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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleSpine Imaging and Spine Image-Guided Interventions
Open Access

Effect of Normal Breathing on the Movement of CSF in the Spinal Subarachnoid Space

C. Gutiérrez-Montes, W. Coenen, M. Vidorreta, S. Sincomb, C. Martínez-Bazán, A.L. Sánchez and V. Haughton
American Journal of Neuroradiology September 2022, 43 (9) 1369-1374; DOI: https://doi.org/10.3174/ajnr.A7603
C. Gutiérrez-Montes
aFrom the Department of Mechanical and Mining Engineering (C.G.-M.), University of Jaén, Jaén, Andalucía, Spain
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W. Coenen
bGrupo de Mecánica de Fluidos, Departamento de Ingeniería Térmica y de Fluidos (W.C.), Universidad Carlos III de Madrid, Madrid, Spain
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M. Vidorreta
cSiemens Healthineers (M.V.), Madrid, Spain
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S. Sincomb
dDepartment of Mechanical and Aerospace Engineering (S.S., A.L.S.), University of California San Diego, San Diego, California
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C. Martínez-Bazán
eDepartment of Structural Mechanics and Hydraulic Engineering (C.M.-B.), University of Granada, Granada, Spain
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  • ORCID record for C. Martínez-Bazán
A.L. Sánchez
dDepartment of Mechanical and Aerospace Engineering (S.S., A.L.S.), University of California San Diego, San Diego, California
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V. Haughton
fDepartment of Radiology (V.H.), School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin
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  • FIG 1.
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    FIG 1.

    A, Schematic overview of the MR imaging setup. The subject, in a supine position, was instructed to breath guided by a video on an external display. Thoracic circumference respiratory bellows were used to monitor breathing. B, High-resolution, whole-spine images were obtained using a 3-block sagittal 3D T2 SPACE sequence, and flow measurements were acquired with a 2D phase-contrast MR imaging sequence at 5 locations along the spinal canal: C2/C3, T2/T3, T6/T7, T10/T11, and L1/L2. At each level, the ROIs corresponding to the SSAS were drawn manually (yellow shaded regions). Images shown correspond to subject 3.

  • FIG 2.
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    FIG 2.

    Results for subject 1. A, Map of flow velocity in centimeters per second across each section at mid-inhalation (left column) and mid-expiration (right column). B, Plot of the flow rate in milliliters per second across each section through the respiratory cycle. C, Plot of temporally filtered flow rate. D, Change in fluid volume through the respiratory cycle with respect to the start of inhalation for each spinal level. E, Amount of fluid moved between adjacent levels (stroke volume) for each section. F, Net volume increase or decrease at each level during inhalation. G, Net volume increase or decrease during expiration.

  • FIG 3.
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    FIG 3.

    Selected results for subjects 1–6. C, D, E/G correspond to those in Fig 2.

Tables

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  • Interindividual variations in stroke volume and in net volume increase during expiration at each spinal level

    SectionStroke Volume (mL)Net Volume Increase during Expiration (mL)
    MinMeanMaxSegmentMinMeanMax
    C2/C30.540.991.66C2/C3–T2/T3–1.54–0.290.17
    T2/T30.621.373.07T2/T3–T6/T7–0.280.230.62
    T6/T70.381.142.58T6/T7–T10/T11–0.51–0.230.02
    T10/T110.571.542.88T10/T11–L1/L2–0.490.090.57
    L1/L20.761.523.07L1/T2–L5/S10.761.523.07
    • Note:—Min indicates minimum; Max, maximum.

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American Journal of Neuroradiology: 43 (9)
American Journal of Neuroradiology
Vol. 43, Issue 9
1 Sep 2022
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Cite this article
C. Gutiérrez-Montes, W. Coenen, M. Vidorreta, S. Sincomb, C. Martínez-Bazán, A.L. Sánchez, V. Haughton
Effect of Normal Breathing on the Movement of CSF in the Spinal Subarachnoid Space
American Journal of Neuroradiology Sep 2022, 43 (9) 1369-1374; DOI: 10.3174/ajnr.A7603

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Breathing Effect on CSF Movement in Spine
C. Gutiérrez-Montes, W. Coenen, M. Vidorreta, S. Sincomb, C. Martínez-Bazán, A.L. Sánchez, V. Haughton
American Journal of Neuroradiology Sep 2022, 43 (9) 1369-1374; DOI: 10.3174/ajnr.A7603
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