Article Figures & Data
Figures
- FIG 1.
Flow chart: exclusion and inclusion criteria.
- FIG 2.
Pathways for management of patients with acute ischemic stroke from symptom onset to mechanical thrombectomy.
Tables
- Table 1:
Mothership patients—characteristics and comparison between patients in nighttime and daytime hours—univariate analysisa
All (N = 95) Nighttime Hours (n = 29) Daytime Hours (n = 66) P Value Age (yr) 76 (62–84) 69 (59–83) 78 (71–84) .09 Men 46 (48) 15 (52) 31 (47) .82 Hypertension 60 (63) 17 (59) 43 (65) .64 Diabetes mellitus 14 (15) 5 (17) 9 (14) .75 Dyslipidemia 38 (40) 10 (34) 28 (42) .50 Atrial fibrillation 29 (31) 12 (41) 17 (26) .20 Smoking 21 (22) 9 (31) 12 (18) .20 Tandem occlusion 14 (15) 4 (14) 10 (15) 1.00 NIHSS at admission 18 (11–21.5) 20 (6–22) 15 (10–20) .03 IV rtPA 57 (60) 10 (34) 28 (42) .50 ASPECTS 7 (5–7) 7 (5–7) 7 (5–8) 1.00 Infarct volume (mL) 18.8 (8.4–41) 29.8 (12–45.5) 18.3 (6.3–34) .20 General anesthesia 41 (43) 14 (48) 27 (41) .51 First-pass success 30 (32) 13 (45) 17 (26) .09 mTICI > 2b 63 (66) 21 (72) 42 (64) .50 Symptom onset to CSC admission (min) 170 (89.5–404) 170 (98–406) 170 (82–392) .61 CSC admission to groin puncture (min) 93 (72–118) 115 (88–132.5) 86 (66–111) .001 CSC admission to reperfusion (min) 168 (129–202) 176 (144–203) 168 (128–199) .55 Groin puncture to reperfusion (min) 60 (43–90) 49 (33–81) 64 (43–95) .11 ENI 28 (29) 10 (33) 18 (28) .48 END 42 (44) 12 (41) 30 (46) .82 sICH 8 (8) 1 (3) 7 (11) .43 In-hospital mortality 18 (19) 1 (3) 17 (26) .01 mRS ≤2 at 90 days 37 (39) 13 (45) 24 (36) .50 ↵a Categoric variables are expressed as number (%), and continuous variables, as median (IQR).
- Table 2:
Patients subject to drip and ship—characteristics and comparison between patients in nighttime and daytime hours—univariate analysisa
All (N = 74) Nighttime Hours (n = 28) Daytime Hours (n = 46) P Value Age (yr) 73 (64.3–82) 71 (63–82) 75 (64.5–82) .60 Men 39 (53) 15 (54) 24 (52) 1.00 Hypertension 53 (72) 17 (61) 36 (78) .12 Diabetes mellitus 14 (19) 4 (14) 10 (22) .55 Dyslipidemia 24 (32) 6 (21) 18 (39) .13 Atrial fibrillation 25 (34) 11 (39) 14 (30) .46 Smoking 23 (31) 6 (21) 17 (37) .20 Tandem occlusion 16 (22) 6 (21) 10 (22) 1.00 NIHSS at admission 16 (11–19.8) 16 (9–19) 16 (11.5–20) .90 IV rtPA 39 (53) 17 (61) 22 (48) .34 ASPECTS 7 (6–8) 7 (6–8) 7 (6–8) .70 Infarct volume (mL) 24.9 (10.7–6.8) 15.4 (9.7–36.7) 26.2 (11.3–4.1) .20 General anesthesia 39 (53) 13 (46) 26 (57) .47 First-pass success 24 (32) 8 (29) 16 (35) .62 mTICI > 2b 61 (82) 23 (82) 38 (82) 1.00 Symptom onset to CSC admission (min) 298 (256–481) 277 (228–374) 302 (271–531) .20 CSC admission to groin puncture (min) 71 (55–99) 85 (66–105) 67 (54–92) .11 CSC admission to reperfusion (min) 152 (101–200) 164 (101–189) 147 (107–210) .90 Groin puncture to reperfusion (min) 70 (47–106) 68 (47–78) 75.5 (49–125) .21 ENI 28 (38) 12 (43) 16 (35) .62 END 14 (19) 4 (14) 10 (22) .55 sICH 8 (11) 2 (7) 6 (13) .70 In-hospital mortality 5 (7) 2 (7) 3 (7) 1.00 mRS ≤2 at 90 days 31 (42) 16 (57) 15 (33) .05 ↵a Categoric variables are expressed as numbers (%), and continuous variables, as median (IQR).
- Table 3:
Characteristics and comparison between good outcome (mRS 0–2) and bad outcome (mRS 3–6) among patients in nighttime hours—predictive factors of favorable outcomea
All (N = 57) mRS (0–2) (n = 29) mRS (3–6) (n = 28) P Value Age (yr) 70 (60–83) 69 (58–73) 79 (62–85.5) .05 Men 30 (53) 17 (59) 13 (46) .43 Hypertension 34 (60) 16 (55) 18 (64) .60 Diabetes mellitus 9 (16) 4 (14) 5 (18) .73 Dyslipidemia 16 (28) 8 (28) 8 (29) 1.00 Atrial fibrillation 23 (40) 10 (34) 13 (46) .42 Smoking 20 (35) 11 (38) 9 (32) .78 Tandem occlusion 10 (18) 4 (14) 6 (21) .50 NIHSS at admission 18 (14–22) 16 (9–20) 19 (17–23) .01 IV rtPA 27 (47) 15 (52) 12 (43) .60 ASPECTS 7 (5–8) 7 (5–7) 7 (5.75–8) .43 Infarct volume 23 (11–45) 23 (11–47) 25 (10.5–37.3) .73 General anesthesia 29 (51) 13 (45) 16 (57) .43 First-pass success 21(37) 15 (52) 6 (21) .03 mTICI >2 44 (77) 28 (97) 16 (57) .0004 CSC admission to groin puncture (min) 94 (78–123) 87 (77–110) 108 (84−135.5) .11 Symptom to groin puncture (min) 361 (272–487) 360 (272–485) 261 (273–494) .82 Groin puncture to reperfusion (min) 56.5 (39–76) 51 (38–69) 64 (42–80) .43 CSC admission to reperfusion (min) 168 (128–195) 147 (123–188) 178 (153–207) .09 ENI 22 (39) 13 (45) 9 (32) .42 END 12 (25) 3 (10) 9 (32) .06 sICH 3 0 (0) 3 (11) .11 In-hospital mortality 3 0 (0) 3 (11) .11 ↵a Categoric variables are expressed as numbers (%), and continuous variables, as median (IQR).
