Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging
Open Access

Long-Term Imaging Follow-up from the Management of Myelomeningocele Study

E. George, C. MacPherson, S. Pruthi, L. Bilaniuk, J. Fletcher, A. Houtrow, N. Gupta and O.A. Glenn
American Journal of Neuroradiology July 2023, 44 (7) 861-866; DOI: https://doi.org/10.3174/ajnr.A7926
E. George
aFrom the Departments of Radiology and Biomedical Imaging (E.G., O.A.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. George
C. MacPherson
dBiostatistics Center (C.M.), Milken Institute School of Public Health, The George Washington University, Washington, DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. MacPherson
S. Pruthi
eDepartment of Radiology (S.P.), Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, Tennessee
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Pruthi
L. Bilaniuk
fDepartment of Radiology (L.B.), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for L. Bilaniuk
J. Fletcher
gDepartment of Psychology (J.F.), University of Houston, Houston, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Fletcher
A. Houtrow
hDepartment of Physical Medicine and Rehabilitation (A.H.), University of Pittsburgh, Pittsburgh, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Houtrow
N. Gupta
bNeurological Surgery (N.G.)
cPediatrics (N.G.), University of California, San Francisco, San Francisco, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N. Gupta
O.A. Glenn
aFrom the Departments of Radiology and Biomedical Imaging (E.G., O.A.G.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for O.A. Glenn
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Agopian AJ,
    2. Canfield MA,
    3. Olney RS, et al
    ; National Birth Defects Prevention Study. Spina bifida subtypes and sub-phenotypes by maternal race/ethnicity in the National Birth Defects Prevention Study. Am J Med Genet A 2012;158A:109–15 doi:10.1002/ajmg.a.34383 pmid:22140002
    CrossRefPubMed
  2. 2.↵
    1. Boulet SL,
    2. Yang Q,
    3. Mai C, et al
    ; National Birth Defects Prevention Network. Trends in the postfortification prevalence of spina bifida and anencephaly in the United States. Birth Defects Res A Clin Mol Teratol 2008;82:527–32 doi:10.1002/bdra.20468 pmid:18481813
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Parker SE,
    2. Mai CT,
    3. Canfield MA, et al
    ; National Birth Defects Prevention Network. Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006. Birth Defects Res A Clin Mol Teratol 2010;88:1008–16 doi:10.1002/bdra.20735 pmid:20878909
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Rossi A,
    2. Gandolfo C,
    3. Morana G, et al
    . Current classification and imaging of congenital spinal abnormalities. Semin Roentgenol 2006;41:250–73 doi:10.1053/j.ro.2006.07.001 pmid:17010690
    CrossRefPubMed
  5. 5.↵
    1. McLone DG,
    2. Knepper PA
    . The cause of Chiari II malformation: a unified theory. Pediatr Neurosci 1989;15:1–12 doi:10.1159/000120432 pmid:2699756
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Maurice P,
    2. Garel J,
    3. Garel C, et al
    . New insights in cerebral findings associated with fetal myelomeningocele: a retrospective cohort study in a single tertiary centre. BJOG 2021;128:376–83 doi:10.1111/1471-0528.16185 pmid:32112473
    CrossRefPubMed
  7. 7.↵
    1. Ben Miled S,
    2. Loeuillet L,
    3. Duong Van Huyen JP, et al
    . Severe and progressive neuronal loss in myelomeningocele begins before 16 weeks of pregnancy. Am J Obstet Gynecol 2020;223:256 e1–e9 doi:10.1016/j.ajog.2020.02.052 pmid:32283072
    CrossRefPubMed
  8. 8.↵
    1. Vachha B,
    2. Adams R
    . Language differences in young children with myelomeningocele and shunted hydrocephalus. Pediatr Neurosurg 2003;39:184–89 doi:10.1159/000072469 pmid:12944698
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Foss S,
    2. Flanders TM,
    3. Heuer GG, et al
    . Neurobehavioral outcomes in patients with myelomeningocele. Neurosurg Focus 2019;47:E6 doi:10.3171/2019.7.FOCUS19445 pmid:31574480
    CrossRefPubMed
  10. 10.↵
    1. Johnson MP,
    2. Sutton LN,
    3. Rintoul N, et al
    . Fetal myelomeningocele repair: short-term clinical outcomes. Am J Obstet Gynecol 2003;189:482–87 doi:10.1067/s0002-9378(03)00295-3 pmid:14520222
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Tulipan N,
    2. Bruner JP,
    3. Hernanz-Schulman M, et al
    . Effect of intrauterine myelomeningocele repair on central nervous system structure and function. Pediatr Neurosurg 1999;31:183–88 doi:10.1159/000028859 pmid:10705927
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Adzick NS,
    2. Thom EA,
    3. Spong CY, et al
    ; MOMS Investigators. A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med 2011;364:993–1004 doi:10.1056/NEJMoa1014379 pmid:21306277
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Tulipan N,
    2. Wellons JC 3rd.,
    3. Thom EA, et al
    ; MOMS Investigators. Prenatal surgery for myelomeningocele and the need for cerebrospinal fluid shunt placement. J Neurosurg Pediatr 2015;16:613–20 doi:10.3171/2015.7.PEDS15336 pmid:26369371
    CrossRefPubMed
  14. 14.↵
    1. Farmer DL,
    2. Thom EA,
    3. Brock JW 3rd., et al
    ; Management of Myelomeningocele Study Investigators. The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes. Am J Obstet Gynecol 2018;218:256.e13 doi:10.1016/j.ajog.2017.12.001 pmid:29246577
    CrossRefPubMed
  15. 15.↵
    1. Flanders TM,
    2. Heuer GG,
    3. Madsen PJ, et al
    . Detailed analysis of hydrocephalus and hindbrain herniation after prenatal and postnatal myelomeningocele closure: report from a single institution. Neurosurgery 2020;86:637–45 doi:10.1093/neuros/nyz302 pmid:31432079
    CrossRefPubMed
  16. 16.↵
    1. Nagaraj UD,
    2. Bierbrauer KS,
    3. Zhang B, et al
    . Hindbrain herniation in Chiari II malformation on fetal and postnatal MRI. AJNR Am J Neuroradiol 2017;38:1031–36 doi:10.3174/ajnr.A5116 pmid:28279990
    Abstract/FREE Full Text
  17. 17.↵
    1. Houtrow AJ,
    2. Thom EA,
    3. Fletcher JM, et al
    . Prenatal repair of myelomeningocele and school-age functional outcomes. Pediatrics 2020;145:e2019154 doi:10.1542/peds.2019-1544 pmid:31980545
    CrossRefPubMed
  18. 18.↵
    1. Rethmann C,
    2. Scheer I,
    3. Meuli M, et al
    . Evolution of posterior fossa and brain morphology after in utero repair of open neural tube defects assessed by MRI. Eur Radiol 2017;27:4571–80 doi:10.1007/s00330-017-4807-y pmid:28500367
    CrossRefPubMed
  19. 19.↵
    1. Sutton LN,
    2. Adzick NS,
    3. Bilaniuk LT, et al
    . Improvement in hindbrain herniation demonstrated by serial fetal magnetic resonance imaging following fetal surgery for myelomeningocele. JAMA 1999;282:1826–31 doi:10.1001/jama.282.19.1826 pmid:10573273
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Aertsen M,
    2. Verduyckt J,
    3. De Keyzer F, et al
    . Reliability of MR imaging-based posterior fossa and brainstem measurements in open spinal dysraphism in the era of fetal surgery. AJNR Am J Neuroradiol 2019;40:191–98 doi:10.3174/ajnr.A5930 pmid:30591508
    Abstract/FREE Full Text
  21. 21.↵
    1. da Costa MDS,
    2. Nicacio JM,
    3. Dastoli PA, et al
    . Alterations in skull base anatomy in intrauterine and postnatal repaired myelomeningoceles. Childs Nerv Syst 2020;36:2757–63 doi:10.1007/s00381-020-04587-6 pmid:32239293
    CrossRefPubMed
  22. 22.↵
    1. Grant RA,
    2. Heuer GG,
    3. Carrion GM, et al
    . Morphometric analysis of posterior fossa after in utero myelomeningocele repair. J Neurosurg Pediatr 2011;7:362–68 doi:10.3171/2011.1.PEDS10234 pmid:21456906
    CrossRefPubMed
  23. 23.↵
    1. Glenn OA,
    2. Cuneo AA,
    3. Barkovich AJ, et al
    . Malformations of cortical development: diagnostic accuracy of fetal MR imaging. Radiology 2012;263:843–55 doi:10.1148/radiol.12102492 pmid:22495681
    CrossRefPubMed
  24. 24.↵
    1. Kunpalin Y,
    2. Richter J,
    3. Mufti N, et al
    . Cranial findings detected by second-trimester ultrasound in fetuses with myelomeningocele: a systematic review. BJOG 2021;128:366–74 doi:10.1111/1471-0528.16496 pmid:32926566
    CrossRefPubMed
  25. 25.↵
    1. Morais BA,
    2. Solla DJ,
    3. Yamaki VN, et al
    . Brain abnormalities in myelomeningocele patients. Childs Nerv Syst 2020;36:1507–13 doi:10.1007/s00381-019-04386-8 pmid:31664560
    CrossRefPubMed
  26. 26.↵
    1. de Wit OA,
    2. den Dunnen WF,
    3. Sollie KM, et al
    . Pathogenesis of cerebral malformations in human fetuses with meningomyelocele. Cerebrospinal Fluid Res 2008;5:4 doi:10.1186/1743-8454-5-4 pmid:18312688
    CrossRefPubMed
  27. 27.↵
    1. Dennis M,
    2. Salman MS,
    3. Juranek J, et al
    . Cerebellar motor function in spina bifida meningomyelocele. Cerebellum 2010;9:484–98 doi:10.1007/s12311-010-0191-8 pmid:20652468
    CrossRefPubMed
  28. 28.↵
    1. Williams VJ,
    2. Juranek J,
    3. Stuebing K, et al
    . Examination of frontal and parietal tectocortical attention pathways in spina bifida meningomyelocele using probabilistic diffusion tractography. Brain Connect 2013;3:512–22 doi:10.1089/brain.2013.0171 pmid:23937233
    CrossRefPubMed
  29. 29.↵
    1. Cools MJ,
    2. Tang AR,
    3. Pruthi S, et al
    . A comparison of MRI appearance and surgical detethering rates between intrauterine and postnatal myelomeningocele closures: a single-center pilot matched cohort study. Childs Nerv Syst 2023;39:647–53 doi:10.1007/s00381-022-05627-z pmid:35927592
    CrossRefPubMed
  30. 30.↵
    1. Worley G,
    2. Greenberg RG,
    3. Rocque BG, et al
    . Neurosurgical procedures for children with myelomeningocele after fetal or postnatal surgery: a comparative effectiveness study. Dev Med Child Neurol 2021;63:1294–1301 doi:10.1111/dmcn.14792 pmid:33386749
    CrossRefPubMed
  31. 31.↵
    1. Dias MS,
    2. Wang M,
    3. Rizk EB, et al
    ; National Spina Bifida Patient Registry Group. Tethered spinal cord among individuals with myelomeningocele: an analysis of the National Spina Bifida Patient Registry. J Neurosurg Pediatr 2023;7:1–7 doi:10.3171/2023.5.PEDS20868a pmid:33962385
    CrossRefPubMed
  32. 32.↵
    1. Corroenne R,
    2. Zhu KH,
    3. Johnson E, et al
    . Impact of the size of the lesion in prenatal neural tube defect repair on imaging, neurosurgical and motor outcomes: a retrospective cohort study. BJOG 2021;128:392–99 doi:10.1111/1471-0528.16316 pmid:32406575
    CrossRefPubMed
  33. 33.↵
    1. Nagaraj UD,
    2. Bierbrauer KS,
    3. Stevenson CB, et al
    . Myelomeningocele versus myelocele on fetal MR images: are there differences in brain findings? AJR Am J Roentgenol 2018;211:1376–80 doi:10.2214/AJR.18.20088 pmid:30332293
    CrossRefPubMed
  34. 34.↵
    1. Fletcher JM,
    2. Copeland K,
    3. Frederick JA, et al
    . Spinal lesion level in spina bifida: a source of neural and cognitive heterogeneity. J Neurosurg 2005;102:268–79 doi:10.3171/ped.2005.102.3.0268 pmid:15881750
    CrossRefPubMedWeb of Science
  35. 35.↵
    1. Fletcher JM,
    2. Houtrow AJ,
    3. MacPherson C
    . Hydrocephalus and school-age neuropsychological outcomes in the Management of Myelomeningocele prenatal surgery trial: a secondary analysis. J Neurosurg Pediatr 2023 Mar 3. [Epub ahead of print] doi:10.3171/2022.10.PEDS22358 pmid:36883627
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 44 (7)
American Journal of Neuroradiology
Vol. 44, Issue 7
1 Jul 2023
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Long-Term Imaging Follow-up from the Management of Myelomeningocele Study
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
E. George, C. MacPherson, S. Pruthi, L. Bilaniuk, J. Fletcher, A. Houtrow, N. Gupta, O.A. Glenn
Long-Term Imaging Follow-up from the Management of Myelomeningocele Study
American Journal of Neuroradiology Jul 2023, 44 (7) 861-866; DOI: 10.3174/ajnr.A7926

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Long-Term Follow-Up in Myelomeningocele Management
E. George, C. MacPherson, S. Pruthi, L. Bilaniuk, J. Fletcher, A. Houtrow, N. Gupta, O.A. Glenn
American Journal of Neuroradiology Jul 2023, 44 (7) 861-866; DOI: 10.3174/ajnr.A7926
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Frontal Paraventricular Cysts
  • Sodium MRI in Pediatric Brain Tumors
  • FRACTURE MR in Congenital Vertebral Anomalies
Show more Pediatric Neuroimaging

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire