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Research ArticleNeurointervention

Predictors and Outcomes of Periprocedural Intracranial Hemorrhage after Stenting for Symptomatic Intracranial Atherosclerotic Stenosis

Kaijiang Kang, Peipei Gong, Feng Gao, Dapeng Mo, Xingquan Zhao, Zhongrong Miao and Ning Ma
American Journal of Neuroradiology November 2024, 45 (11) 1716-1722; DOI: https://doi.org/10.3174/ajnr.A8379
Kaijiang Kang
aFrom the Department of Neurology (K.K., X.Z.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
dCenter of Stroke (K.K., F.G., D.M., X.Z., Z.M, N.M.), Beijing Institute for Brain Disorders, Beijing, China
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Peipei Gong
eAffiliated Hospital of Nantong University (P.G.), Medical School of Nantong University, Nantong, China
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Feng Gao
bDepartment of Interventional Neuroradiology (F.G., D.M., Z.M., N.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
cChina National Clinical Research Center for Neurological Diseases (F.G., D.M., X.Z., Z.M., N.M.), Beijing, China
dCenter of Stroke (K.K., F.G., D.M., X.Z., Z.M, N.M.), Beijing Institute for Brain Disorders, Beijing, China
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Dapeng Mo
bDepartment of Interventional Neuroradiology (F.G., D.M., Z.M., N.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
cChina National Clinical Research Center for Neurological Diseases (F.G., D.M., X.Z., Z.M., N.M.), Beijing, China
dCenter of Stroke (K.K., F.G., D.M., X.Z., Z.M, N.M.), Beijing Institute for Brain Disorders, Beijing, China
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Xingquan Zhao
aFrom the Department of Neurology (K.K., X.Z.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
cChina National Clinical Research Center for Neurological Diseases (F.G., D.M., X.Z., Z.M., N.M.), Beijing, China
dCenter of Stroke (K.K., F.G., D.M., X.Z., Z.M, N.M.), Beijing Institute for Brain Disorders, Beijing, China
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Zhongrong Miao
bDepartment of Interventional Neuroradiology (F.G., D.M., Z.M., N.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
cChina National Clinical Research Center for Neurological Diseases (F.G., D.M., X.Z., Z.M., N.M.), Beijing, China
dCenter of Stroke (K.K., F.G., D.M., X.Z., Z.M, N.M.), Beijing Institute for Brain Disorders, Beijing, China
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Ning Ma
bDepartment of Interventional Neuroradiology (F.G., D.M., Z.M., N.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
cChina National Clinical Research Center for Neurological Diseases (F.G., D.M., X.Z., Z.M., N.M.), Beijing, China
dCenter of Stroke (K.K., F.G., D.M., X.Z., Z.M, N.M.), Beijing Institute for Brain Disorders, Beijing, China
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  • FIG 1.
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    FIG 1.

    A patient presented with progressive weakness in the right limbs for 28 days. The DWI of preprocedural MR) revealed subacute infarction in the right internal watershed area (A). Preprocedural CT perfusion showed extensive hypoperfusion in the right intracranial ICA distribution area, and CBF decreased significantly (B). Preprocedural DSA showed severe stenosis in the terminal segment of the right ICA, with a TICI scale of grade 2a (C). The lesion was treated with a 2.5 × 8 mm balloon-mounted Apollo stent (MicroPort Neuro Tech), with a residual stenosis rate of 10% (D). The CT scan immediately after the procedure showed slightly high attenuation in the right frontal lobe and was considered to be leakage of contrast media (E). The transcranial Doppler indicated elevated flow velocity in the right middle cerebral artery. The patient developed lethargy, slurred speech, and aggravation of left limb weakness 5 hours after the procedure, and a re-examination of head CT revealed cerebral hemorrhage in the right frontal lobe (F). After that, antiplatelet and anticoagulant drugs were stopped, and the CT scan 10 hours after the procedure revealed hemorrhage expansion (G). The CT scan 48 hours after the procedure showed that the hematoma had expanded again. The legal representative refused hematoma removal, and the patient died of respiratory and circulatory failure 7 days after the procedure (H).

  • FIG 2.
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    FIG 2.

    The distribution of 30-day (A) and long-term (B) mRS in patients with PRH or NPRH.

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    Table 1:

    Periprocedural characteristics and long-term outcome of patients with periprocedural intracranial hemorrhage after stent placement for symptomatic intracranial atherosclerotic stenosis

    VariablesValues
    Lesion sites, n (%)
     Anterior circulation14 (58.3%)
     Posterior circulation10 (41.7%)
    Hemorrhage locations, n (%)
     Lobar hematoma6 (25.0%)
     Basal ganglia9 (37.5%)
     Cerebellum3 (12.5%)
     Brainstem2 (8.3%)
     Intraventricular hemorrhage1 (4.2%)
     Subarachnoid hemorrhage3 (12.5%)
    Time of hemorrhage occurrence
     Intraprocedure5 (20.8%)
     Within 24 hours after procedure17 (70.8%)
     Beyond 24 hours after procedure2 (8.4%)
    Hemorrhage causes, n (%)
     Procedure-related4 (16.7%)
     Non-procedure-related20 (83.3%)
    mRS at discharge
     0−28 (33.3%)
     3−515 (62.5%)
     61 (4.2%)
    30-day mRS after procedure
     0−29 (37.5%)
     3−55 (20.8%)
     610 (41.7%)
    Long-term (median of 78 months) follow-up mRS
     0−210 (43.5%)
     3−53 (13.0%)
     610 (43.5%)
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    Table 2:

    Multivariate logistic regression of NPRH prediction

    VariablesβOR (95% CI)P Value
    Lesion sites (anterior circulation)1.4804.395 (1.711–11.285).002
    Preprocedural stenosis rate (%)0.1251.133 (1.070–1.200)<.001
    Ischemic stroke within 30 days1.2783.588 (1.446–8.903).006
    Ischemic stroke within 90 days−0.1200.887 (0.240–3.283).858
    Baseline NIHSS0.0111.011 (0.644–1.588).963
    Baseline mRS0.1831.201 (0.752–1.919).443
    Preprocedural TICI scale (0−2a)−0.1740.840 (0.241–2.931).785
    • Note:—Variables included for multivariate analysis: variables with P < .05 in univariate analysis.

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American Journal of Neuroradiology: 45 (11)
American Journal of Neuroradiology
Vol. 45, Issue 11
1 Nov 2024
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Cite this article
Kaijiang Kang, Peipei Gong, Feng Gao, Dapeng Mo, Xingquan Zhao, Zhongrong Miao, Ning Ma
Predictors and Outcomes of Periprocedural Intracranial Hemorrhage after Stenting for Symptomatic Intracranial Atherosclerotic Stenosis
American Journal of Neuroradiology Nov 2024, 45 (11) 1716-1722; DOI: 10.3174/ajnr.A8379

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Intracranial Hemorrhage Post-Stenting Outcomes
Kaijiang Kang, Peipei Gong, Feng Gao, Dapeng Mo, Xingquan Zhao, Zhongrong Miao, Ning Ma
American Journal of Neuroradiology Nov 2024, 45 (11) 1716-1722; DOI: 10.3174/ajnr.A8379
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