding spontaneous isolated superior mesenteric artery dissection on computed tomography. Exp Ther Med 2021;21:34 doi:10.3892/etm.2020.9466 pmid:33262820
    CrossRefPubMed
  33. 33.↵
    1. Bax M,
    2. Romanov V,
    3. Junday K, et al
    . Arterial dissections: common features and new perspectives. Front Cardiovasc Med 2022;9:1055862 doi:10.3389/fcvm.2022.1055862 pmid:36561772
    CrossRefPubMed
  34. 34.↵
    1. Haverich A,
    2. Boyle EC
    . Aortic dissection is a disease of the vasa vasorum. JTCVS Open 2021;5:30–32 doi:10.1016/j.xjon.2020.12.012 pmid:36003172
    CrossRefPubMed
  35. 35.↵
    1. Kim HW,
    2. Shi H,
    3. Winkler MA, et al
    . Perivascular adipose tissue and vascular perturbation/atherosclerosis. Arterioscler Thromb Vasc Biol 2020;40:2569–76 doi:10.1161/ATVBAHA.120.312470 pmid:32878476
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 46 (2)
American Journal of Neuroradiology
Vol. 46, Issue 2
1 Feb 2025
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Assessment of Attenuation in Pericarotid Fat among Patients with Carotid Plaque and Spontaneous Carotid Dissection
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Mohammed O. Alalfi, Riccardo Cau, Giovanni Maria Argiolas, Roberta Scicolone, Cesare Mantini, Valentina Nardi, John C. Benson, Jasjit S. Suri, Zafer Keser, Amir Lerman, Giuseppe Lanzino, Paolo Siotto, Luca Saba
Assessment of Attenuation in Pericarotid Fat among Patients with Carotid Plaque and Spontaneous Carotid Dissection
American Journal of Neuroradiology Feb 2025, 46 (2) 259-264; DOI: 10.3174/ajnr.A8546

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Peri-carotid Fat in Carotid Plaque & Dissection
Mohammed O. Alalfi, Riccardo Cau, Giovanni Maria Argiolas, Roberta Scicolone, Cesare Mantini, Valentina Nardi, John C. Benson, Jasjit S. Suri, Zafer Keser, Amir Lerman, Giuseppe Lanzino, Paolo Siotto, Luca Saba
American Journal of Neuroradiology Feb 2025, 46 (2) 259-264; DOI: 10.3174/ajnr.A8546
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Graphical Abstract
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • The insula and malignant cerebral edema
  • ICH Shape & Density Predict Rebleeding after MICE
  • Circle of Willis Variants and Stroke Outcomes
Show more Neurovascular/Stroke Imaging

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire