Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention

Local Intra-arterial Thrombolysis during Mechanical Thrombectomy for Refractory Large-Vessel Occlusion: Adjunctive Chemical Enhancer of Thrombectomy

S.H. Baik, C. Jung, J.Y. Kim, D.-W. Shin, B.J. Kim, J. Kang, H.-J. Bae and J.H. Kim
American Journal of Neuroradiology November 2021, 42 (11) 1986-1992; DOI: https://doi.org/10.3174/ajnr.A7264
S.H. Baik
aFrom the Department of Radiology (S.H.B., C.J., D.-W.S., J.H.K.,)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S.H. Baik
C. Jung
aFrom the Department of Radiology (S.H.B., C.J., D.-W.S., J.H.K.,)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Jung
J.Y. Kim
bDepartment of Neurology (J.Y.K., B.J.K., J.K., H.-J.B.), Seoul National University Bundang Hospital, Seongnam, Republic of Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.Y. Kim
D.-W. Shin
aFrom the Department of Radiology (S.H.B., C.J., D.-W.S., J.H.K.,)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.-W. Shin
B.J. Kim
bDepartment of Neurology (J.Y.K., B.J.K., J.K., H.-J.B.), Seoul National University Bundang Hospital, Seongnam, Republic of Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B.J. Kim
J. Kang
bDepartment of Neurology (J.Y.K., B.J.K., J.K., H.-J.B.), Seoul National University Bundang Hospital, Seongnam, Republic of Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Kang
H.-J. Bae
bDepartment of Neurology (J.Y.K., B.J.K., J.K., H.-J.B.), Seoul National University Bundang Hospital, Seongnam, Republic of Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for H.-J. Bae
J.H. Kim
aFrom the Department of Radiology (S.H.B., C.J., D.-W.S., J.H.K.,)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.H. Kim
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Liebeskind DS,
    2. Bracard S,
    3. Guillemin F, et al
    . HERMES Collaborators. eTICI reperfusion: defining success in endovascular stroke therapy. J Neurointerv Surg 2019;11:433–38 doi:10.1136/neurintsurg-2018-014127 pmid:30194109
    Abstract/FREE Full Text
  2. 2.↵
    1. Rizvi A,
    2. Seyedsaadat SM,
    3. Murad MH, et al
    . Redefining ‘success’: a systematic review and meta-analysis comparing outcomes between incomplete and complete revascularization. J Neurointerv Surg 2019;11:9–13 doi:10.1136/neurintsurg-2018-013950 pmid:29802163
    Abstract/FREE Full Text
  3. 3.↵
    1. Yoo AJ,
    2. Andersson T
    . Thrombectomy in acute ischemic stroke: challenges to procedural success. J Stroke 2017;19:121–30 doi:10.5853/jos.2017.00752 pmid:28592779
    CrossRefPubMed
  4. 4.↵
    1. Kaesmacher J,
    2. Gralla J,
    3. Mosimann PJ, et al
    . Reasons for reperfusion failures in stent-retriever-based thrombectomy: registry analysis and proposal of a classification system. AJNR Am J Neuroradiol 2018;39:1848–53 doi:10.3174/ajnr.A5759 pmid:30166434
    Abstract/FREE Full Text
  5. 5.↵
    1. Leischner H,
    2. Flottmann F,
    3. Hanning U, et al
    . Reasons for failed endovascular recanalization attempts in stroke patients. J Neurointerv Surg 2019;11:439–42 doi:10.1136/neurintsurg-2018-014060 pmid:30472671
    Abstract/FREE Full Text
  6. 6.↵
    1. Gascou G,
    2. Lobotesis K,
    3. Machi P, et al
    . Stent retrievers in acute ischemic stroke: complications and failures during the perioperative period. AJNR Am J Neuroradiol 2014;35:734–40 doi:10.3174/ajnr.A3746 pmid:24157734
    Abstract/FREE Full Text
  7. 7.↵
    1. Kim BM
    . Causes and solutions of endovascular treatment failure. J Stroke 2017;19:131–42 doi:10.5853/jos.2017.00283 pmid:28592777
    CrossRefPubMed
  8. 8.↵
    1. Xu H,
    2. Peng S,
    3. Quan T, et al
    . Tandem stents thrombectomy as a rescue treatment for refractory large vessel occlusions. J Neurointerv Surg 2021;13:33–38 doi:10.1136/neurintsurg-2020-015822 pmid:32641417
    Abstract/FREE Full Text
  9. 9.↵
    1. Heiferman DM,
    2. Li DD,
    3. Pecoraro NC, et al
    . Intra-arterial alteplase thrombolysis during mechanical thrombectomy for acute ischemic stroke. J Stroke Cerebrovasc Dis 2017;26:3004–08 doi:10.1016/j.jstrokecerebrovasdis.2017.07.031 pmid:28843804
    CrossRefPubMed
  10. 10.↵
    1. Yi TY,
    2. Chen WH,
    3. Wu YM, et al
    . Adjuvant intra-arterial rt-PA injection at the initially deployed Solitaire stent enhances the efficacy of mechanical thrombectomy in acute ischemic stroke. J Neurol Sci 2018;386:69–73 doi:10.1016/j.jns.2018.01.012 pmid:29406970
    CrossRefPubMed
  11. 11.↵
    1. Zaidi SF,
    2. Castonguay AC,
    3. Jumaa MA, et al
    . Intraarterial thrombolysis as rescue therapy for large vessel occlusions. Stroke 2019;50:1003–06 doi:10.1161/STROKEAHA.118.024442 pmid:30791829
    CrossRefPubMed
  12. 12.↵
    1. Kaesmacher J,
    2. Bellwald S,
    3. Dobrocky T, et al
    . Safety and efficacy of intra-arterial urokinase after failed, unsuccessful, or incomplete mechanical thrombectomy in anterior circulation large-vessel occlusion stroke. JAMA Neurol 2020;77:318–26 doi:10.1001/jamaneurol.2019.4192 pmid:31816018
    CrossRefPubMed
  13. 13.↵
    1. Anadani M,
    2. Ajinkya S,
    3. Alawieh A, et al
    . Intra-arterial tissue plasminogen activator is a safe rescue therapy with mechanical thrombectomy. World Neurosurg 2019;123:e604–e8 doi:10.1016/j.wneu.2018.11.232 pmid:30529522
    CrossRefPubMed
  14. 14.↵
    1. Kaesmacher J,
    2. Meinel TR,
    3. Kurmann C, et al
    . Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy: a systematic review and meta-analysis of observational data. J Neurointerv Surg 2021 Jan 29. [Epub ahead of print] doi:10.1136/neurintsurg-2020-016680 pmid:33514609
    Abstract/FREE Full Text
  15. 15.↵
    1. Yoon W,
    2. Jung MY,
    3. Jung SH, et al
    . Subarachnoid hemorrhage in a multimodal approach heavily weighted toward mechanical thrombectomy with Solitaire stent in acute stroke. Stroke 2013;44:414–19 doi:10.1161/STROKEAHA.112.675546 pmid:23287788
    Abstract/FREE Full Text
  16. 16.↵
    1. Turk AS,
    2. Frei D,
    3. Fiorella D, et al
    . ADAPT FAST study: a direct aspiration first pass technique for acute stroke thrombectomy. J Neurointerv Surg 2014;6:260–64 doi:10.1136/neurintsurg-2014-011125 pmid:24569575
    Abstract/FREE Full Text
  17. 17.↵
    1. Hacke W,
    2. Kaste M,
    3. Fieschi C, et al
    . Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II): Second European-Australasian Acute Stroke Study Investigators. Lancet 1998;352:1245–51 doi:10.1016/S0140-6736(98)08020-9 pmid:9788453
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Furlan A,
    2. Higashida R,
    3. Wechsler L, et al
    . Intra-arterial prourokinase for acute ischemic stroke: the PROACT II study: a randomized controlled trial—Prolyse in Acute Cerebral Thromboembolism. JAMA 1999;282:2003–11 doi:10.1001/jama.282.21.2003 pmid:10591382
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Lee YB,
    2. Yoon W,
    3. Lee YY, et al
    . Predictors and impact of hemorrhagic transformations after endovascular thrombectomy in patients with acute large vessel occlusions. J Neurointerv Surg 2019;11:469–73 doi:10.1136/neurintsurg-2018-014080 pmid:30291207
    Abstract/FREE Full Text
  20. 20.↵
    1. Tonetti DA,
    2. Desai SM,
    3. Casillo S, et al
    . Successful reperfusion, rather than number of passes, predicts clinical outcome after mechanical thrombectomy. J Neurointerv Surg 2020;12:548–51 doi:10.1136/neurintsurg-2019-015330 pmid:31676689
    Abstract/FREE Full Text
  21. 21.↵
    1. Aydin K,
    2. Barburoglu M,
    3. Oztop Cakmak O, et al
    . Crossing Y-Solitaire thrombectomy as a rescue treatment for refractory acute occlusions of the middle cerebral artery. J Neurointerv Surg 2019;11:246–50 doi:10.1136/neurintsurg-2018-014288 pmid:30194110
    Abstract/FREE Full Text
  22. 22.↵
    1. Crosa R,
    2. Spiotta AM,
    3. Negrotto M, et al
    . “Y-stent retriever”: a new rescue technique for refractory large-vessel occlusions? J Neurosurg 2018;128:1349–53 doi:10.3171/2016.12.JNS161233 pmid:28524799
    CrossRefPubMed
  23. 23.↵
    1. Chang Y,
    2. Kim BM,
    3. Bang OY, et al
    . Rescue stenting for failed mechanical thrombectomy in acute ischemic stroke: a multicenter experience. Stroke 2018;49:958–64 doi:10.1161/STROKEAHA.117.020072 pmid:29581342
    Abstract/FREE Full Text
  24. 24.↵
    1. Fischer U,
    2. Kaesmacher J,
    3. Molina CA, et al
    . Primary thrombectomy in tPA (tissue-type plasminogen activator) eligible stroke patients with proximal intracranial occlusions. Stroke 2018;49:265–69 doi:10.1161/STROKEAHA.117.018564 pmid:29212747
    FREE Full Text
  25. 25.↵
    1. del Zoppo GJ,
    2. Pessin MS,
    3. Mori E, et al
    . Thrombolytic intervention in acute thrombotic and embolic stroke. Semin Neurol 1991;11:368–84 doi:10.1055/s-2008-1041241 pmid:1811293
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Gunning GM,
    2. McArdle K,
    3. Mirza M, et al
    . Clot friction variation with fibrin content; implications for resistance to thrombectomy. J Neurointerv Surg 2018;10:34–38 doi:10.1136/neurintsurg-2016-012721 pmid:28044009
    Abstract/FREE Full Text
  27. 27.↵
    1. Staessens S,
    2. Denorme F,
    3. Francois O, et al
    . Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance. Haematologica 2020;105:498–507 doi:10.3324/haematol.2019.219881 pmid:31048352
    Abstract/FREE Full Text
  28. 28.↵
    1. Navi BB,
    2. Reiner AS,
    3. Kamel H, et al
    . Risk of arterial thromboembolism in patients with cancer. J Am Coll Cardiol 2017;70:926–38 doi:10.1016/j.jacc.2017.06.047 pmid:28818202
    FREE Full Text
  29. 29.↵
    1. Baek JH,
    2. Kim BM,
    3. Heo JH, et al
    . Number of stent retriever passes associated with futile recanalization in acute stroke. Stroke 2018;49:2088–95 doi:10.1161/STROKEAHA.118.021320 pmid:30354993
    CrossRefPubMed
  30. 30.↵
    1. Filioglo A,
    2. Cohen JE,
    3. Honig A, et al
    . More than five stentriever passes: real benefit or futile recanalization? Neuroradiology 2020;62:1335–40 doi:10.1007/s00234-020-02469-x pmid:32556423
    CrossRefPubMed
  31. 31.
    1. Adams HP, Jr.,
    2. Bendixen BH,
    3. Kappelle LJ, et al
    . Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of org 10172 in Acute Stroke Treatment. Stroke 1993;24:35–41 doi:10.1161/01.str.24.1.35 pmid:7678184
    Abstract/FREE Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 42 (11)
American Journal of Neuroradiology
Vol. 42, Issue 11
1 Nov 2021
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Local Intra-arterial Thrombolysis during Mechanical Thrombectomy for Refractory Large-Vessel Occlusion: Adjunctive Chemical Enhancer of Thrombectomy
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
S.H. Baik, C. Jung, J.Y. Kim, D.-W. Shin, B.J. Kim, J. Kang, H.-J. Bae, J.H. Kim
Local Intra-arterial Thrombolysis during Mechanical Thrombectomy for Refractory Large-Vessel Occlusion: Adjunctive Chemical Enhancer of Thrombectomy
American Journal of Neuroradiology Nov 2021, 42 (11) 1986-1992; DOI: 10.3174/ajnr.A7264

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Local Intra-arterial Thrombolysis during Mechanical Thrombectomy for Refractory Large-Vessel Occlusion: Adjunctive Chemical Enhancer of Thrombectomy
S.H. Baik, C. Jung, J.Y. Kim, D.-W. Shin, B.J. Kim, J. Kang, H.-J. Bae, J.H. Kim
American Journal of Neuroradiology Nov 2021, 42 (11) 1986-1992; DOI: 10.3174/ajnr.A7264
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Comparison of combined intravenous and intra-arterial thrombolysis with intravenous thrombolysis alone in stroke patients undergoing mechanical thrombectomy: a propensity-matched analysis
  • Evaluating Thrombectomy Devices and Combination Therapies in Acute ischemic Stroke: A systematic review & Network Meta-Analysis of 201 studies
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Rescue Reentry in Carotid Near-Occlusion
  • Contour Neurovascular System: Five Year Follow Up
  • Effect of SARS-CoV2 on Endovascular Thrombectomy
Show more Neurointervention

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire