Infarct Evolution in Patients with Anterior Circulation Large-Vessel Occlusion Randomized to IV Alteplase and Endovascular Treatment versus Endovascular Treatment Alone

References

1. 1.↵
   1. Sarraj A,
   2. Hassan AE,
   3. Grotta J, et al

   ; SELECT Investigators. Early infarct growth rate correlation with endovascular thrombectomy clinical outcomes: analysis from the SELECT Study. Stroke 2021;52:57–69 doi:10.1161/STROKEAHA.120.030912 pmid:33280550

   CrossRefPubMed
2. 2.↵
   1. Katsanos AH,
   2. Turc G,
   3. Psychogios M, et al

   . Utility of intravenous alteplase prior to endovascular stroke treatment. Neurology 2021;97:e777–84 doi:10.1212/WNL.0000000000012390 pmid:34144996

   Abstract/FREE Full Text
3. 3.↵
   1. Fischer U,
   2. Kaesmacher J,
   3. Strbian D, et al

   ; SWIFT DIRECT Collaborators. Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial. Lancet 2022;400:104–15 doi:10.1016/S0140-6736(22)00537-2 pmid:35810756

   CrossRefPubMed
4. 4.↵
   1. Mitchell PJ,
   2. Yan B,
   3. Churilov L

   ; DIRECT-SAFE Investigators, et al. DIRECT-SAFE: a randomized controlled trial of DIRECT endovascular clot retrieval versus standard bridging therapy. J Stroke 2022;24:57–64 doi:10.5853/jos.2021.03475 pmid:35135060

   CrossRefPubMed
5. 5.↵
   1. LeCouffe NE,
   2. Kappelhof M,
   3. Treurniet KM, et al

   ; MR CLEAN–NO IV Investigators. A randomized trial of intravenous alteplase before endovascular treatment for stroke. N Engl J Med 2021;385:1833–44 doi:10.1056/NEJMoa2107727 pmid:34758251

   CrossRefPubMed
6. 6.↵
   1. Zi W,
   2. Qiu Z,
   3. Li F, et al

   ; DEVT Trial Investigators. Effect of endovascular treatment alone vs intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke: the DEVT Randomized Clinical Trial. JAMA 2021;325:234 doi:10.1161/str.52.suppl_1.44 pmid:33464335

   CrossRefPubMed
7. 7.↵
   1. Turc G,
   2. Tsivgoulis G,
   3. Audebert HJ, et al

   . European Stroke Organisation (ESO)-European Society for Minimally Invasive Neurological Therapy (ESMINT) expedited recommendation on indication for intravenous thrombolysis before mechanical thrombectomy in patients with acute ischemic stroke and anterior circulation large vessel occlusion. J Neurointerv Surg 2022;14:209 doi:10.1136/neurintsurg-2021-018589 pmid:35115395

   Abstract/FREE Full Text
8. 8.↵
   1. Yang P,
   2. Zhang Y,
   3. Zhang L, et al

   ; DIRECT-MT Investigators. Endovascular thrombectomy with or without intravenous alteplase in acute stroke. N Engl J Med 2020;382:1981–93 doi:10.1056/NEJMoa2001123 pmid:32374959

   CrossRefPubMed
9. 9.↵
   1. Suzuki K,
   2. Matsumaru Y,
   3. Takeuchi M, et al

   ; SKIP Study Investigators. Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: the SKIP Randomized Clinical Trial. JAMA 2021;325:244 doi:10.1001/jama.2020.23522 pmid:33464334

   CrossRefPubMed
10. 10.↵
    1. Yoo AJ,
    2. Chaudhry ZA,
    3. Nogueira RG, et al

    . Infarct volume is a pivotal biomarker after intra-arterial stroke therapy. Stroke 2012;43:1323–30 doi:10.1161/STROKEAHA.111.639401 pmid:22426317

    Abstract/FREE Full Text
11. 11.↵
    1. Zaidi SF,
    2. Aghaebrahim A,
    3. Urra X, et al

    . Final infarct volume is a stronger predictor of outcome than recanalization in patients with proximal middle cerebral artery occlusion treated with endovascular therapy. Stroke 2012;43:3238–44 doi:10.1161/STROKEAHA.112.671594 pmid:23160876

    Abstract/FREE Full Text
12. 12.↵
    1. Albers GW,
    2. Goyal M,
    3. Jahan R, et al

    . Relationships between imaging assessments and outcomes in Solitaire with the intention for thrombectomy as primary endovascular treatment for acute ischemic stroke. Stroke 2015;46:2786–94 doi:10.1161/STROKEAHA.115.010710 pmid:26316344

    Abstract/FREE Full Text
13. 13.↵
    1. Al-Ajlan FS,
    2. Goyal M,
    3. Demchuk AM, et al

    ; ESCAPE Trial Investigators. Intra-arterial therapy and post-treatment infarct volumes: insights from the ESCAPE randomized controlled trial. Stroke 2016;47:777–81 doi:10.1161/STROKEAHA.115.012424 pmid:26892284

    Abstract/FREE Full Text
14. 14.↵
    1. Boers AMM,
    2. Jansen IGH,
    3. Beenen LFM, et al

    . Association of follow-up infarct volume with functional outcome in acute ischemic stroke: a pooled analysis of seven randomized trials. J Neurointerv Surg 2018;10:1137–42 doi:10.1136/neurintsurg-2017-013724 pmid:29627794

    Abstract/FREE Full Text
15. 15.↵
    1. Boers AM,
    2. Jansen IG,
    3. Brown S, et al

    . Mediation of the relationship between endovascular therapy and functional outcome by follow-up infarct volume in patients with acute ischemic stroke. JAMA Neurol 2019;76:194 doi:10.1001/jamaneurol.2018.3661 pmid:30615038

    CrossRefPubMed
16. 16.↵
    1. Bala F,
    2. Ospel J,
    3. Mulpur B, et al

    . Infarct growth despite successful endovascular reperfusion in acute ischemic stroke: a meta-analysis. AJNR Am J Neuroradiol 2021;42:1472–78 doi:10.3174/ajnr.A7177 pmid:34083260

    Abstract/FREE Full Text
17. 17.↵
    1. Simonsen CZ,
    2. Mikkelsen IK,
    3. Karabegovic S, et al

    . Predictors of infarct growth in patients with large vessel occlusion treated with endovascular therapy. Front Neurol 2017;8:574 doi:10.3389/fneur.2017.00574 pmid:29163339

    CrossRefPubMed
18. 18.↵
    1. Regenhardt RW,
    2. Etherton MR,
    3. Das AS, et al

    . Infarct growth despite endovascular thrombectomy recanalization in large vessel occlusive stroke. J Neuroimaging 2021;31:155–64 doi:10.1111/jon.12796 pmid:33119954

    CrossRefPubMed
19. 19.↵
    1. Campbell BC,
    2. Christensen S,
    3. Tress BM, et al

    ; EPITHET Investigators. Failure of collateral blood flow is associated with infarct growth in ischemic stroke. J Cereb Blood Flow Metab 2013;33:1168–72 doi:10.1038/jcbfm.2013.77] pmid:23652626

    CrossRefPubMed
20. 20.↵
    1. Ben Hassen W,
    2. Touloupas C,
    3. Benzakoun J, et al

    . Impact of repeated clot retrieval attempts on infarct growth and outcome after ischemic stroke. Neurology 2021;97:e444–53 doi:10.1212/WNL.0000000000012321 pmid:34162721

    Abstract/FREE Full Text
21. 21.↵
    1. Man S,
    2. Aoki J,
    3. Hussain MS, et al

    . Predictors of infarct growth after endovascular therapy for acute ischemic stroke. J Stroke Cerebrovasc Dis 2015;24:401–47 doi:10.1016/j.jstrokecerebrovasdis.2014.09.004 pmid:25499531

    CrossRefPubMed
22. 22.↵
    1. Demeestere J,
    2. Wouters A,
    3. Christensen S, et al

    . Review of perfusion imaging in acute ischemic stroke: from time to tissue. Stroke 2020;51:1017–24 doi:10.1161/STROKEAHA.119.028337 pmid:32008460

    CrossRefPubMed
23. 23.↵
    1. Konduri P,
    2. van Voorst H,
    3. Bucker A, et al

    ; MR CLEAN Trial Investigators. Posttreatment ischemic lesion evolution is associated with reduced favorable functional outcome in patients with stroke. Stroke 2021;52:3523–31 doi:10.1161/STROKEAHA.120.032331 pmid:34289708

    CrossRefPubMed
24. 24.↵
    1. Bucker A,
    2. Boers AM,
    3. Bot JCJ, et al

    ; MR CLEAN Trial Investigators (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). Associations of ischemic lesion volume with functional outcome in patients with acute ischemic stroke: 24-hour versus 1-week imaging. Stroke 2017;48:1233–40 doi:10.1161/STROKEAHA.116.015156 pmid:28351963

    Abstract/FREE Full Text
25. 25.↵
    1. Krongold M,
    2. Almekhlafi MA,
    3. Demchuk AM, et al

    . Final infarct volume estimation on 1-week follow-up MR imaging is feasible and is dependent on recanalization status. Neuroimage Clin 2015;7:1–6 doi:10.1016/j.nicl.2014.10.010 pmid:25429356

    CrossRefPubMed
26. 26.↵
    1. Treurniet KM,
    2. LeCouffe NE,
    3. Kappelhof M, et al

    ; for the MR CLEAN-NO IV Investigators. MR CLEAN-NO IV: intravenous treatment followed by endovascular treatment versus direct endovascular treatment for acute ischemic stroke caused by a proximal intracranial occlusion—study protocol for a randomized clinical trial. Trials 2021;22:141 doi:10.1186/s13063-021-05063-5 pmid:33588908

    CrossRefPubMed
27. 27.↵
    1. Koopman MS,
    2. Berkhemer OA,
    3. Geuskens RR, et al

    ; MR CLEAN Trial Investigators. Comparison of three commonly used CT perfusion software packages in patients with acute ischemic stroke. J Neurointerv Surg 2019;11:1249–56 doi:10.1136/neurintsurg-2019-014822 pmid:31203208

    Abstract/FREE Full Text
28. 28.↵
    1. Koopman MS,
    2. Hoving JW,
    3. Kappelhof M, et al

    ; the MR CLEAN Registry Investigators. Association of ischemic core imaging biomarkers with post-thrombectomy clinical outcomes in the MR CLEAN Registry. Front Neurol 2022;12:77136 doi:10.3389/fneur.2021.771367 pmid:35082746

    CrossRefPubMed
29. 29.↵
    1. Kamnitsas K,
    2. Ledig C,
    3. Newcombe VF, et al

    . Efficient multi-scale 3D CNN with fully connected CRF for accurate brain lesion segmentation. Med Image Anal 2017;36:61–78 doi:10.1016/j.media.2016.10.004 pmid:27865153

    CrossRefPubMed
30. 30.↵
    1. von Kummer R,
    2. Broderick JP,
    3. Campbell BC, et al

    . The Heidelberg Bleeding Classification: classification of bleeding events after ischemic stroke and reperfusion therapy. Stroke 2015;46:2981–86 doi:10.1161/STROKEAHA.115.010049 pmid:26330447

    FREE Full Text
31. 31.↵
    1. Zaidat OO,
    2. Yoo AJ,
    3. Khatri P, et al

    ; Cerebral Angiographic Revascularization Grading (CARG) Collaborators; STIR Revascularization Working Group; STIR Thrombolysis in Cerebral Infarction (TICI) Task Force. Recommendations on angiographic revascularization grading standards for acute ischemic stroke: a consensus statement. Stroke 2013;44:2650–63 doi:10.1161/STROKEAHA.113.001972 pmid:23920012

    FREE Full Text
32. 32.↵
    1. Khatri P,
    2. Neff J,
    3. Broderick JP, et al

    . Revascularization end points in stroke interventional trials: recanalization versus reperfusion in IMS-I. Stroke 2005;36:2400–03 doi:10.1161/01.STR.0000185698.45720.58 pmid:16224088

    Abstract/FREE Full Text
33. 33.↵
    1. Nolan NM,
    2. Regenhardt RW,
    3. Koch MJ, et al

    . Treatment approaches and outcomes for acute anterior circulation stroke patients with tandem lesions. J Stroke Cerebrovasc Dis 2021;30:105478 doi:10.1016/j.jstrokecerebrovasdis.2020.10547 pmid:33248344

    CrossRefPubMed
34. 34.↵
    1. Millán M,
    2. Remollo S,
    3. Quesada H, et al

    . Vessel patency at 24 hours and its relationship with clinical outcomes and infarct volume in REVASCAT Trial (Randomized Trial of Revascularization with Solitaire FR Device Versus Best Medical Therapy in the Treatment of Acute Stroke Due to Anterior Circulation Large Vessel Occlusion Presenting Within Eight Hours of Symptom Onset). Stroke 2017;48:983–89 doi:10.1161/STROKEAHA.116.015455 pmid:28292867

    Abstract/FREE Full Text
35. 35.↵
    1. Qureshi AI,
    2. Hussein HM,
    3. Abdelmoula M, et al

    . Subacute recanalization and reocclusion in patients with acute ischemic stroke following endovascular treatment. Neurocrit Care 2009;10:195–203 doi:10.1007/s12028-008-9161-0 pmid:19051064

    CrossRefPubMedWeb of Science
36. 36.↵
    1. Mosimann PJ,
    2. Kaesmacher J,
    3. Gautschi D, et al

    . Predictors of unexpected early reocclusion after successful mechanical thrombectomy in acute ischemic stroke patients. Stroke 2018;49:2643–51 doi:10.1161/STROKEAHA.118.021685 pmid:30355192

    CrossRefPubMed
37. 37.↵
    1. Renu A,
    2. Millan M,
    3. San Roman L, et al

    ; CHOICE Investigators. Effect of intra-arterial alteplase vs placebo following successful thrombectomy on functional outcomes in patients with large vessel occlusion acute ischemic stroke: the CHOICE Randomized Clinical Trial. JAMA 2022;327:826 doi:10.1001/jama.2022.1645 pmid:35143603

    CrossRefPubMed
38. 38.↵
    1. Peerlings D,
    2. Bennink E,
    3. Dankbaar JW, et al

    ; DUtch acute STroke (DUST) Study Investigators. Variation in arterial input function in a large multicenter computed tomography perfusion study. Eur Radiol 2021;31:8317–25 doi:10.1007/s00330-021-08067-6 pmid:34050385

    CrossRefPubMed
39. 39.↵
    1. Konduri P,
    2. van Kranendonk K,
    3. Boers A, et al

    ; MR CLEAN Trial Investigators (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). The role of edema in subacute lesion progression after treatment of acute ischemic stroke. Front Neurol 2021;12:705221 doi:10.3389/fneur.2021.705221 pmid:34354669

    CrossRefPubMed
40. 40.↵
    1. Goyal M,
    2. McTaggart R,
    3. Ospel JM, et al

    . How can imaging in acute ischemic stroke help us to understand tissue fate in the era of endovascular treatment and cerebroprotection? Neuroradiology 2022;64:1697–707 doi:10.1007/s00234-022-03001-z pmid:35854136

    CrossRefPubMed
41. 41.↵
    1. Boned S,
    2. Padroni M,
    3. Rubiera M, et al

    . Admission CT perfusion may overestimate initial infarct core: the ghost infarct core concept. J Neurointerv Surg 2017;9:66–69 doi:10.1136/neurintsurg-2016-012494 pmid:27566491

    Abstract/FREE Full Text
42. 42.↵
    1. Hoving JW,
    2. Marquering HA,
    3. Majoie CB, et al

    . Volumetric and spatial accuracy of computed tomography perfusion estimated ischemic core volume in patients with acute ischemic stroke. Stroke 2018;49:2368–67 doi:10.1161/STROKEAHA.118.020846 pmid:30355095

    CrossRefPubMed
43. 43.↵
    1. Chen C,
    2. Bivard A,
    3. Lin L, et al

    . Thresholds for infarction vary between gray matter and white matter in acute ischemic stroke: a CT perfusion study. J Cereb Blood Flow Metab 2019;39:536–46 doi:10.1177/0271678X17744453 pmid:29172990

    CrossRefPubMed