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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging
Open Access

Stroke Recurrence in Children with Vertebral Artery Dissecting Aneurysm

Z. Ritchey, T.J. Bernard, L.Z. Fenton, J.A. Maloney, D.M. Mirsky, I. Neuberger, I. Sriram, J. Seinfeld and N.V. Stence
American Journal of Neuroradiology June 2022, 43 (6) 913-918; DOI: https://doi.org/10.3174/ajnr.A7518
Z. Ritchey
aFrom the Department of Radiology (Z.R.), University of Colorado School of Medicine, Aurora, Colorado
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T.J. Bernard
bSection of Child Neurology (T.J.B), Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado
cHemophilia and Thrombosis Center (T.J.B.), University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado
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L.Z. Fenton
dDepartment of Radiology (L.Z.F., JA.M., D.M.M., I.N., N.V.S.), Children's Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado
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J.A. Maloney
dDepartment of Radiology (L.Z.F., JA.M., D.M.M., I.N., N.V.S.), Children's Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado
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D.M. Mirsky
dDepartment of Radiology (L.Z.F., JA.M., D.M.M., I.N., N.V.S.), Children's Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado
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I. Neuberger
dDepartment of Radiology (L.Z.F., JA.M., D.M.M., I.N., N.V.S.), Children's Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado
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I. Sriram
eDepartment of Pediatrics (I.E.), University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado
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J. Seinfeld
fDepartment of Neurosurgery (J.S.), University of Colorado School of Medicine, Aurora, Colorado
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N.V. Stence
dDepartment of Radiology (L.Z.F., JA.M., D.M.M., I.N., N.V.S.), Children's Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado
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Figures

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  • FIG 1.
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    FIG 1.

    Imaging features of VADA. A 6-year-old boy with recurrent posterior circulation infarctions. Coronal CTA (A) and an anterior-posterior image from conventional angiography (B) demonstrate a focal filling defect in a fusiform dilation of the proximal left V3 segment (black arrowhead). C and D, A 7-year-old boy with recurrent posterior circulation infarctions. Axial CTA (C) from presentation shows a focally dilated proximal left V3 segment with a small filling defect (white arrow). Axial CTA (D) after several months of anticoagulation shows that the filling defect has resolved, leaving a saccular outpouching of the same proximal V3 segment (white arrowhead) that was best seen in the axial plane. E and F, Another 7-year-old boy with recurrent posterior infarctions. Axial MRA (E) at presentation shows the focal filling defect in the proximal right V3 segment (white arrow) with focal dilation downstream (white arrowhead). Flow-related enhancement in the entire right vertebral artery was decreased. Axial MRA (F) several months after cervical fusion shows that the filling defect has resolved and the focal dilation is no longer apparent.

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    FIG 2.

    A 3-year-old boy initially presenting with syncope. A, Axial DWI demonstrates multiple areas of diffusion restriction in the posterior circulation. Abnormalities were bilateral and of differing signal intensity on ADC maps, implying different ages (not shown). B, Axial CTA image from the same day as image A shows focal dilation of the left V3 proximal segment (white arrow). This abnormality was not diagnosed at the time of imaging. C, Repeat DWI 3 weeks after initial presentation following new neurologic symptoms while on aspirin demonstrates a new area of restricted diffusion in the left superior cerebellum. D, Conventional angiography, performed 2 days after image C, demonstrates the focal area of left proximal V3 segment dilation and irregularity (black arrow). This abnormality was only present on a single series due to a misalignment of the lateral camera of the biplane, and it was not diagnosed at the time of the procedure. E, Axial DWI obtained 8 weeks after initial presentation following another acute neurologic deterioration while on anticoagulation demonstrates a new area of diffusion restriction in the left thalamus (white arrow). F, Catheter angiogram demonstrates complete coil occlusion of the abnormal vertebral artery segment. No recurrent symptoms or new areas of infarction occurred following this procedure.

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    FIG 3.

    Stroke recurrence in the VADA group.

Tables

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  • Comparison of clinical characteristics at presentation

    CohortVADANon-VADAP Value
    Age (yr)8.94.711.8<.001
    Sex (No.).45
        Male211011
        Female1138
    Initial diagnosis.059
        Stroke261313
        TIA606
    Signs and symptoms (No.)
        Headache1358
        Hemiparesis1367
        Altered mental status1046
        Vision change743
        Ataxia541
        Emesis523
        Dysarthria514
        Seizure422
        Nausea312
        Numbness202
        Abdominal pain110
        Vertigo110
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American Journal of Neuroradiology: 43 (6)
American Journal of Neuroradiology
Vol. 43, Issue 6
1 Jun 2022
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Cite this article
Z. Ritchey, T.J. Bernard, L.Z. Fenton, J.A. Maloney, D.M. Mirsky, I. Neuberger, I. Sriram, J. Seinfeld, N.V. Stence
Stroke Recurrence in Children with Vertebral Artery Dissecting Aneurysm
American Journal of Neuroradiology Jun 2022, 43 (6) 913-918; DOI: 10.3174/ajnr.A7518

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Stroke Recurrence in PEDS Vertebral Aneurysms
Z. Ritchey, T.J. Bernard, L.Z. Fenton, J.A. Maloney, D.M. Mirsky, I. Neuberger, I. Sriram, J. Seinfeld, N.V. Stence
American Journal of Neuroradiology Jun 2022, 43 (6) 913-918; DOI: 10.3174/ajnr.A7518
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