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Research ArticleBrain Tumor Imaging

Interrater Agreement of BT-RADS for Evaluation of Follow-up MRI in Patients with Treated Primary Brain Tumor

Michael Essien, Maxwell E. Cooper, Ashwani Gore, Taejin L. Min, Benjamin B. Risk, Gelareh Sadigh, Ranliang Hu, Michael J. Hoch and Brent D. Weinberg
American Journal of Neuroradiology September 2024, 45 (9) 1308-1315; DOI: https://doi.org/10.3174/ajnr.A8322
Michael Essien
aFrom the Department of Radiology and Imaging Sciences (M.E., M.E.C., A.G., T.L.M., R.H., B.D.W.),
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  • ORCID record for Michael Essien
Maxwell E. Cooper
aFrom the Department of Radiology and Imaging Sciences (M.E., M.E.C., A.G., T.L.M., R.H., B.D.W.),
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Ashwani Gore
aFrom the Department of Radiology and Imaging Sciences (M.E., M.E.C., A.G., T.L.M., R.H., B.D.W.),
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Taejin L. Min
aFrom the Department of Radiology and Imaging Sciences (M.E., M.E.C., A.G., T.L.M., R.H., B.D.W.),
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Benjamin B. Risk
bRollins School of Public Health (B.B.R.), Emory University, Atlanta, Georgia
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Gelareh Sadigh
bRollins School of Public Health (B.B.R.), Emory University, Atlanta, Georgia
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Ranliang Hu
aFrom the Department of Radiology and Imaging Sciences (M.E., M.E.C., A.G., T.L.M., R.H., B.D.W.),
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Michael J. Hoch
cDepartment of Radiological Sciences (G.S.), University of California Irvine, Orange, California
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Brent D. Weinberg
aFrom the Department of Radiology and Imaging Sciences (M.E., M.E.C., A.G., T.L.M., R.H., B.D.W.),
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  • FIG 1.
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    FIG 1.

    Bar graph showing relative frequency of BT-RADS scores (from original reports) among selected MR imaging examinations (n = 103).

  • FIG 2.
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    FIG 2.

    Boxplot graph showing time (in months) from the oldest MRI to the prior MRI used by readers to assign a BT-RADS score. The maximum and minimum values are represented at either end of the whiskers. The box represents the interquartile range (25th percentile to the 75th percentile), with the median value represented by the thick horizontal black line within the box. Outliers are shown away from the whiskers and box by the symbol (○).

  • FIG 3.
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    FIG 3.

    Violin graph showing boxplot inside an attenuation plot. The width of the attenuation plot at any region corresponds to the frequency of the data points at that region. For the boxplot, the maximum and minimum values are represented at either end of the whiskers. The box represents the interquartile range (25th percentile to the 75th percentile), with the median value represented by a thick horizontal black line either within the box or at either end of the box. The mean value is represented by the black triangle (▴). Outliers are shown away from the whiskers and box by small black dots (●). On a scale of 1–5 (with 1 = very little, and 5 = great deal), all 6 readers rated how much perfusion contributed to their interpretation of scan and assignment of BT-RADS score.

  • FIG 4.
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    FIG 4.

    Violin graph showing boxplot inside an attenuation plot. The width of the attenuation plot at any region corresponds to the frequency of the data points at that region. For the boxplot, the maximum and minimum values are represented at either end of the whiskers. The box represents the interquartile range (25th percentile to the 75th percentile), with the median value represented by a thick horizontal black line either within the box or at either end of the box. The mean value is represented by the black triangle (▴). Outliers are shown away from the whiskers and box by small black dots (●). On a scale of 1–5 (with 1 = not sure at all, and 5 = absolutely sure), all 6 readers rated their level of confidence for the BT-RADS score they assigned to each case. Neuroradiologists (Faculty_1, Faculty _2, Faculty _3, and Faculty _4); Radiology residents (Resident_1 and Resident_2).

  • FIG 5.
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    FIG 5.

    Imaging from a patient with agreement among all readers. A 48-year-old man with IDH–wild-type glioblastoma. FLAIR (A) and T1 postcontrast (B) imaging 18 months after surgery showing abnormal FLAIR and enhancing treated tumor in the left temporal lobe. FLAIR (C) and T1 postcontrast (D) 2 months later showing marked increase in the size of abnormal masslike FLAIR and enhancement (white arrows) with >25% increase in cross-sectional area. All readers gave the study a score of BT-RADS 4.

  • FIG 6.
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    FIG 6.

    Imaging from a patient with disagreement among readers. A 45-year-old woman with IDH–wild-type glioblastoma. FLAIR (A) and T1 postcontrast (B) imaging 3 months after surgery and 1 month after completing radiation showing multifocal abnormal FLAIR in the bilateral frontal lobes with minimal enhancement in the left frontal lobe (white arrow). FLAIR (C) and T1 postcontrast (D) 2 months later (3 months after completing radiation) showing marked increase in left frontal edema (white arrows) and enhancement (white arrow). One-half of the readers (2 neuroradiologists and 1 resident) gave the study a score of BT-RADS 3a (pseudoprogression) and one-half of the readers gave the study a score of BT-RADS 4 (progression). The post hoc reference score was BT-RADS 4.

Tables

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    Table 1:

    Patient and tumor characteristics

    Characteristic
    Number of patients98
    Number of men52 (53%)
    Number of MRI examinations evaluated103
    Median age [IQR] (yr)53 [41–66]
    Number of patients with previous surgery97 (99%)
    Number of patients with completed radiation therapy89 (91%)
    Number of patients taking steroids18 (18%)
    Number of patients taking bevacizumab20 (20%)
    Tumor classification
     Astrocytoma79 (77%)
     Grade 214 (14%)
     Grade 320 (19%)
     Grade 444 (43%)
     Anaplastic pilocytic astrocytoma1 (1%)
     Oligodendroglioma24 (23%)
      Grade 216 (15%)
      Grade 38 (8%)
    Tumor type by IDH-mutational status
    Astrocytoma
     IDH–wild-type40 (51%)
     IDH-mutant36 (45%)
     Unknown3 (4%)
    Oligodendroglioma
     IDH-mutant19 (79%)
     Unknown5 (21%)
    • View popup
    Table 2:

    Percent agreement between neuroradiologist blinded score and consensus score; blinded score and post hoc reference score (n = 46)

    ReaderAgreement (%) with Consensus ScoreAgreement (%) with Post Hoc Reference Score
    Faculty_16552
    Faculty_24646
    Faculty_35241
    Faculty_46348
    • Note:—Faculty_1, Faculty_3, and Faculty_4 had 3 years of practice experience. Faculty_2 had 1 year of practice experience.

    • View popup
    Table 3:

    Under- and overestimation of disagreement of neuroradiologist blinded score compared with post hoc reference score

    ReaderUnderestimation/Overestimation
    Faculty_114/8
    Faculty_212/13
    Faculty_320/7
    Faculty_417/7
    • Note:—Faculty_1, Faculty_3, and Faculty_4 had 3 years of practice experience. Faculty_2 had 1 year of practice experience.

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American Journal of Neuroradiology: 45 (9)
American Journal of Neuroradiology
Vol. 45, Issue 9
1 Sep 2024
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Cite this article
Michael Essien, Maxwell E. Cooper, Ashwani Gore, Taejin L. Min, Benjamin B. Risk, Gelareh Sadigh, Ranliang Hu, Michael J. Hoch, Brent D. Weinberg
Interrater Agreement of BT-RADS for Evaluation of Follow-up MRI in Patients with Treated Primary Brain Tumor
American Journal of Neuroradiology Sep 2024, 45 (9) 1308-1315; DOI: 10.3174/ajnr.A8322

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BTRADS Agreement in Follow-Up MRI for Brain Tumors
Michael Essien, Maxwell E. Cooper, Ashwani Gore, Taejin L. Min, Benjamin B. Risk, Gelareh Sadigh, Ranliang Hu, Michael J. Hoch, Brent D. Weinberg
American Journal of Neuroradiology Sep 2024, 45 (9) 1308-1315; DOI: 10.3174/ajnr.A8322
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