Correlation between ASPECTS and Core Volume on CT Perfusion: Impact of Time since Stroke Onset and Presence of Large-Vessel Occlusion

S. Nannoni; F. Ricciardi; D. Strambo; G. Sirimarco; M. Wintermark; V. Dunet; P. Michel

doi:10.3174/ajnr.A6959

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FIG 1.
Boxplot of ASPECTS (x-axis) and baseline CTP core volumes (y-axis) in the overall population (n = 1046, A) and in subgroup of late-arriving patients with LVO (n = 151, B). We observe a moderate ASPECTS-CTP core correlation in our study cohort (ρ = –0.49) and a stronger correlation among late-arriving patients with LVO (ρ = –0.57).

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Table 1:

Significant results from the multiple regression model with NCCT ASPECTS as dependent variable in the overall population and in late-arriving (>6 hours from LPGH) patients with AIS with LVO^a

Variables Associated with ASPECTS	Study Cohort (n = 1046)	Late AIS with LVO (n = 151)
Age (yr)	0.02 (0.01–0.03)	0.05 (0.02–0.07)
LPGH to arrival time (h)	−0.11 (−0.15 to −0.08)	−0.21 (−0.30 to −0.12)
Prestroke statin use	0.67 (0.13–1.21)	NS
Acute glucose (g/L)	−0.07 (−0.13 to −0.01)	NS
Hyperdense MCA sign	−0.56 (−0.98 to −0.14)	NS
LVO^{^b}	−0.73 (−1.26 to −0.20)	−
CBS	0.14 (0.06–0.21)	0.17 (0.03–0.31)
Good collaterals	0.87 (0.51–1.23)	NS
Core volume, per 10 mL	−0.10 (−0.14 to −0.07)	−0.21 (−0.27 to −0.15)

Note:—NS indicates nonsignificant; −, variable was non included in the model.
a Results are expressed as β coefficient and relative 95% CI.
↵b Included in the predictive model for the entire study cohort only.

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Table 2:

Independent predictors of good clinical outcome at 3 months (mRS ≤2) in the overall population and in late-arriving (>6 hours from LPGH) patients with AIS with LVO^a

Variables Associated with Good Outcome	Study Cohort (n = 1046)	Late AIS with LVO (n = 151)
Age (yr)	0.96 (0.94–0.97)	NS
NIHSS on admission	0.87 (0.84–0.91)	0.86 (0.80–0.93)
Decreased LOC on admission	0.45 (0.24–0.83)	NS
LPGH to arrival time (h)	0.95 (0.91–0.99)	NS
NCCT ASPECTS	1.10 (1.00–1.20)	1.23 (1.02–1.51)
CBS	1.17 (1.08–1.28)	NS
Tandem occlusion	0.54 (0.32–0.92)	0.23 (0.06–0.76)
	AIC = 694.76	AIC = 146.02

Note:—LOC indicates level of consciousness; AIC, Akaike Information Criteria.
a Results are adjusted for prestroke mRS and expressed as odds ratio and relative 95% CI.