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Research ArticleNeurointervention

Intermixed Dimethyl-Sulfoxide–Based Nonadhesive Liquid Embolic Agents Delivered Serially via the Same Microcatheter for Cerebral AVM Treatment

A. Sirakov, K. Minkin and S. Sirakov
American Journal of Neuroradiology April 2020, 41 (4) 681-686; DOI: https://doi.org/10.3174/ajnr.A6453
A. Sirakov
aFrom the Radiology Department (A.S., S.S.)
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K. Minkin
bNeurosurgery Department (K.M.), UH St Ivan Rilski, Sofia, Bulgaria
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S. Sirakov
aFrom the Radiology Department (A.S., S.S.)
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    Fig 1.

    A 35-year-old female patient who presented with left-sided headache and seizures. DSA revealed a left parietal (A and B) AVM supplied by the left MCA. The AVM was drained by the superficial cortical vein to the superior sagittal sinus. An Apollo microcatheter was positioned into a distal arterial feeder arising from the left MCA (C). A PHIL 30 plug was created with 2 rounds of injections (D, arrows). After 1.2 mL of PHIL 30 was injected into the AVM, embolization was continued with Menox 18 (E and F) to ensure successful distal and continuous penetration. No further proximal reflux was observed (G). Note the different radiopacities of the used liquid embolic agents (black arrows, Menox 18; white arrows, PHIL 30.) At the end of the procedure, 100% size reduction was achieved by delivering a total amount of 2.7 mL of embolic material from 1 feeder during 1 session (H).

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    Fig 2.

    Step-by-step embolization of a ruptured left-sided parietal AVM, Spetzler-Martin grade II. The tip of the microcatheter was placed into the nidus (A and B). Initial injections of PHIL 30 (C, D, E, F, G, and H; arrows) were needed to create a stable proximal plug. The embolic material was switched with Menox 18 to successfully achieve distal and continuous nidal penetration (I–L; arrows). Note the distal extent of the Menox agent (M, N, arrow) and the different radio-opacities of the applied LEAs.

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    Table 1:

    Baseline characteristics of the treated patients

    VariableValue
    Age (yr)
     Mean33.5
     Median42
     Range33–61
    Sex (No.) (%)
     Male25% (4)
     Female75% (12)
    Presentation (No.) (%)
     Hemorrhage75% (12)
     Neurologic deficit–
     Headache12.5% (2)
     Epilepsy12.5% (2)
     Asymptomatic–
    Size (%) (No.)
     ≤30 mm75% (12)
     ≥30 mm25% (4)
    No. of arterial feeders (%)
     Single43.7% (7)
     Multiple56.3% (9)
    Venous pattern (No.) (%)
     Superficial68.7% (11)
     Deep18.7% (3)
     Deep and superficial12.5% (2)
    Spetzler-Martin score
     I31.2% (5)
     II37.5% (6)
     III25% (4)
     IV6.3% (1)
    mRS prior to embolization
     168.7% (11)
     225% (4)
     36.3% (1)
    • Note:—– indicates absence of particular determinant; mRS, modified ranking score.

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    Table 2:

    Embolization characteristics and technical resultsa

    Study Group (n= 16)Value
    Applied LEAPHIL 30Menox 18
    Total fluoroscopy time (sec)2460 (900–3761)
    Total injection time (sec)55 (51–70)325 (480–980)
    Time per single injection (sec)5.8 (6.6–12.1)21.1 (12–50.1)
    Injection pause time (sec)0.4 (1.1–2.2)1.1 (0.4–30)
    Injections (No.)4.1 (2–5)11 (8–35)
    Total volume of LEA per procedure (mL)0.9 (0.7–2.3)4.1 (1.2–6)
    • ↵a Data are presented as median (lower quartile; upper quartile).

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American Journal of Neuroradiology: 41 (4)
American Journal of Neuroradiology
Vol. 41, Issue 4
1 Apr 2020
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Cite this article
A. Sirakov, K. Minkin, S. Sirakov
Intermixed Dimethyl-Sulfoxide–Based Nonadhesive Liquid Embolic Agents Delivered Serially via the Same Microcatheter for Cerebral AVM Treatment
American Journal of Neuroradiology Apr 2020, 41 (4) 681-686; DOI: 10.3174/ajnr.A6453

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Intermixed Dimethyl-Sulfoxide–Based Nonadhesive Liquid Embolic Agents Delivered Serially via the Same Microcatheter for Cerebral AVM Treatment
A. Sirakov, K. Minkin, S. Sirakov
American Journal of Neuroradiology Apr 2020, 41 (4) 681-686; DOI: 10.3174/ajnr.A6453
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