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Research ArticlePediatric Neuroimaging

Increased Notching of the Corpus Callosum in Fetal Alcohol Spectrum Disorder: A Callosal Misunderstanding?

E. Schneble, C. Lack, M. Zapadka, C.M. Pfeifer, D.M.E. Bardo, J. Cagley, J. Acharya, A.P. Klein, M. Balla, J.T. Obayashi, D. Ross, D.R. Pettersson and J.M. Pollock
American Journal of Neuroradiology April 2020, 41 (4) 725-728; DOI: https://doi.org/10.3174/ajnr.A6475
E. Schneble
aFrom the Departments of Radiology (E.S., D.R.P., J.M.P.), and
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C. Lack
dDepartment of Radiology (C.L., M.Z.), Wake Forest University, Winston-Salem, North Carolina
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M. Zapadka
dDepartment of Radiology (C.L., M.Z.), Wake Forest University, Winston-Salem, North Carolina
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C.M. Pfeifer
eDepartment of Radiology (C.M.P.), University of Texas Southwestern Medical Center, Dallas, Texas
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D.M.E. Bardo
fDepartment of Radiology (D.M.E.B.), Phoenix Children’s Hospital, Phoenix, Arizona
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J. Cagley
gDepartment of Radiology (J.C.), Legacy Emanuel, Portland, Oregon
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J. Acharya
hDepartment of Radiology (J.A.), University of Southern California, Keck School of Medicine, Los Angeles, California
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A.P. Klein
iDepartment of Radiology (A.P.K., M.B.), Medical College of Wisconsin, Milwaukee, Wisconsin.
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M. Balla
iDepartment of Radiology (A.P.K., M.B.), Medical College of Wisconsin, Milwaukee, Wisconsin.
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J.T. Obayashi
bNeurological Surgery (J.T.O., D.R.), Oregon Health & Science University, Portland, Oregon
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D. Ross
bNeurological Surgery (J.T.O., D.R.), Oregon Health & Science University, Portland, Oregon
cOperative Care Division (D.R.), Portland Veterans Administration Hospital, Portland, Oregon
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D.R. Pettersson
aFrom the Departments of Radiology (E.S., D.R.P., J.M.P.), and
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J.M. Pollock
aFrom the Departments of Radiology (E.S., D.R.P., J.M.P.), and
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    Figure.

    Midsagittal T1-weighted images. A, A normal corpus callosum with no notch. B, A corpus callosum with anterior and posterior notches measuring 1  and 3 mm in depth (pink lines), respectively. A “notch” was defined as a depression in the dorsal surface whose depth was at least 1 mm from a tangential green line to the surface of the CC. Notches are classified as either anterior or posterior on the basis of their relationship to the midcallosal body (blue line).

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    FASDNon-FASD Control GroupFASD (Excluded Due to Structural Abnormality)
    Brain MR imaging studies reviewed (No.)5987537
    Brain MR imaging studies with notches (No.) (%)33 (55.9%)554 (63.3%)11 (29.7%)
    Posterior position (No.) (%)23 (39%)378 (43.2%)10 (27%)
    Anterior position (No.) (%)8 (13.6%)139 (15.8%)1 (2.7%)
    Undulating, >2 notches (No.) (%)2 (3.4%)37 (4.2%)0 (0%)
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American Journal of Neuroradiology: 41 (4)
American Journal of Neuroradiology
Vol. 41, Issue 4
1 Apr 2020
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E. Schneble, C. Lack, M. Zapadka, C.M. Pfeifer, D.M.E. Bardo, J. Cagley, J. Acharya, A.P. Klein, M. Balla, J.T. Obayashi, D. Ross, D.R. Pettersson, J.M. Pollock
Increased Notching of the Corpus Callosum in Fetal Alcohol Spectrum Disorder: A Callosal Misunderstanding?
American Journal of Neuroradiology Apr 2020, 41 (4) 725-728; DOI: 10.3174/ajnr.A6475

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Increased Notching of the Corpus Callosum in Fetal Alcohol Spectrum Disorder: A Callosal Misunderstanding?
E. Schneble, C. Lack, M. Zapadka, C.M. Pfeifer, D.M.E. Bardo, J. Cagley, J. Acharya, A.P. Klein, M. Balla, J.T. Obayashi, D. Ross, D.R. Pettersson, J.M. Pollock
American Journal of Neuroradiology Apr 2020, 41 (4) 725-728; DOI: 10.3174/ajnr.A6475
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