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Research ArticleNeurointervention

Angiographically Occult Subarachnoid Hemorrhage: Yield of Repeat Angiography, Influence of Initial CT Bleed Pattern, and Sources of Diagnostic Error in 242 Consecutive Patients

I. Nguyen, M.T. Caton, D. Tonetti, A. Abla, A. Kim, W. Smith and S.W. Hetts
American Journal of Neuroradiology May 2022, 43 (5) 731-735; DOI: https://doi.org/10.3174/ajnr.A7483
I. Nguyen
aFrom the Department of Neurology (I.N.), University of California, Davis, Sacramento, California
bDepartment of Neurology (I.N., A.K., W.S.)
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M.T. Caton
cRadiology and Biomedical Imaging (M.T.C., S.W.H.)
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D. Tonetti
dNeurological Surgery (D.T., A.A.), University of California, San Francisco, San Francisco, California
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A. Abla
dNeurological Surgery (D.T., A.A.), University of California, San Francisco, San Francisco, California
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A. Kim
bDepartment of Neurology (I.N., A.K., W.S.)
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W. Smith
bDepartment of Neurology (I.N., A.K., W.S.)
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S.W. Hetts
cRadiology and Biomedical Imaging (M.T.C., S.W.H.)
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  • FIG 1.
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    FIG 1.

    A 78-year-old woman with an example of a physiologically occult aneurysm on the initial DSA on the postbleed day 1. A frontal projection (A) with 3D reconstruction shows no source lesion (B). A second DSA on postbleed day 6 had normal findings. The patient was discharged and re-presented with worsening headache on postbleed day 12. A third DSA on postbleed day 12 (C) demonstrated a submillimeter basilar artery perforator blister aneurysm (curved white arrow) that was clipped.

  • FIG 2.
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    FIG 2.

    A 36-year-old woman admitted with an internal carotid artery blister aneurysm, misdiagnosed due to 2 forms of operator-dependent error. The initial DSA (A) shows a perceptual-type interpretive error in that a laterally projecting blister (white arrow) was not recognized. The blister was more evident on the second DSA (B) and perceived but misinterpreted as vasospasm due to developing vasospasm elsewhere (dashed arrows). Finally, the lesion (yellow arrow) was recognized on the third DSA (C) as vasospasm abated. Intraoperative photographs (D) confirm the rupture site (yellow arrow) secured with clipping.

Tables

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  • Summary of data in patients with vascular source identified

    PatientPositive DSA Findings (No.)Timing of Diagnosis (PBD)RebleedSAH PatternSource
    125NoNPMA1 blister aneurysm
    223Day 2NPMPICA dissecting aneurysm
    325NoNPMA1 blister aneurysm
    427NoNPMCervicomedullary AVF
    528NoNPMDistal MCA mycotic aneurysm
    6239Day 37NPMAcomA saccular aneurysm
    735NoNPMA1 dissecting aneurysm
    8312NoNPMBasilar blister aneurysm
    938NoNPMAcomA saccular aneurysm
    1037NoPMCervicomedullary AVF
    11aNA17Day 17NPMAcomA saccular aneurysm
    12aNA2NoNPMAcomA blister aneurysm
    13aNA16Day 16NPMThrombosed R MCA aneurysm
    • Note:—AcomA indicates anterior communicating artery; PBD, postbleed day; NA, not applicable; R, right.

    • ↵a Aneurysm identified at craniotomy.

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American Journal of Neuroradiology: 43 (5)
American Journal of Neuroradiology
Vol. 43, Issue 5
1 May 2022
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Cite this article
I. Nguyen, M.T. Caton, D. Tonetti, A. Abla, A. Kim, W. Smith, S.W. Hetts
Angiographically Occult Subarachnoid Hemorrhage: Yield of Repeat Angiography, Influence of Initial CT Bleed Pattern, and Sources of Diagnostic Error in 242 Consecutive Patients
American Journal of Neuroradiology May 2022, 43 (5) 731-735; DOI: 10.3174/ajnr.A7483

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Angiographically Occult Subarachnoid Hemorrhage: Yield of Repeat Angiography, Influence of Initial CT Bleed Pattern, and Sources of Diagnostic Error in 242 Consecutive Patients
I. Nguyen, M.T. Caton, D. Tonetti, A. Abla, A. Kim, W. Smith, S.W. Hetts
American Journal of Neuroradiology May 2022, 43 (5) 731-735; DOI: 10.3174/ajnr.A7483
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