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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention

Brazilian FRED Registry: A Prospective Multicenter Study for Brain Aneurysm Treatment—The BRED Study

L.B. Manzato, R.B. Santos, P.M.M. Filho, G. Miotto, A.M. Bastos and J.R. Vanzin
American Journal of Neuroradiology October 2021, 42 (10) 1822-1826; DOI: https://doi.org/10.3174/ajnr.A7258
L.B. Manzato
aFrom the Department of Interventional Neuroradiology (L.B.M., P.M.M.F., G.M., J.R.V.), Neurology and Neurosurgery Service, Clinicas Hospital of Passo Fundo, Passo Fundo, Rio Grande do Sul, Brazil
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R.B. Santos
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P.M.M. Filho
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G. Miotto
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A.M. Bastos
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J.R. Vanzin
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    Table 1:

    Aneurysm characteristics (n = 131)a

    VariableFrequency
    Location
        Trunk125 (95.4%)
        Bifurcation6 (4.6%)
        Branch arising from the sac49 (37.4%)
    Topography
        Cavernous ICA13 (9.9%)
        Ophthalmic ICA89 (67,9%)
        Communicating ICA20 (15,2%)
        Carotid bifurcation2 (1.4%)
        AcomA3 (2.2%)
        MCA1 (0.7%)
        Basilar artery1 (0.7%)
        Vertebral artery2 (1.4%)
    Size
        Small118 (90.1%)
        Large13 (9.9%)
    Large neck
        No9 (6.9%)
        Yes122 (93.1%)
    Rupture etiology1 (0.7%)
        Saccular130 (99.3%)
        Dissecting1 (0.7%)
    Prior treatment4 (3%)
    • Note:—AcomA indicates anterior communicating artery; ICA, internal carotid artery; MCA, middle cerebral artery.

    • ↵a Values expressed as absolute and relative frequency.

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    Table 2:

    Treatment (n = 131)a

    VariableFrequency
    Use of coils12 (9.2%)
    Angioplasty5 (4.6%)
    Antiplatelet (aspirin +)
        Clopidogrel11 (8.4%)
        Prasugrel89 (67.9%)
    Complications5 (4.6%)
    Occlusion at 6 mob116 (91.3%)
    Occlusion at 12 moc117 (95.9%)
    • ↵a Values expressed as absolute and relative frequencies.

    • ↵b n = 127.

    • ↵c n = 122.

    • View popup
    Table 3:

    Univariate predictors of nonocclusion at 6 months (n = 127) and 12 months (n = 122)

    6 Months12 Months
    OR (95% CI)POR (95% CI)P
    Male sex2.36 (0.5–12.5).3457.13 (1.1–47.8).065
    Agea2.61 (1.2–5.7).0041.47 (0.6–53.4).340
    Bifurcation6.22 (1.0–538.7).0787.06 (0.6–578.4).172
    Branch vessel aneurysm3.20 (0.9–511.6).069–.002
    Coil–.130–.304
    Large aneurysm2.12 (0.4–511.1).402–.304
    Large neck–.139–.437
    Postangioplasty restenosis–.389–.558
    Clopidogrelb2.01 (0.6–57.0).2820.52 (0.1–5 4.8).542
    • Note:—Data express odds ratio (95% confidence interval). P, probability value; –, analysis not performed due to insufficient number of events.

    • ↵a For every 10 years.

    • ↵b Versus prasugrel.

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American Journal of Neuroradiology: 42 (10)
American Journal of Neuroradiology
Vol. 42, Issue 10
1 Oct 2021
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L.B. Manzato, R.B. Santos, P.M.M. Filho, G. Miotto, A.M. Bastos, J.R. Vanzin
Brazilian FRED Registry: A Prospective Multicenter Study for Brain Aneurysm Treatment—The BRED Study
American Journal of Neuroradiology Oct 2021, 42 (10) 1822-1826; DOI: 10.3174/ajnr.A7258

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Brazilian FRED Registry: A Prospective Multicenter Study for Brain Aneurysm Treatment—The BRED Study
L.B. Manzato, R.B. Santos, P.M.M. Filho, G. Miotto, A.M. Bastos, J.R. Vanzin
American Journal of Neuroradiology Oct 2021, 42 (10) 1822-1826; DOI: 10.3174/ajnr.A7258
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