Reduced Leukoaraiosis, Noncardiac Embolic Stroke Etiology, and Shorter Thrombus Length Indicate Good Leptomeningeal Collateral Flow in Embolic Large-Vessel Occlusion

References

1. 1.↵
   1. Guglielmi V,
   2. LeCouffe NE,
   3. Zinkstok SM, et al

   ; on behalf of the MR-CLEAN Registry Investigators. Collateral circulation and outcome in atherosclerotic versus cardioembolic cerebral large vessel occlusion. Stroke 2019;50:3360–68 doi:10.1161/STROKEAHA.119.026299 pmid:31658903

   CrossRefPubMed
2. 2.↵
   1. van Seeters T,
   2. Biessels GJ,
   3. Kappelle LJ, et al

   ; Dutch Acute Stroke Study (DUST) Investigators. Determinants of leptomeningeal collateral flow in stroke patients with a middle cerebral artery occlusion. Neuroradiology 2016;58:969–77 doi:10.1007/s00234-016-1727-5 pmid:27438804

   CrossRefPubMed
3. 3.↵
   1. Wiegers EJ,
   2. Mulder MJH,
   3. Jansen IG, et al

   ; MR CLEAN Trial and MR CLEAN Registry Investigators. Clinical and imaging determinants of collateral status in patients with acute ischemic stroke in MR CLEAN Trial and Registry. Stroke 2020;51:1493–502 doi:10.1161/STROKEAHA.119.027483 pmid:32279619

   CrossRefPubMed
4. 4.↵
   1. Zhang H,
   2. Prabhakar P,
   3. Sealock R, et al

   . Wide genetic variation in the native pial collateral circulation is a major determinant of variation in severity of stroke. J Cereb Blood Flow Metab 2010;30:923–34 doi:10.1038/jcbfm.2010.10 pmid:20125182

   CrossRefPubMedWeb of Science
5. 5.↵
   1. Lima FO,
   2. Furie KL,
   3. Silva GS, et al

   . The pattern of leptomeningeal collaterals on CT angiography is a strong predictor of long-term functional outcome in stroke patients with large vessel intracranial occlusion. Stroke 2010;41:2316–22 doi:10.1161/STROKEAHA.110.592303 pmid:20829514

   Abstract/FREE Full Text
6. 6.↵
   1. Menon BK,
   2. Smith EE,
   3. Coutts SB, et al

   . Leptomeningeal collaterals are associated with modifiable metabolic risk factors. Ann Neurol 2013;74:241–48 doi:10.1002/ana.23906 pmid:23536377

   CrossRefPubMed
7. 7.↵
   1. Nannoni S,
   2. Sirimarco G,
   3. Cereda CW, et al

   . Determining factors of better leptomeningeal collaterals: a study of 857 consecutive acute ischemic stroke patients. J Neurol 2019;266:582–88 doi:10.1007/s00415-018-09170-3 pmid:30610425

   CrossRefPubMed
8. 8.↵
   1. Fujita K,
   2. Tanaka K,
   3. Yamagami H, et al

   . Detrimental effect of chronic hypertension on leptomeningeal collateral flow in acute ischemic stroke. Stroke 2019;50:1751–57 doi:10.1161/STROKEAHA.119.025142 pmid:31233392

   CrossRefPubMed
9. 9.↵
   1. Giurgiutiu DV,
   2. Yoo AJ,
   3. Fitzpatrick K, et al

   . Severity of leukoaraiosis, leptomeningeal collaterals, and clinical outcomes after intra-arterial therapy in patients with acute ischemic stroke. J Neurointerv Surg 2015;7:326–30 doi:10.1136/neurintsurg-2013-011083 pmid:24721756

   Abstract/FREE Full Text
10. 10.↵
    1. Mark I,
    2. Seyedsaadat SM,
    3. Benson JC, et al

    . Leukoaraiosis and collateral blood flow in stroke patients with anterior circulation large vessel occlusion. J Neurointerv Surg 2020;12:942–45 doi:10.1136/neurintsurg-2019-015652 pmid:31959635

    Abstract/FREE Full Text
11. 11.↵
    1. Rebello LC,
    2. Bouslama M,
    3. Haussen DC, et al

    . Stroke etiology and collaterals: atheroembolic strokes have greater collateral recruitment than cardioembolic strokes. Eur J Neurol 2017;24:762–67 doi:10.1111/ene.13287 pmid:28432712

    CrossRefPubMed
12. 12.↵
    1. Hassler E,
    2. Kneihsl M,
    3. Deutschmann H, et al

    . Relationship between stroke etiology and collateral status in anterior circulation large vessel occlusion. J Neurol 2020;267:3362–70 doi:10.1007/s00415-020-10009-z pmid:32588184

    CrossRefPubMed
13. 13.↵
    1. Qazi EM,
    2. Sohn SI,
    3. Mishra S, et al

    . Thrombus characteristics are related to collaterals and angioarchitecture in acute stroke. Can J Neurol Sci 2015;42:381–88 doi:10.1017/cjn.2015.291 pmid:26365832

    CrossRefPubMed
14. 14.↵
    1. Alves HC,
    2. Treurniet KM,
    3. Dutra BG

    , et al. MR CLEAN Trial Investigators. Associations between collateral status and thrombus characteristics and their impact in anterior circulation stroke. Stroke 2018;49:391–96 doi:10.1161/STROKEAHA.117.019509 pmid:29321337

    Abstract/FREE Full Text
15. 15.↵
    1. Tan IY,
    2. Demchuk AM,
    3. Hopyan J, et al

    . CT angiography clot burden score and collateral score: correlation with clinical and radiologic outcomes in acute middle cerebral artery infarct. AJNR Am J Neuroradiol 2009;30:525–31 doi:10.3174/ajnr.A1408 pmid:19147716

    Abstract/FREE Full Text
16. 16.↵
    1. Mortimer AM,
    2. Little DH,
    3. Minhas KS, et al

    . Thrombus length estimation in acute ischemic stroke: a potential role for delayed contrast enhanced CT. J Neurointerv Surg 2014;6:244–48 doi:10.1136/neurintsurg-2013-010769 pmid:23703246

    Abstract/FREE Full Text
17. 17.↵
    1. Tan JC,
    2. Dillon WP,
    3. Liu S, et al

    . Systematic comparison of perfusion-CT and CT-angiography in acute stroke patients. Ann Neurol 2007;61:533–43 doi:10.1002/ana.21130 pmid:17431875

    CrossRefPubMedWeb of Science
18. 18.↵
    1. Liebeskind DS,
    2. Sanossian N,
    3. Yong WH, et al

    . CT and MRI early vessel signs reflect clot composition in acute stroke. Stroke 2011;42:1237–43 doi:10.1161/STROKEAHA.110.605576 pmid:21393591

    Abstract/FREE Full Text
19. 19.↵
    1. Merino JG

    . White matter hyperintensities on magnetic resonance imaging: what is a clinician to do? Mayo Clin Proc 2019;94:380–82 doi:10.1016/j.mayocp.2019.01.016 pmid:30832786

    CrossRefPubMed
20. 20.↵
    1. Sanossian N,
    2. Ovbiagele B,
    3. Saver JL, et al

    . Luekoaraiosis and collaterals in acute ischemic stroke. J Neuroimaging 2011;21:232–35 doi:10.1111/j.1552-6569.2010.00512.x pmid:20977524

    CrossRefPubMedWeb of Science
21. 21.↵
    1. Zhang C,
    2. Wang Y,
    3. Zhao X

    , et al. Chinese IntraCranial AtheroSclerosis (CICAS) Study Group. Factors associated with severity of leukoaraiosis in first-ever lacunar stroke and atherosclerotic ischemic stroke patients. J Stroke Cerebrovasc Dis 2014;23:2862–68 doi:10.1016/j.jstrokecerebrovasdis.2014.07.021 pmid:25280817

    CrossRefPubMed
22. 22.↵
    1. Lin Q,
    2. Huang WQ,
    3. Ma QL, et al

    . Incidence and risk factors of leukoaraiosis from 4683 hospitalized patients: a cross-sectional study. Medicine (Baltimore) 2017;96:e7682 doi:10.1097/MD.0000000000007682 pmid:28953609

    CrossRefPubMed
23. 23.↵
    1. Jing Z,
    2. Shi C,
    3. Zhu L, et al

    . Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment. J Cereb Blood Flow Metab 2015;35:1249–59 doi:10.1038/jcbfm.2015.55 pmid:25853908

    CrossRefPubMed
24. 24.↵
    1. Tu HT,
    2. Campbell BC,
    3. Christensen S, et al

    ; Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) Investigators. Pathophysiological determinants of worse stroke outcome in atrial fibrillation. Cerebrovasc Dis 2010;30:389–95 doi:10.1159/000316886 pmid:20693794

    CrossRefPubMed
25. 25.↵
    1. Souza LC,
    2. Yoo AJ,
    3. Chaudhry ZA, et al

    . Malignant CTA collateral profile is highly specific for large admission DWI infarct core and poor outcome in acute stroke. AJNR Am J Neuroradiol 2012;33:1331–36 doi:10.3174/ajnr.A2985 pmid:22383238

    Abstract/FREE Full Text
26. 26.↵
    1. Liebeskind DS,
    2. Tomsick TA,
    3. Foster LD, et al

    . Collaterals at angiography and outcomes in the Interventional Management of Stroke (IMS) III trial. Stroke 2014;45:759–64 doi:10.1161/STROKEAHA.113.004072 pmid:24473178

    Abstract/FREE Full Text
27. 27.↵
    1. Leng X,
    2. Fang H,
    3. Leung TW, et al

    . Impact of collaterals on the efficacy and safety of endovascular treatment in acute ischaemic stroke: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry 2016;87:537–44 doi:10.1136/jnnp-2015-310965 pmid:26063928

    Abstract/FREE Full Text
28. 28.↵
    1. Jansen IG,
    2. Mulder MJ,
    3. Goldhoorn RB, et al

    ; MR CLEAN Registry Investigators. Impact of single phase CT angiography collateral status on functional outcome over time: results from the MR CLEAN Registry. J Neurointerv Surg 2019;11:866–73 doi:10.1136/neurintsurg-2018-014619 pmid:30777890

    Abstract/FREE Full Text
29. 29.↵
    1. Smit EJ,
    2. Vonken EJ,
    3. van Seeters T, et al

    . Timing-invariant imaging of collateral vessels in acute ischemic stroke. Stroke 2013;44:2194–99 doi:10.1161/STROKEAHA.111.000675 pmid:23760216

    Abstract/FREE Full Text
30. 30.↵
    1. Menon BK,
    2. d’Esterre CD,
    3. Qazi EM, et al

    . Multiphase CT angiography: a new tool for the imaging triage of patients with acute ischemic stroke. Radiology 2015;275:510–20 doi:10.1148/radiol.15142256 pmid:25633505

    CrossRefPubMed