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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleExtracranial Vascular
Open Access

Intraluminal Carotid Artery Thrombus in COVID-19: Another Danger of Cytokine Storm?

A.Y. Mohamud, B. Griffith, M. Rehman, D. Miller, A. Chebl, S.C. Patel, B. Howell, M. Kole and H. Marin
American Journal of Neuroradiology September 2020, 41 (9) 1677-1682; DOI: https://doi.org/10.3174/ajnr.A6674
A.Y. Mohamud
aFrom the Departments of Neurology (A.Y.M., M.R., D.M., A.C., B.H.)
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B. Griffith
bRadiology (B.G., S.C.P., H.M.)
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M. Rehman
aFrom the Departments of Neurology (A.Y.M., M.R., D.M., A.C., B.H.)
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D. Miller
aFrom the Departments of Neurology (A.Y.M., M.R., D.M., A.C., B.H.)
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A. Chebl
aFrom the Departments of Neurology (A.Y.M., M.R., D.M., A.C., B.H.)
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S.C. Patel
bRadiology (B.G., S.C.P., H.M.)
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B. Howell
aFrom the Departments of Neurology (A.Y.M., M.R., D.M., A.C., B.H.)
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M. Kole
cNeurosurgery (M.K.), Henry Ford Health System, Detroit, Michigan.
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H. Marin
bRadiology (B.G., S.C.P., H.M.)
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    FIG 1.

    Patient 1. A 55-year-old man with COVID-19 and an NIHSS score of 24. A and B, Coronal reformatted and axial images from CT angiography of the head and neck demonstrate an irregular plaque at the left internal carotid artery bifurcation (arrowhead) and nonopacification of the high cervical and petrous (short arrow) left internal carotid artery from tandem occlusion, with reconstitution of the supraclinoid segment (long arrow). C, CT angiography 3 years prior shows moderate focal stenosis of the left paraclinoid ICA (white arrow). D, CT perfusion map shows a large volume of hypoperfusion (time-to-maximum > 6 seconds) involving the left anterior and middle cerebral artery territory and a considerably smaller volume of presumed core infarct (CBF of <30%) in the left parietal region. E, Digital subtraction angiography of the left internal carotid artery demonstrates an eccentric filling defect of the left carotid bifurcation (black arrow) and left ICA occlusion, with recanalization at the level of the left ophthalmic artery from external-to-internal carotid collaterals (double black arrow).

  • FIG 2.
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    FIG 2.

    Patient 2. A 78-year-old woman with COVID-19 and an NIHSS score of 25. A, CT of the head without contrast demonstrates an evolving ischemic infarct in the left frontoparietal paracentral cortex (dotted circle) with a smaller infarct posteriorly in the left parietal cortex. B–D, Axial, coronal, and curved reformatted images from CT angiography of the head and neck demonstrate an irregular plaque at the left internal carotid artery bifurcation and an intraluminal filling defect (arrow) extending superiorly in the left internal carotid artery, corresponding to ruptured plaque with clot formation.

  • FIG 3.
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    FIG 3.

    Patient 6. A 67-year-old man presenting with fever and sudden loss of consciousness. A, Axial noncontrast CT of the head demonstrates a hyperdense left MCA branch (arrow) without evidence of acute infarct. B and C, Axial and curved reformatted images from CT angiography of the head and neck demonstrate an intraluminal clot projecting into the left internal carotid artery at the bifurcation (arrows). D, Coronal MIP from CT angiography of the head and neck demonstrates occlusion of the M1 segment of the left MCA. E, Digital subtraction angiography of the left internal carotid artery demonstrates an eccentric filling defect of the left carotid bifurcation (black arrow).

Tables

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  • Patient demographics and stroke clinical details

    Pt. No.Age (yr)SexDays from COVID-19 Sx OnsetInitial NIHSSCervical Occlusion or Near-Occlusion LocationCranial Occlusion LocationAtherosclerotic Plaque LocationTICI ScoremRSLOS (days)
    155M024Left ICA bifurcationLeft ICA petrous segmentL petrous ICA2a48
    278F1225Left ICA bifurcationNoneCarotid bulbNA518
    362M025Right ICA bifurcationRight M1Carotid bulbNA518
    474M145Right ICA bifurcationNoneCarotid bulbNA28
    559M41Right ICA bifurcationRight M2NoneNA12
    667M730Left ICA bifurcationLeft M1Carotid bulb2b412
    • Note:—Pt. indicates patient; Sx, symptom; LOS, length of stay; NA, not applicable.

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American Journal of Neuroradiology: 41 (9)
American Journal of Neuroradiology
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1 Sep 2020
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A.Y. Mohamud, B. Griffith, M. Rehman, D. Miller, A. Chebl, S.C. Patel, B. Howell, M. Kole, H. Marin
Intraluminal Carotid Artery Thrombus in COVID-19: Another Danger of Cytokine Storm?
American Journal of Neuroradiology Sep 2020, 41 (9) 1677-1682; DOI: 10.3174/ajnr.A6674

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Intraluminal Carotid Artery Thrombus in COVID-19: Another Danger of Cytokine Storm?
A.Y. Mohamud, B. Griffith, M. Rehman, D. Miller, A. Chebl, S.C. Patel, B. Howell, M. Kole, H. Marin
American Journal of Neuroradiology Sep 2020, 41 (9) 1677-1682; DOI: 10.3174/ajnr.A6674
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  • Proximal Vertebral Artery Variants and Embryology
  • High-Risk Plaque Features in Carotid MRI
  • Nonstenotic Carotid Plaques and Stroke Review
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