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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Review ArticleReview Article

Head CT: Toward Making Full Use of the Information the X-Rays Give

K.A. Cauley, Y. Hu and S.W. Fielden
American Journal of Neuroradiology August 2021, 42 (8) 1362-1369; DOI: https://doi.org/10.3174/ajnr.A7153
K.A. Cauley
aFrom the Department of Radiology (K.A.C.), Geisinger Medical Center, Danville, Pennsylvania
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Y. Hu
bDepartment of Biomedical & Translational Informatics (Y.H.), Geisinger Medical Center, Danville, Pennsylvania
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S.W. Fielden
cGeisinger Autism & Developmental Medicine Institute (S.W.F.), Lewisburg, Pennsylvania.
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  • FIG 1.
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    FIG 1.

    Change in brain parenchymal fraction through the life span, men (filled) and women (unfilled). This figure summarizes the findings further detailed in Cauley et al.7

  • FIG 2.
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    FIG 2.

    A, Segmentation of T1-weighted MR image of the brain, reprinted with permission from Despotović et al.27 B, Segmentation of a brain CT image, reprinted with permission from Cauley et al.6

  • FIG 3.
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    FIG 3.

    Quantile regression of adult brain parenchymal fraction (men, left and women, right) as a function of age. Quantile regression of adult brain mass (men, left and women, right) as a function of age.

  • FIG 4.
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    FIG 4.

    The effects of image rotation on radiodensity histogram and volumetrics of brain CT images. A, Original image. Volume calculated 1565 mL. B, Image rotated 15° to the right. Volume calculated 1602 mL. C, Rotated image registered to standard brain MR imaging template in FSL to restore image to nonrotated orientation. Volume calculated 2022 mL.

  • FIG 5.
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    FIG 5.

    Beam-hardening by the skull is seen in routine clinical head CT. These images were acquired on 11/14/2018 from a standard hospital GE Healthcare scanner for acute trauma. For the image pair on the left the default display window settings were used (window width/window length 125/40). For the image pair on the right (same case), the display window settings were window width/window length 17/42. This persistent beam-hardening artifact can impact the interpretation of cortical lesions and is particularly important when performing quantitative, digital analysis.

  • FIG 6.
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    FIG 6.

    Image inhomogeneity seen on routine MR images of the brain, with image intensity inhomogeneity–corrected image on the right. Reproduced with permission from Vovk et al.44

  • FIG 7.
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    FIG 7.

    FSL “Bias field reduction” corrects for the attenuation and scatter artifacts seen on routine clinical head CT images. Subject with a thick skull and normal head CT (A). Brain-extracted image (B). Segmented GM images with “bias field correction” “turned off” (C), and with bias field “on” at default settings (D). The magnitude of the correction in HU, color-scaled as per the color bar at the bottom (E). Reproduced with permission from Cauley et al.6

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American Journal of Neuroradiology: 42 (8)
American Journal of Neuroradiology
Vol. 42, Issue 8
1 Aug 2021
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Cite this article
K.A. Cauley, Y. Hu, S.W. Fielden
Head CT: Toward Making Full Use of the Information the X-Rays Give
American Journal of Neuroradiology Aug 2021, 42 (8) 1362-1369; DOI: 10.3174/ajnr.A7153

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Head CT: Toward Making Full Use of the Information the X-Rays Give
K.A. Cauley, Y. Hu, S.W. Fielden
American Journal of Neuroradiology Aug 2021, 42 (8) 1362-1369; DOI: 10.3174/ajnr.A7153
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