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Research ArticleNeurointervention

Fusion Image Guidance for Supra-Aortic Vessel Catheterization in Neurointerventions: A Feasibility Study

A. Feddal, S. Escalard, F. Delvoye, R. Fahed, J.P. Desilles, K. Zuber, H. Redjem, J.S. Savatovsky, G. Ciccio, S. Smajda, M. Ben Maacha, M. Mazighi, M. Piotin and R. Blanc
American Journal of Neuroradiology September 2020, 41 (9) 1663-1669; DOI: https://doi.org/10.3174/ajnr.A6707
A. Feddal
aFrom the Interventional Neuroradiology Unit (A.F., S.E., F.D., R.F., J.P.D., K.Z., H.R., G.C., S.S., M.B.M., M.M., M.P., R.B.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
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S. Escalard
aFrom the Interventional Neuroradiology Unit (A.F., S.E., F.D., R.F., J.P.D., K.Z., H.R., G.C., S.S., M.B.M., M.M., M.P., R.B.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
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F. Delvoye
aFrom the Interventional Neuroradiology Unit (A.F., S.E., F.D., R.F., J.P.D., K.Z., H.R., G.C., S.S., M.B.M., M.M., M.P., R.B.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
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R. Fahed
aFrom the Interventional Neuroradiology Unit (A.F., S.E., F.D., R.F., J.P.D., K.Z., H.R., G.C., S.S., M.B.M., M.M., M.P., R.B.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
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J.P. Desilles
aFrom the Interventional Neuroradiology Unit (A.F., S.E., F.D., R.F., J.P.D., K.Z., H.R., G.C., S.S., M.B.M., M.M., M.P., R.B.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
bUniversité Paris Denis Diderot (J.P.D., M.M., M.P., R.B.), Sorbonne Paris Cite, Paris, France
cLaboratory of Vascular Translational Science (J.P.D., M.M., M.P., R.B.), U1148 Institut National de la Santé et de la Recherche Médicale, Paris, France
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K. Zuber
aFrom the Interventional Neuroradiology Unit (A.F., S.E., F.D., R.F., J.P.D., K.Z., H.R., G.C., S.S., M.B.M., M.M., M.P., R.B.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
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H. Redjem
aFrom the Interventional Neuroradiology Unit (A.F., S.E., F.D., R.F., J.P.D., K.Z., H.R., G.C., S.S., M.B.M., M.M., M.P., R.B.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
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J.S. Savatovsky
dDiagnostic Neuroradiology Unit (J.S.S.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
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G. Ciccio
aFrom the Interventional Neuroradiology Unit (A.F., S.E., F.D., R.F., J.P.D., K.Z., H.R., G.C., S.S., M.B.M., M.M., M.P., R.B.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
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S. Smajda
aFrom the Interventional Neuroradiology Unit (A.F., S.E., F.D., R.F., J.P.D., K.Z., H.R., G.C., S.S., M.B.M., M.M., M.P., R.B.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
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M. Ben Maacha
aFrom the Interventional Neuroradiology Unit (A.F., S.E., F.D., R.F., J.P.D., K.Z., H.R., G.C., S.S., M.B.M., M.M., M.P., R.B.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
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M. Mazighi
aFrom the Interventional Neuroradiology Unit (A.F., S.E., F.D., R.F., J.P.D., K.Z., H.R., G.C., S.S., M.B.M., M.M., M.P., R.B.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
bUniversité Paris Denis Diderot (J.P.D., M.M., M.P., R.B.), Sorbonne Paris Cite, Paris, France
cLaboratory of Vascular Translational Science (J.P.D., M.M., M.P., R.B.), U1148 Institut National de la Santé et de la Recherche Médicale, Paris, France
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M. Piotin
aFrom the Interventional Neuroradiology Unit (A.F., S.E., F.D., R.F., J.P.D., K.Z., H.R., G.C., S.S., M.B.M., M.M., M.P., R.B.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
bUniversité Paris Denis Diderot (J.P.D., M.M., M.P., R.B.), Sorbonne Paris Cite, Paris, France
cLaboratory of Vascular Translational Science (J.P.D., M.M., M.P., R.B.), U1148 Institut National de la Santé et de la Recherche Médicale, Paris, France
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R. Blanc
aFrom the Interventional Neuroradiology Unit (A.F., S.E., F.D., R.F., J.P.D., K.Z., H.R., G.C., S.S., M.B.M., M.M., M.P., R.B.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
bUniversité Paris Denis Diderot (J.P.D., M.M., M.P., R.B.), Sorbonne Paris Cite, Paris, France
cLaboratory of Vascular Translational Science (J.P.D., M.M., M.P., R.B.), U1148 Institut National de la Santé et de la Recherche Médicale, Paris, France
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    FIG 1.

    Example of a virtual roadmap of supra-aortic vessels. The vasculature is segmented from the MRA dataset with VesselNavigator software, with landmarks added on the brachiocephalic artery trunk, the right and left common carotid arteries, and the left subclavian artery. During this step, the operator saves projection angles, which can be recalled during catheterization.

  • FIG 2.
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    FIG 2.

    Detailed workflow of the MRA-fluoroscopy or CTA-fluoroscopy image fusion process for supra-aortic vessel catheterization in neurovascular interventions. Preoperative planning starts with uploading the MRA/CTA dataset on VesselNavigator. A, 3D semiautomatic segmentation of the aortic arch and the supra-aortic vessels and ostium labeling. B, Perioperative 2D–3D coregistration with 2 orthogonal positions of the anterior-posterior C-arm using anatomic landmarks. C, Perioperative augmented guidance.

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    FIG 3.

    Spatial accuracy assessment of MRA/CTA–fluoroscopy fusion. A 3-category semiquantitative scale was used to measure the maximum offset. A, Example of an accurate fusion at the ostium of the brachiocephalic artery trunk: The catheter projects within the lumen of the vessel in the ROI. B, Example of a mismatch at the ostium of the right common carotid artery: The catheter projects out of the lumen but within a distance inferior to the diameter of the vessel. C, Example of an inaccurate fusion at the ostium of the left common carotid artery: The catheter projects out of the vessel at a distance superior to the diameter.

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    Table 1:

    Patient characteristics (demographics, cardiovascular risk, procedure features, and aortic arch type)

    Patient Characteristics
    Age (yr)
        Median (Interquartile range)55 (50–68)
    Sex
        Female (No.) (%)20 (61%)
        Male (No.) (%)13 (39%)
    Cardiovascular risk factorsa (No.) (%)
        012 (34%)
        16 (16%)
        ≥217 (50%)
    Procedure type (No.) (%)
        Diagnostic/follow-up angiography23 (66%)
        Intracranial embolization9 (16%)
        Mechanical thrombectomy3 (8%)
    Anesthesia (No.) (%)
        Conscious sedation26 (74%)
        General anesthesia9 (26%)
    Noninvasive imaging for navigation (No.) (%)
        CTA12 (34%)
        MRA23 (66%)
    Aortic arch type (No.) (%)
        I20 (57%)
        II8 (23%)
        III7 (20%)
        Bovine variant9 (26%)
    • ↵a We considered smoking, high blood pressure, high low-density lipoprotein and low high-density lipoprotein cholesterol levels, age, and obesity.

    • View popup
    Table 2:

    Spatial accuracy assessment of the virtual 3D roadmap for the 9 ROIs

    ROIs of the Virtual Roadmap/Spatial AccuracyNo. (%)
    Brachiocephalic artery trunk
        Accurate27 (96.4)
        Mismatch1 (3.6)
        Inaccurate
        All28 (100)
    Right subclavian artery
        Accurate8 (100)
        Mismatch
        Inaccurate
        All8 (100)
    Right vertebral artery
        Accurate5 (100)
        Mismatch
        Inaccurate
        All5 (100)
    Right common carotid artery
        Accurate16 (69.6)
        Mismatch3 (13.0)
        Inaccurate4 (17.4)
        All23 (100)
    Right internal carotid artery
        Accurate10 (66.7)
        Mismatch3 (20.0)
        Inaccurate2 (13.3)
        All15 (100)
    Left common carotid artery
        Accurate24 (85.7)
        Mismatch3 (10.7)
        Inaccurate1 (3.6)
        All28 (100)
    Left internal carotid artery
        Accurate17 (81.0)
        Mismatch3 (14.3)
        Inaccurate1 (4.8)
        All21 (100)
    Left subclavian artery
        Accurate13 (92.9)
        Mismatch1 (7.1)
        Inaccurate
        All14 (100)
    Left vertebral artery
        Accurate8 (88.9)
        Mismatch1 (11.1)
        Inaccurate
        All9 (100)
    Overall
        Accurate128 (84.8)
        Mismatch15 (9.9)
        Inaccurate8 (5.3)
        All
    • View popup
    Table 3:

    Comparison of spatial accuracy between aortic arch and cervical level (group 1) and the distal cervical level (group 2)

    Spatial AccuracyGroup 1 No. (%)Group 2 No. (%)Overall No. (%)
    Accurate85 (92.4)43 (72.9)128 (84.8)
    Mismatch/inaccurate7 (7.6)16 (27.1)23 (15.2)
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A. Feddal, S. Escalard, F. Delvoye, R. Fahed, J.P. Desilles, K. Zuber, H. Redjem, J.S. Savatovsky, G. Ciccio, S. Smajda, M. Ben Maacha, M. Mazighi, M. Piotin, R. Blanc
Fusion Image Guidance for Supra-Aortic Vessel Catheterization in Neurointerventions: A Feasibility Study
American Journal of Neuroradiology Sep 2020, 41 (9) 1663-1669; DOI: 10.3174/ajnr.A6707

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Fusion Image Guidance for Supra-Aortic Vessel Catheterization in Neurointerventions: A Feasibility Study
A. Feddal, S. Escalard, F. Delvoye, R. Fahed, J.P. Desilles, K. Zuber, H. Redjem, J.S. Savatovsky, G. Ciccio, S. Smajda, M. Ben Maacha, M. Mazighi, M. Piotin, R. Blanc
American Journal of Neuroradiology Sep 2020, 41 (9) 1663-1669; DOI: 10.3174/ajnr.A6707
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