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Research ArticleSpine Imaging and Spine Image-Guided Interventions

Fluoroscopy- and CT-Guided Gold Fiducial Marker Placement for Intraoperative Localization during Spinal Surgery: Review of 179 Cases at a Single Institution—Technique and Safety Profile

C.P. Siminski, C.M. Carr, D.F. Kallmes, M.P. Oien, J.L.D. Atkinson, J.C. Benson, F.E. Diehn, D.K. Kim, G.B. Liebo, V.T. Lehman, A.A. Madhavan, I.T. Mark, P.P. Morris, D.P. Shlapak, J.T. Verdoorn and J.M. Morris
American Journal of Neuroradiology May 2023, 44 (5) 618-622; DOI: https://doi.org/10.3174/ajnr.A7854
C.P. Siminski
aFrom the Mayo Clinic Alix School of Medicine (C.P.S.)
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C.M. Carr
cDepartment of Radiology (C.M.C., D.F.K., M.P.O., F.E.D., D.K.K., G.B.L., V.T.L., A.A.M., I.T.M., P.P.M., D.P.S., J.T.V., J.M.M.), Mayo Clinic, Rochester, Minnesota
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D.F. Kallmes
cDepartment of Radiology (C.M.C., D.F.K., M.P.O., F.E.D., D.K.K., G.B.L., V.T.L., A.A.M., I.T.M., P.P.M., D.P.S., J.T.V., J.M.M.), Mayo Clinic, Rochester, Minnesota
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M.P. Oien
cDepartment of Radiology (C.M.C., D.F.K., M.P.O., F.E.D., D.K.K., G.B.L., V.T.L., A.A.M., I.T.M., P.P.M., D.P.S., J.T.V., J.M.M.), Mayo Clinic, Rochester, Minnesota
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J.L.D. Atkinson
bDepartment of Neuroradiology (J.L.D.A., J.C.B.)
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J.C. Benson
bDepartment of Neuroradiology (J.L.D.A., J.C.B.)
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F.E. Diehn
cDepartment of Radiology (C.M.C., D.F.K., M.P.O., F.E.D., D.K.K., G.B.L., V.T.L., A.A.M., I.T.M., P.P.M., D.P.S., J.T.V., J.M.M.), Mayo Clinic, Rochester, Minnesota
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D.K. Kim
cDepartment of Radiology (C.M.C., D.F.K., M.P.O., F.E.D., D.K.K., G.B.L., V.T.L., A.A.M., I.T.M., P.P.M., D.P.S., J.T.V., J.M.M.), Mayo Clinic, Rochester, Minnesota
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G.B. Liebo
cDepartment of Radiology (C.M.C., D.F.K., M.P.O., F.E.D., D.K.K., G.B.L., V.T.L., A.A.M., I.T.M., P.P.M., D.P.S., J.T.V., J.M.M.), Mayo Clinic, Rochester, Minnesota
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V.T. Lehman
cDepartment of Radiology (C.M.C., D.F.K., M.P.O., F.E.D., D.K.K., G.B.L., V.T.L., A.A.M., I.T.M., P.P.M., D.P.S., J.T.V., J.M.M.), Mayo Clinic, Rochester, Minnesota
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A.A. Madhavan
cDepartment of Radiology (C.M.C., D.F.K., M.P.O., F.E.D., D.K.K., G.B.L., V.T.L., A.A.M., I.T.M., P.P.M., D.P.S., J.T.V., J.M.M.), Mayo Clinic, Rochester, Minnesota
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I.T. Mark
cDepartment of Radiology (C.M.C., D.F.K., M.P.O., F.E.D., D.K.K., G.B.L., V.T.L., A.A.M., I.T.M., P.P.M., D.P.S., J.T.V., J.M.M.), Mayo Clinic, Rochester, Minnesota
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P.P. Morris
cDepartment of Radiology (C.M.C., D.F.K., M.P.O., F.E.D., D.K.K., G.B.L., V.T.L., A.A.M., I.T.M., P.P.M., D.P.S., J.T.V., J.M.M.), Mayo Clinic, Rochester, Minnesota
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D.P. Shlapak
cDepartment of Radiology (C.M.C., D.F.K., M.P.O., F.E.D., D.K.K., G.B.L., V.T.L., A.A.M., I.T.M., P.P.M., D.P.S., J.T.V., J.M.M.), Mayo Clinic, Rochester, Minnesota
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J.T. Verdoorn
cDepartment of Radiology (C.M.C., D.F.K., M.P.O., F.E.D., D.K.K., G.B.L., V.T.L., A.A.M., I.T.M., P.P.M., D.P.S., J.T.V., J.M.M.), Mayo Clinic, Rochester, Minnesota
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J.M. Morris
cDepartment of Radiology (C.M.C., D.F.K., M.P.O., F.E.D., D.K.K., G.B.L., V.T.L., A.A.M., I.T.M., P.P.M., D.P.S., J.T.V., J.M.M.), Mayo Clinic, Rochester, Minnesota
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  • FIG 1.
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    FIG 1.

    Biplane FL was used to place a gold fiducial marker at T4. Sagittal T2WI (A), sagittal T1WI pregadolinium (B), and axial T2WI (F) demonstrate a multilobulated T1-hyperintense, intramedullary mass with fluid-fluid levels and peripheral T2 hypointensity, which was resected and pathologically proved to be a cavernous malformation. C, Anterior-posterior FL image demonstrates the bone access needle traversing the left pedicle of T4. D and E, Postprocedural images for counting purposes show the first and last ribs, respectively, with the fiducial marker in place (arrow). G, Intraprocedural image demonstrates the coaxial bone access needle with the stylet in place and the gold fiducial at the tip of the needle. H, Subsequently, the needle has been removed, and the gold fiducial remains in place at the junction of the pedicle and vertebral body.

  • FIG 2.
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    FIG 2.

    CT-guided gold fiducial marker placement. A and B, Sagittal T2WI and fat-saturated postcontrast T1WI demonstrate an intradural extramedullary, lobulated, homogeneously intensely enhancing mass that was resected and found to be a schwannoma on pathology. D, Intraprocedural axial CT bone windows at T12 demonstrate a coaxial bone access needle located within the left pedicle of T12. C and E, Postprocedural CT MIP and sagittal reconstructions confirm the gold fiducial marker placement in the left T12 pedicle. Arrow points toward gold fiducial marker.

Tables

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    Table 1:

    Cohort and procedural demographics

    Demographics
    Mean age (range)57 (12–96)
    SexMale = 75
    Female = 104
    Level of gold fiducial marker placementC7 = 1
    T1 = 5
    T2 = 5
    T3 = 14
    T4 = 14
    T5 = 18
    T6 = 21
    T7 = 26
    T8 = 21
    T9 = 15
    T10 = 19
    T11 = 15
    T12 = 7
    L3 = 1
    L4 = 1
    MethodCT = 36
    FL  = 143
    Mean radiation dose (range) (mGy)183.43 (13–805)
    Mean FL time (range) (min)3.92 (0.4–15.2)
    No. of wrong-level surgeries0
    No. of different radiologists who performed a gold fiducial marker placement13
    Mean BMI (range)28.9 (16.1–55.8)
    Osteoporosis diagnosisNo = 159
    Yes = 20
    Trainee present?No = 107
    Yes = 72
    Mean procedure duration (range) (min)a51.9 (20–114)
    Mean No. of days when operation was performed after placement (range)3.6 days (0–92)
    • Note:—BMI indicates body mass index.

    • ↵a Entry of the room by physician to room exit time.

    • View popup
    Table 2:

    Comparison between CT- and FL-guided gold fiducial marker placements

    CTFL
    Total cases36143
    Level of gold fiducial marker placementC7 = 1C7 = 0
    T1 = 4T1 = 1
    T2 = 3T2 = 2
    T3 = 6T3 = 8
    T4 = 6T4 = 8
    T5 = 2T5 = 16
    T6 = 2T6 = 19
    T7 = 2T7 = 24
    T8 = 2T8 = 19
    T9 = 1T9 = 14
    T10 = 4T10 = 15
    T11 = 1T11 = 14
    T12 = 2T12 = 5
    L3 = 0L3 = 1
    L4 = 0L4 = 1
    Average radiation dose (range) (mGy)258.92 (80.69–563.56)164.43 (13–805)
    Average procedural time (range) (min)51.19 (31–114)52.09 (20–89)
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American Journal of Neuroradiology: 44 (5)
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C.P. Siminski, C.M. Carr, D.F. Kallmes, M.P. Oien, J.L.D. Atkinson, J.C. Benson, F.E. Diehn, D.K. Kim, G.B. Liebo, V.T. Lehman, A.A. Madhavan, I.T. Mark, P.P. Morris, D.P. Shlapak, J.T. Verdoorn, J.M. Morris
Fluoroscopy- and CT-Guided Gold Fiducial Marker Placement for Intraoperative Localization during Spinal Surgery: Review of 179 Cases at a Single Institution—Technique and Safety Profile
American Journal of Neuroradiology May 2023, 44 (5) 618-622; DOI: 10.3174/ajnr.A7854

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Gold Fiducial Marker Placement in Spinal Surgery
C.P. Siminski, C.M. Carr, D.F. Kallmes, M.P. Oien, J.L.D. Atkinson, J.C. Benson, F.E. Diehn, D.K. Kim, G.B. Liebo, V.T. Lehman, A.A. Madhavan, I.T. Mark, P.P. Morris, D.P. Shlapak, J.T. Verdoorn, J.M. Morris
American Journal of Neuroradiology May 2023, 44 (5) 618-622; DOI: 10.3174/ajnr.A7854
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