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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Review ArticleNeurointervention
Open Access

Tandem Carotid Lesions in Acute Ischemic Stroke: Mechanisms, Therapeutic Challenges, and Future Directions

A.Y. Poppe, G. Jacquin, D. Roy, C. Stapf and L. Derex
American Journal of Neuroradiology July 2020, 41 (7) 1142-1148; DOI: https://doi.org/10.3174/ajnr.A6582
A.Y. Poppe
aFrom the Departments of Medicine (Neurology) (A.Y.P., G.J., C.S.)
cNeurovascular Group (A.Y.P., G.J., C.S.), Axe Neurosciences, Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montréal, Québec, Canada
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G. Jacquin
aFrom the Departments of Medicine (Neurology) (A.Y.P., G.J., C.S.)
cNeurovascular Group (A.Y.P., G.J., C.S.), Axe Neurosciences, Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montréal, Québec, Canada
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D. Roy
bRadiology (Neuroradiology) (D.R.), Centre Hospitalier de l’Université de Montréal, Montréal, Québec, Canada
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C. Stapf
aFrom the Departments of Medicine (Neurology) (A.Y.P., G.J., C.S.)
cNeurovascular Group (A.Y.P., G.J., C.S.), Axe Neurosciences, Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Montréal, Québec, Canada
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L. Derex
dStroke Center (L.D.), Department of Neurology, Neurological Hospital, Hospices Civils de Lyon, Lyon, France
eEA 7425 HESPER (L.D.), Health Services and Performance Research, Claude Bernard Lyon 1 University, Lyon, France.
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References

  1. 1.↵
    1. Jadhav AP,
    2. Zaidat OO,
    3. Liebeskind DS, et al
    . Emergent management of tandem lesions in acute ischemic stroke. Stroke 2019;50:428–33 doi:10.1161/STROKEAHA.118.021893 pmid:30580729
    CrossRefPubMed
  2. 2.↵
    1. Papanagiotou P,
    2. Haussen DC,
    3. Turjman F, et al
    ; TITAN Investigators. Carotid stenting with antithrombotic agents and intracranial thrombectomy leads to the highest recanalization rate in patients with acute stroke with tandem lesions. JACC Cardiovasc Interv 2018;11:1290–99 doi:10.1016/j.jcin.2018.05.036 pmid:29976365
    Abstract/FREE Full Text
  3. 3.↵
    1. Rockman CB,
    2. Hoang H,
    3. Guo Y, et al
    . The prevalence of carotid artery stenosis varies significantly by race. J Vasc Surg 2013;57:327–37 doi:10.1016/j.jvs.2012.08.118 pmid:23177534
    CrossRefPubMed
  4. 4.↵
    1. Kim YS,
    2. Garami Z,
    3. Mikulik R, et al
    . Early recanalization rates and clinical outcomes in patients with tandem internal carotid artery/middle cerebral artery occlusion and isolated middle cerebral artery occlusion. Stroke 2005;36:869–71 doi:10.1161/01.STR.0000160007.57787.4c pmid:15746449
    Abstract/FREE Full Text
  5. 5.↵
    1. Powers WJ,
    2. Rabinstein AA,
    3. Ackerson T, et al
    . Guidelines for the Early Management of Patients with Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke—A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 2019;50:e344–418 doi:10.1161/STR.0000000000000211 pmid:31662037
    CrossRefPubMed
  6. 6.↵
    1. Turc G,
    2. Bhogal P,
    3. Fischer U, et al
    . European Stroke Organisation (ESO)–European Society for Minimally Invasive Neurological Therapy (ESMINT) Guidelines on Mechanical Thrombectomy in Acute Ischaemic Stroke Endorsed by Stroke Alliance for Europe (SAFE). Eur Stroke J 2019;4:6–12 doi:10.1177/2396987319832140 pmid:31165090
    CrossRefPubMed
  7. 7.↵
    1. Gory B,
    2. Piotin M,
    3. Haussen DC, et al
    ; TITAN Investigators. Thrombectomy in acute stroke with tandem occlusions from dissection versus atherosclerotic cause. Stroke 2017;48:3145–48 doi:10.1161/STROKEAHA.117.018264 pmid:28974628
    Abstract/FREE Full Text
  8. 8.↵
    1. Provenzale JM,
    2. Sarikaya B
    . Comparison of test performance characteristics of MRI, MR angiography, and CT angiography in the diagnosis of carotid and vertebral artery dissection: a review of the medical literature. AJR Am J Roentgenol 2009;193:1167–74 doi:10.2214/AJR.08.1688 pmid:19770343
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Downer J,
    2. Nadarajah M,
    3. Briggs E, et al
    . The location of origin of spontaneous extracranial internal carotid artery dissection is adjacent to the skull base. J Med Imaging Radiat Oncol 2014;58:408–14 doi:10.1111/1754-9485.12170 pmid:24602260
    CrossRefPubMed
  10. 10.↵
    1. Lee VH,
    2. Brown RD Jr.,
    3. Mandrekar JN, et al
    . Incidence and outcome of cervical artery dissection: a population-based study. Neurology 2006;67:1809–12 doi:10.1212/01.wnl.0000244486.30455.71 pmid:17130413
    Abstract/FREE Full Text
  11. 11.↵
    1. Jacquin G,
    2. Poppe AY,
    3. Labrie M, et al
    . Lack of consensus among stroke experts on the optimal management of patients with acute tandem occlusion. Stroke 2019;50:1254–56 doi:10.1161/STROKEAHA.118.023758 pmid:30890115
    CrossRefPubMed
  12. 12.↵
    1. Marnat G,
    2. Buhlmann M,
    3. Eker OF, et al
    . Multicentric experience in distal-to-proximal revascularization of tandem occlusion stroke related to internal carotid artery dissection. AJNR Am J Neuroradiol 2018;39:1093–99 doi:10.3174/ajnr.A5640 pmid:29700047
    Abstract/FREE Full Text
  13. 13.↵
    1. Baracchini C,
    2. Tonello S,
    3. Meneghetti G, et al
    . Neurosonographic monitoring of 105 spontaneous cervical artery dissections: a prospective study. Neurology 2010;75:1864–70 doi:10.1212/WNL.0b013e3181feae5e pmid:20962286
    Abstract/FREE Full Text
  14. 14.↵
    1. Gliem M,
    2. Lee JI,
    3. Barckhan A, et al
    . Outcome and treatment effects in stroke associated with acute cervical ICA occlusion. PLoS One 2017;12:e0170247 doi:10.1371/journal.pone.0170247 pmid:28081270
    CrossRefPubMed
  15. 15.↵
    1. Eker OF,
    2. Panni P,
    3. Dargazanli C, et al
    . Anterior circulation acute ischemic stroke associated with atherosclerotic lesions of the cervical ICA: a nosologic entity apart. AJNR Am J Neuroradiol 2017;38:2138–45 doi:10.3174/ajnr.A5404 pmid:29051203
    Abstract/FREE Full Text
  16. 16.↵
    1. Anadani M,
    2. Spiotta A,
    3. Alawieh A, et al
    ; TITAN (Thrombectomy In TANdem Lesions) Investigators. Effect of extracranial lesion severity on outcome of endovascular thrombectomy in patients with anterior circulation tandem occlusion: analysis of the TITAN registry. J Neurointerv Surg 2019;11:970–74 doi:10.1136/neurintsurg-2018-014629 pmid:30842304
    Abstract/FREE Full Text
  17. 17.↵
    1. Grossberg JA,
    2. Haussen DC,
    3. Cardoso FB, et al
    . Cervical carotid pseudo-occlusions and false dissections: intracranial occlusions masquerading as extracranial occlusions. Stroke 2017;48:774–77 doi:10.1161/STROKEAHA.116.015427 pmid:28119435
    Abstract/FREE Full Text
  18. 18.↵
    1. Kappelhof M,
    2. Marquering HA,
    3. Berkhemer OA, et al
    ; MR CLEAN Investigators. Accuracy of CT angiography for differentiating pseudo-occlusion from true occlusion or high-grade stenosis of the extracranial ICA in acute ischemic stroke: a retrospective MR CLEAN substudy. AJNR Am J Neuroradiol 2018;39:892–98 doi:10.3174/ajnr.A5601 pmid:29622556
    Abstract/FREE Full Text
  19. 19.↵
    1. Volders D,
    2. Shewchuk JR,
    3. Marangoni M, et al
    . Beyond the collaterals: additional value of multiphase CTA in acute ischemic stroke evaluation. Neuroradiol J 2019;32:309–14 doi:10.1177/1971400919845361 pmid:31018761
    CrossRefPubMed
  20. 20.↵
    1. Sivan-Hoffmann R,
    2. Gory B,
    3. Armoiry X, et al
    . Stent-retriever thrombectomy for acute anterior ischemic stroke with tandem occlusion: a systematic review and meta-analysis. Eur Radiol 2017;27:247–54 doi:10.1007/s00330-016-4338-y pmid:27085698
    CrossRefPubMed
  21. 21.↵
    1. Wallocha M,
    2. Chapot R,
    3. Nordmeyer H, et al
    . Treatment methods and early neurologic improvement after endovascular treatment of tandem occlusions in acute ischemic stroke. Front Neurol 2019;10:127 doi:10.3389/fneur.2019.00127 pmid:30873105
    CrossRefPubMed
  22. 22.↵
    1. Heck DV,
    2. Brown MD
    . Carotid stenting and intracranial thrombectomy for treatment of acute stroke due to tandem occlusions with aggressive antiplatelet therapy may be associated with a high incidence of intracranial hemorrhage. J Neurointerv Surg 2015;7:170–75 doi:10.1136/neurintsurg-2014-011224 pmid:25387730
    Abstract/FREE Full Text
  23. 23.↵
    1. Zhu F,
    2. Labreuche J,
    3. Haussen DC, et al
    ; TITAN (Thrombectomy in Tandem Lesions) Investigators. Hemorrhagic transformation after thrombectomy for tandem occlusions. Stroke 2019;50:516–19 doi:10.1161/STROKEAHA.118.023689 pmid:30580731
    CrossRefPubMed
  24. 24.↵
    1. Pop R,
    2. Zinchenko I,
    3. Quenardelle V, et al
    . Predictors and clinical impact of delayed stent thrombosis after thrombectomy for acute stroke with tandem lesions. AJNR Am J Neuroradiol 2019;40:533–39 doi:10.3174/ajnr.A5976 pmid:30765378
    Abstract/FREE Full Text
  25. 25.↵
    1. Sadeh-Gonik U,
    2. Tau N,
    3. Friehmann T, et al
    . Thrombectomy outcomes for acute stroke patients with anterior circulation tandem lesions: a clinical registry and an update of systematic review with meta-analysis. Eur J Neurol 2018;25:693–700 doi:10.1111/ene.13577 pmid:29350803
    CrossRefPubMed
  26. 26.↵
    1. Wilson MP,
    2. Murad MH,
    3. Krings T, et al
    . Management of tandem occlusions in acute ischemic stroke: intracranial versus extracranial first and extracranial stenting versus angioplasty alone—a systematic review and meta-analysis. J Neurointerv Surg 2018;10:721–28 doi:10.1136/neurintsurg-2017-013707 pmid:29523749
    Abstract/FREE Full Text
  27. 27.↵
    1. Haussen DC,
    2. Turjman F,
    3. Piotin M, et al
    ; on behalf of the TITAN (Thrombectomy In TANdem Lesions) Investigators. Head or neck first? Speed and rates of reperfusion in thrombectomy for tandem large vessel occlusion strokes. Intervent Neurol 2019;8:92–100 doi:10.1159/000496292
    CrossRef
  28. 28.↵
    1. Lockau H,
    2. Liebig T,
    3. Henning T, et al
    . Mechanical thrombectomy in tandem occlusion: procedural considerations and clinical results. Neuroradiology 2015;57:589–98 doi:10.1007/s00234-014-1465-5 pmid:25404414
    CrossRefPubMed
  29. 29.↵
    1. Maus V,
    2. Behme D,
    3. Maurer C, et al
    . The ReWiSed CARe technique: simultaneous treatment of atherosclerotic tandem occlusions in acute ischemic stroke. Clin Neuroradiol 2019 May 22. [Epub ahead of print] doi:10.1007/s00062-019-00795-z pmid:31119326
    CrossRefPubMed
  30. 30.↵
    1. Paul AR,
    2. Entezami P,
    3. Nourollahzadeh E, et al
    . Simultaneous revascularization of the occluded internal carotid artery using the Solitaire as a workhorse wire during acute ischemic stroke intervention. Interv Neuroradiol 2020;26:205–10 doi:10.1177/1591019919885253 pmid:31696768
    CrossRefPubMed
  31. 31.↵
    1. Yilmaz U,
    2. Korner H,
    3. Muhl-Benninghaus R, et al
    . Acute occlusions of dual-layer carotid stents after endovascular emergency treatment of tandem lesions. Stroke 2017;48:2171–75 doi:10.1161/STROKEAHA.116.015965 pmid:28679854
    Abstract/FREE Full Text
  32. 32.↵
    1. Bartolini B,
    2. Puccinelli F,
    3. Mosimann PJ, et al
    . Evaluating the effectiveness and safety of the carotid Casper-RX stent for tandem lesions in acute ischemic stroke. J Neurointerv Surg 2019;11:772–74 doi:10.1136/neurintsurg-2018-014425 pmid:30514733
    Abstract/FREE Full Text
  33. 33.↵
    1. Pfaff JA,
    2. Maurer C,
    3. Broussalis E, et al
    . Acute thromboses and occlusions of dual layer carotid stents in endovascular treatment of tandem occlusions. J Neurointerv Surg 2020;12:33–37 doi:10.1136/neurintsurg-2019-015032 pmid:31308199
    Abstract/FREE Full Text
  34. 34.↵
    1. Zinkstok SM,
    2. Roos YB
    ; ARTIS investigators. Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: a randomised controlled trial. Lancet 2012;380:731–37 doi:10.1016/S0140-6736(12)60949-0 pmid:22748820
    CrossRefPubMed
  35. 35.↵
    1. Stampfl S,
    2. Ringleb PA,
    3. Mohlenbruch M, et al
    . Emergency cervical internal carotid artery stenting in combination with intracranial thrombectomy in acute stroke. AJNR Am J Neuroradiol 2014;35:741–46 doi:10.3174/ajnr.A3763 pmid:24157733
    Abstract/FREE Full Text
  36. 36.↵
    1. Anadani M,
    2. Spiotta AM,
    3. Alawieh A, et al
    ; on behalf of the TITAN (Thrombectomy In TANdem Lesions) Investigators. Emergent carotid stenting plus thrombectomy after thrombolysis in tandem strokes. Stroke 2019;50:2250–52 doi:10.1161/STROKEAHA.118.024733 pmid:31577899
    CrossRefPubMed
  37. 37.↵
    1. Gory B,
    2. Haussen DC,
    3. Piotin M, et al
    ; the Thrombectomy In TANdem lesions (TITAN) investigators. Impact of intravenous thrombolysis and emergent carotid stenting on reperfusion and clinical outcomes in patients with acute stroke with tandem lesion treated with thrombectomy: a collaborative pooled analysis. Eur J Neurol 2018;25:1115–20 doi:10.1111/ene.13633 pmid:29575634
    CrossRefPubMed
  38. 38.↵
    1. Eker OF,
    2. Buhlmann M,
    3. Dargazanli C, et al
    . Endovascular treatment of atherosclerotic tandem occlusions in anterior circulation stroke: technical aspects and complications compared to isolated intracranial occlusions. Front Neurol 2018;9:1046 doi:10.3389/fneur.2018.01046 pmid:30619028
    CrossRefPubMed
  39. 39.↵
    1. Brott TG,
    2. Hobson RW 2nd.,
    3. Howard G, et al
    ; CREST Investigators. Stenting versus endarterectomy for treatment of carotid-artery stenosis. N Engl J Med 2010;363:11–23 doi:10.1056/NEJMoa0912321 pmid:20505173
    CrossRefPubMedWeb of Science
  40. 40.↵
    1. Olafson EM,
    2. DeGrote JR,
    3. Drofa A, et al
    . A case series of 18 patients receiving ticagrelor after carotid stenting. J Pharm Pract 2018;31:519–21 doi:10.1177/0897190017729524 pmid:28877643
    CrossRefPubMed
  41. 41.↵
    1. Aguilar-Salinas P,
    2. Agnoletto GJ,
    3. Brasiliense LBC, et al
    . Safety and efficacy of cangrelor in acute stenting for the treatment of cerebrovascular pathology: preliminary experience in a single-center pilot study. J NeuroIntervent Surg 2019;11:347–51 doi:10.1136/neurintsurg-2018-014396 pmid:30552167
    Abstract/FREE Full Text
  42. 42.↵
    1. Nahab F,
    2. Kass-Hout T,
    3. Shaltoni HM
    . Periprocedural antithrombotic strategies in acute ischemic stroke interventional therapy. Neurology 2012;79:(Suppl 1)S174–81 doi:10.1212/WNL.0b013e31826959af pmid:23008395
    Abstract/FREE Full Text
  43. 43.↵
    1. Neuberger U,
    2. Moteva K,
    3. Vollherbst DF, et al
    . Tandem occlusions in acute ischemic stroke - impact of antithrombotic medication and complementary heparin on clinical outcome and stent patency. J Neurointerv Surg 2020 Jan 14. [Epub ahead of print] doi:10.1136/neurintsurg-2019-015596 pmid:31937604
    Abstract/FREE Full Text
  44. 44.↵
    1. Zhu F,
    2. Piotin M,
    3. Steglich-Arnholm H, et al
    ; TITAN (Thrombectomy In TANdem Lesions) Investigators. Periprocedural heparin during endovascular treatment of tandem lesions in patients with acute ischemic stroke: a propensity score analysis from TITAN registry. Cardiovasc Intervent Radiol 2019;42:1160–67 doi:10.1007/s00270-019-02251-4 pmid:31152229
    CrossRefPubMed
  45. 45.↵
    1. Ederle J,
    2. Featherstone RL,
    3. Brown MM
    . Percutaneous transluminal angioplasty and stenting for carotid artery stenosis. Cochrane Database Syst Rev 2007;CD000515 doi:10.1002/14651858.CD000515.pub3 pmid:17943745
    CrossRefPubMed
  46. 46.↵
    1. Assis Z,
    2. Menon BK,
    3. Goyal M, et al
    ; ESCAPE Trialists. Acute ischemic stroke with tandem lesions: technical endovascular management and clinical outcomes from the ESCAPE trial. J Neurointerv Surg 2018;10:429–33 doi:10.1136/neurintsurg-2017-013316 pmid:29021311
    Abstract/FREE Full Text
  47. 47.↵
    1. Rothwell PM,
    2. Eliasziw M,
    3. Gutnikov SA, et al
    ; Carotid Endarterectomy Trialists’ Collaboration. Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis. Lancet 2003;361:107–16 doi:10.1016/S0140-6736(03)12228-3
    CrossRefPubMedWeb of Science
  48. 48.↵
    1. Labeyrie MA,
    2. Ducroux C,
    3. Civelli V, et al
    . Endovascular management of extracranial occlusions at the hyperacute phase of stroke with tandem occlusions. J Neuroradiol 2018;45:196–201 doi:10.1016/j.neurad.2017.10.003 pmid:29132938
    CrossRefPubMed
  49. 49.↵
    EC/IC Bypass Study Group. Failure of extracranial-intracranial arterial bypass to reduce the risk of ischemic stroke: results of an international randomized trial. N Engl J Med 1985;313:1191–1200 doi:10.1056/NEJM198511073131904 pmid:2865674
    CrossRefPubMedWeb of Science
  50. 50.↵
    1. Powers WJ,
    2. Clarke WR,
    3. Grubb RL Jr., et al
    ; COSS Investigators. Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial. JAMA 2011;306:1983–92 doi:10.1001/jama.2011.1610 pmid:22068990
    CrossRefPubMedWeb of Science
  51. 51.↵
    1. Saver JL,
    2. Goyal M,
    3. Bonafe A, et al
    ; SWIFT PRIME Investigators. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med 2015;372:2285–95 doi:10.1056/NEJMoa1415061 pmid:25882376
    CrossRefPubMed
  52. 52.
    1. Campbell BC,
    2. Mitchell PJ,
    3. Kleinig TJ, et al
    ; EXTEND-IA Investigators. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med 2015;372:1009–18 doi:10.1056/NEJMoa1414792 pmid:25671797
    CrossRefPubMed
  53. 53.↵
    1. Bracard S,
    2. Ducrocq X,
    3. Mas JL, et al
    ; THRACE investigators. Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial. Lancet Neurol 2016;15:1138–47 doi:10.1016/S1474-4422(16)30177-6 pmid:27567239
    CrossRefPubMed
  54. 54.↵
    1. Goyal M,
    2. Menon BK,
    3. van Zwam WH, et al
    ; HERMES collaborators. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet 2016;387:1723–31 doi:10.1016/S0140-6736(16)00163-X pmid:26898852
    CrossRefPubMed
  55. 55.↵
    1. Nogueira RG,
    2. Jadhav AP,
    3. Haussen DC, et al
    ; DAWN Trial Investigators. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med 2018;378:11–21 doi:10.1056/NEJMoa1706442 pmid:29129157
    CrossRefPubMed
  56. 56.↵
    1. Tekle WG,
    2. Hassan AE,
    3. Jadhav AP, et al
    ; on behalf of the DAWN Trial Investigators. Impact of periprocedural and technical factors and patient characteristics on revascularization and outcome in the DAWN trial. Stroke 2020;51:247–53 doi:10.1161/STROKEAHA.119.026437 pmid:1744425
    CrossRefPubMed
  57. 57.↵
    1. Albers GW,
    2. Marks MP,
    3. Kemp S, et al
    ; DEFUSE 3 Investigators. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med 2018;378:708–18 doi:10.1056/NEJMoa1713973 pmid:29364767
    CrossRefPubMed
  58. 58.↵
    1. Marks MP,
    2. Heit JJ,
    3. Lansberg MG, et al
    ; DEFUSE 3 Investigators. Endovascular treatment in the DEFUSE 3 study. Stroke 2018;49:2000–03 doi:10.1161/STROKEAHA.118.022147 pmid:29986935
    CrossRefPubMed
  59. 59.↵
    1. Pires Coelho A,
    2. Lobo M,
    3. Gouveia R, et al
    . Overview of evidence on emergency carotid stenting in patients with acute ischemic stroke due to tandem occlusions: a systematic review and meta-analysis. J Cardiovasc Surg (Torino) 2019;60:693–702 doi:10.23736/S0021-9509.18.10312-0 pmid:29363895
    CrossRefPubMed
  60. 60.↵
    1. Khoury NN,
    2. Darsaut TE,
    3. Ghostine J, et al
    ; EASI Trial Collaborators. Endovascular thrombectomy and medical therapy versus medical therapy alone in acute stroke: a randomized care trial. J Neuroradiol 2017;44:198–202 doi:10.1016/j.neurad.2017.01.126 pmid:28238522
    CrossRefPubMed
  61. 61.↵
    1. Poppe AY,
    2. Jacquin G,
    3. Stapf C, et al
    . A randomized pilot study of patients with tandem carotid lesions undergoing thrombectomy. J Neuroradiol 2019 Sep 26. [Epub ahead of print] doi:10.1016/j.neurad.2019.08.003 pmid:31563589
    CrossRefPubMed
  62. 62.↵
    1. Poppe AY,
    2. Stapf C,
    3. Raymond J
    . Letter by Poppe et al regarding article, “Emergent Carotid Stenting After Thrombectomy in Patients With Tandem Lesions.” Stroke 2017;48:E182 doi:10.1161/STROKEAHA.117.017837 pmid:28596455
    CrossRefPubMed
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American Journal of Neuroradiology: 41 (7)
American Journal of Neuroradiology
Vol. 41, Issue 7
1 Jul 2020
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Tandem Carotid Lesions in Acute Ischemic Stroke: Mechanisms, Therapeutic Challenges, and Future Directions
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Cite this article
A.Y. Poppe, G. Jacquin, D. Roy, C. Stapf, L. Derex
Tandem Carotid Lesions in Acute Ischemic Stroke: Mechanisms, Therapeutic Challenges, and Future Directions
American Journal of Neuroradiology Jul 2020, 41 (7) 1142-1148; DOI: 10.3174/ajnr.A6582

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Tandem Carotid Lesions in Acute Ischemic Stroke: Mechanisms, Therapeutic Challenges, and Future Directions
A.Y. Poppe, G. Jacquin, D. Roy, C. Stapf, L. Derex
American Journal of Neuroradiology Jul 2020, 41 (7) 1142-1148; DOI: 10.3174/ajnr.A6582
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  • Safety of acute internal carotid artery stenting during endovascular thrombectomy in patients with acute ischemic stroke: a retrospective analysis of the OPTIMISE registry
  • Effects of Emergent Carotid Stenting Performed before or after Mechanical Thrombectomy in the Endovascular Management of Patients with Tandem Lesions: A Multicenter Retrospective Matched Analysis
  • Antithrombotic regimen in emergent carotid stenting for acute ischemic stroke due to tandem occlusion: a meta-analysis of aggregate data
  • Endovascular treatment for acute ischemic stroke in patients with tandem lesion in the anterior circulation: analysis from the METRICS study
  • Safety and Efficacy of Tenecteplase and Alteplase in Patients With Tandem Lesion Stroke: A Post Hoc Analysis of the EXTEND-IA TNK Trials
  • Antithrombotic regimen in emergent carotid stenting for acute ischemic stroke due to tandem occlusion: a meta-analysis of aggregate data
  • Management and outcome of patients with acute ischemic stroke and tandem carotid occlusion in the ESCAPE-NA1 trial
  • Endovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion
  • Proximal Internal Carotid artery Acute Stroke Secondary to tandem Occlusions (PICASSO) international survey
  • Considerations for Antiplatelet Management of Carotid Stenting in the Setting of Mechanical Thrombectomy: A Delphi Consensus Statement
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