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Research ArticlePediatric Neuroimaging

Neuroradiologic, Clinical, and Genetic Characterization of Cerebellar Heterotopia: A Pediatric Multicentric Study

Ludovica Pasca, Filippo Arrigoni, Romina Romaniello, Maria Savina Severino, Davide Politano, Fulvio D’Abrusco, Jessica Garau, Valentina De Giorgis, Adriana Carpani, Sabrina Signorini, Simona Orcesi, Felice D’Arco, Enrico Alfei, Elisa Cattaneo, Elisa Rognone, Sara Uccella, Maria Teresa Divizia, Paolo Infantino, Enza Maria Valente, Renato Borgatti and Anna Pichiecchio
American Journal of Neuroradiology January 2025, 46 (1) 170-177; DOI: https://doi.org/10.3174/ajnr.A8450
Ludovica Pasca
aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy
bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy
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Filippo Arrigoni
cRadiology and Neuroradiology Department (F.A.), Vittore Buzzi Children’s Hospital, Milan, Italy
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Romina Romaniello
bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy
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Maria Savina Severino
dNeuroradiology Unit (M.S.S.), IRCCS Istituto Giannina Gaslini, Genova, Italy
lNeuroradiology Unit (M.S.S.), Child Neuropsychiatry Unit (S.U.), IRCCS Istituto Giannina Gaslini, Genoa, Italy
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Davide Politano
aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy
bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy
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Fulvio D’Abrusco
aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy
eDepartment of Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy
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Jessica Garau
fNeurogenetics Research Center (J.G., E.M.V.), IRCCS Mondino Foundation, Pavia, Italy
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Valentina De Giorgis
aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy
bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy
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Adriana Carpani
bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy
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Sabrina Signorini
bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy
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Simona Orcesi
aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy
bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy
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Felice D’Arco
gDepartment of Radiology (F.D.), Neuroradiology Unit, Great Ormond Street Hospital for Children, London, United Kingdom
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Enrico Alfei
hPediatric Neurology Unit (E.A.), and Department of Pediatrics, Vittore Buzzi Children’s Hospital, Milan, Italy
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Elisa Cattaneo
iClinical Genetics Unit (E.C.), Department of Pediatrics, Vittore Buzzi Children’s Hospital, Milan, Italy
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Elisa Rognone
jDepartment of Neuroradiology (E.R., A.P.), Advanced Imaging and Radiomics Center, IRCCS Mondino Foundation, Pavia, Italy
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Sara Uccella
kDepartment of Neurosciences (S.U.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy
lNeuroradiology Unit (M.S.S.), Child Neuropsychiatry Unit (S.U.), IRCCS Istituto Giannina Gaslini, Genoa, Italy
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Maria Teresa Divizia
mGenomics and Clinical Genetics Unit (M.T.D., P.I.), IRCCS Istituto Giannina Gaslini, Genoa, Italy
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Paolo Infantino
mGenomics and Clinical Genetics Unit (M.T.D., P.I.), IRCCS Istituto Giannina Gaslini, Genoa, Italy
nUniversità degli Studi di Genova (P.I.), Genoa, Italy
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Enza Maria Valente
aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy
eDepartment of Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy
fNeurogenetics Research Center (J.G., E.M.V.), IRCCS Mondino Foundation, Pavia, Italy
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Renato Borgatti
aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy
bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy
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Anna Pichiecchio
aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy
jDepartment of Neuroradiology (E.R., A.P.), Advanced Imaging and Radiomics Center, IRCCS Mondino Foundation, Pavia, Italy
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  • Article
  • Figures & Data
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Article Information

vol. 46 no. 1 170-177
DOI 
https://doi.org/10.3174/ajnr.A8450
PubMed 
39406511

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received March 26, 2024
  • Accepted after revision July 16, 2024
  • Published online January 8, 2025.

Article Versions

  • Latest version (October 15, 2024 - 09:54).
  • Latest version (December 27, 2024 - 07:32).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2025 by American Journal of Neuroradiology

Author Information

  1. Ludovica Pascaa,b,
  2. Filippo Arrigonic,
  3. Romina Romaniellob,
  4. Maria Savina Severinod,l,
  5. Davide Politanoa,b,
  6. Fulvio D’Abruscoa,e,
  7. Jessica Garauf,
  8. Valentina De Giorgisa,b,
  9. Adriana Carpanib,
  10. Sabrina Signorinib,
  11. Simona Orcesia,b,
  12. Felice D’Arcog,
  13. Enrico Alfeih,
  14. Elisa Cattaneoi,
  15. Elisa Rognonej,
  16. Sara Uccellak,l,
  17. Maria Teresa Diviziam,
  18. Paolo Infantinom,n,
  19. Enza Maria Valentea,e,f,
  20. Renato Borgattia,b and
  21. Anna Pichiecchioa,j
  1. aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy
  2. bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy
  3. cRadiology and Neuroradiology Department (F.A.), Vittore Buzzi Children’s Hospital, Milan, Italy
  4. dNeuroradiology Unit (M.S.S.), IRCCS Istituto Giannina Gaslini, Genova, Italy
  5. eDepartment of Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy
  6. fNeurogenetics Research Center (J.G., E.M.V.), IRCCS Mondino Foundation, Pavia, Italy
  7. gDepartment of Radiology (F.D.), Neuroradiology Unit, Great Ormond Street Hospital for Children, London, United Kingdom
  8. hPediatric Neurology Unit (E.A.), and Department of Pediatrics, Vittore Buzzi Children’s Hospital, Milan, Italy
  9. iClinical Genetics Unit (E.C.), Department of Pediatrics, Vittore Buzzi Children’s Hospital, Milan, Italy
  10. jDepartment of Neuroradiology (E.R., A.P.), Advanced Imaging and Radiomics Center, IRCCS Mondino Foundation, Pavia, Italy
  11. kDepartment of Neurosciences (S.U.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy
  12. lNeuroradiology Unit (M.S.S.), Child Neuropsychiatry Unit (S.U.), IRCCS Istituto Giannina Gaslini, Genoa, Italy
  13. mGenomics and Clinical Genetics Unit (M.T.D., P.I.), IRCCS Istituto Giannina Gaslini, Genoa, Italy
  14. nUniversità degli Studi di Genova (P.I.), Genoa, Italy
  1. Please address correspondence to Romina Romaniello, MD, Child Neurology and Psychiatry Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy; e-mail: romina.romaniello{at}mondino.it
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Ludovica Pasca, Filippo Arrigoni, Romina Romaniello, Maria Savina Severino, Davide Politano, Fulvio D’Abrusco, Jessica Garau, Valentina De Giorgis, Adriana Carpani, Sabrina Signorini, Simona Orcesi, Felice D’Arco, Enrico Alfei, Elisa Cattaneo, Elisa Rognone, Sara Uccella, Maria Teresa Divizia, Paolo Infantino, Enza Maria Valente, Renato Borgatti, Anna Pichiecchio
Neuroradiologic, Clinical, and Genetic Characterization of Cerebellar Heterotopia: A Pediatric Multicentric Study
American Journal of Neuroradiology Jan 2025, 46 (1) 170-177; DOI: 10.3174/ajnr.A8450

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Pediatric Cerebellar Heterotopia
Ludovica Pasca, Filippo Arrigoni, Romina Romaniello, Maria Savina Severino, Davide Politano, Fulvio D’Abrusco, Jessica Garau, Valentina De Giorgis, Adriana Carpani, Sabrina Signorini, Simona Orcesi, Felice D’Arco, Enrico Alfei, Elisa Cattaneo, Elisa Rognone, Sara Uccella, Maria Teresa Divizia, Paolo Infantino, Enza Maria Valente, Renato Borgatti, Anna Pichiecchio
American Journal of Neuroradiology Jan 2025, 46 (1) 170-177; DOI: 10.3174/ajnr.A8450
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