Article Figures & Data
Figures
- FIG 1.
Illustrative cases of cervical sagittal MP2RAGE views (T1inv2 and T1Q) acquired in healthy controls (upper row), patients with mild DCM (middle row), and moderate-to-severe DCM (lower row). M indicates mild; M&S, moderate and severe.
- FIG 2.
Postprocessing of the T1 data from cord segmentation to WM/GM ROI analysis, per vertebral and disc levels. A T1Q threshold of 2 seconds was used to check the cord segmentation. Segmentation was performed using the PAM50 atlas.34,35 Quantifications were performed in the subject space.
- FIG 3.
Boxplots of cervical spinal cord T1 values (in milliseconds) in noncompressed disc levels for the 10 healthy controls (HC-0 grade 0; mean T1, 920 [SD, 27] ms) compared with noncompressed (P-0 grade 0; mean T1, 958 [SD, 39] ms), mildly (P-1 grade I; mean T1, 966 [SD, 51] ms), moderately (P-2 grade II; mean T1, 959 [SD, 40] ms), and severely (P-3 grade III; mean T1, 995 [SD, 60] ms) compressed disc levels for the 20 patients. C1 and C2–C3 to C6–C7 disc levels were considered for each subject (6 levels in total). Grade 0 in patients and healthy controls were considered separately because they present statistical different values. The horizontal blue lines represent the mean value in each group. The horizontal lines within and at the ends of the boxes represent the median value and the first and third quartiles, respectively. The whiskers illustrate the minimum and maximum values. The horizontal green lines demonstrate statistically significant differences between the stenosis grades.
- FIG 4.
Distribution of the cervical spinal cord T1 values (milliseconds) according to the vertebral levels in the healthy subjects (green, no statistical difference between the different cervical levels) and patients with mild (orange) and moderate-to-severe (red) DCM. The horizontal bars represent the SD for each level.
- FIG 5.
Boxplots of the T1 values at C1, Cmax, and C7 in the control (green), mild (orange), and moderate-to-severe (red) DCM groups. Horizontal green lines represent statistically significant differences among the clinical groups (P < .05).
- FIG 6.
Distribution of the T1 values (milliseconds) for each clinical group according to the vertebral levels, in the entire spinal cord (blue), white matter (green), and anterior gray matter (yellow). Vertical bars represent the SD for each level.
Tables
Summary of the global observations and statistical analyses according to radiologic/clinical settings and regionalized T1-mapping
Radiologic and Clinical Settings Regionalized T1 Mapping Global Observations Statistical Significance Clinical onset SC at C1, Cmax, C7 T1 values acute > chronic No Cervical spinal canal stenosis SC at disc levels T1 values increase according to the severity of the stenosis (T1grade0 < T1grade1 < T1grade3) Grades 3/0; 3/1 (considering all subjects)Grades 3/0_HC, 2/0_HC, 1/0_HC, 0/0_HC (differentiating patients and HC grade 0) OSS Entire cervical SC Lower T1 values in the mild-stenosis group Mild-vs-moderate OSS Clinical severity Entire cervical SC T1 values increase according to the clinical severity(T1control < T1mild < T1moderate-to-severe) HC and patients with moderate-to-severe DCM Inverse relationship between global T1 values and preoperative mJOA scores Yes SC at C1, Cmax, C7 T1 values increase at C1, Cmax, C7 according to the clinical severity HC and patients with moderate-to-severe DCM (C1, Cmax, and C7)Patients with mild and moderate-to-severe DCM (Cmax)No statistical difference between controls and patients with mild DCM WM, anterior and intermediate GM at C1, Cmax, C7 Global T1-value increase at C1, Cmax, C7 in the WM and GM according to the clinical severity HC and patients with moderate-to-severe DCM (Cmax and C7 in WM and Cmax in GM)Patients with mild and moderate-to-severe DCM (C1 and Cmax in WM, Cmax in GM)No statistical difference between controls and patients with mild DCM
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