Article Figures & Data
Figures
- FIG 1.
Grotta bars of the mRS score at 90 days by the 3 groups: the converters and the patients who stayed in the CS group and the GA group. The number in each bar indicates the mRS score. The odds ratio for a shift to a higher (worse) group was 2.67 for the converted group compared with the CS group.
- FIG 2.
Receiver operating characteristic (ROC) curve of the final model of the forward selection stepwise regression.
Tables
- Table 1:
Reasons for conversion among the 21 patients who were randomized to conscious sedation but converted to general anesthesia
Reason for conversion (No.) SIESTA ANSTROKE GOLIATH Total Severe agitation 7 2 3 12 Respiratory insufficiency/loss of airway 3 1 1 5 Direct puncture of the internal carotid artery 0 4 0 4 - Table 2:
Among the 185 patients allocated to conscious sedation (CS), the 21 converters are compared to the 164 who were treated under CS
CS as Treated (n = 164) Converted to GA (n = 21) P Value Hypertension 96 (59%) 12 (57%) 1.00 Diabetes 28 (17%) 5 (24%) .54 Hyperlipidemia 72 (44%) 3 (14%) .009 Smoker 38 (24%) 3 (14%) .42 Atrial fibrillation 71 (44%) 10 (48%) .82 Sex (male) 85 (52%) 10 (48%) .82 Pre-mRS (≥1) 51 (31%) 2 (10%) .042 ASPECTS (<6) 22 (14%) 1 (5%) .48 Left side affected 79 (48%) 12 (57%) .49 IV thrombolysis given 49 (30%) 4 (19%) .44 Occlusion type, ICA (neck) 12 (7%) 0 (0%) .36 ICA-T 28 (17%) 4 (19%) M1 83 (51%) 13 (62%) M2 18 (11%) 0 (0%) Tandem 23 (14%) 4 (19%) Age (mean) (SD) (yr) 71 (14) 72 (12) .58 NIHSS score on admission (mean) (SD) 17.3 (3.8) 17.8 (4.4) .27 Systolic blood pressure start EVT (mmHg), mean (SD) 165 (28) 161 (25) .55 MABP at start of EVT (mmHg), mean (SD) 113 (19) 111 (16) .62 Note:—ICA-T indicates ICA bifurcation; Pre, premorbid.
- Table 3:
Group mean of mRS at 90-day follow-up, time to groin puncture, and minimum MABP for the 3 groups–the converters, the patients who stayed in the CS group, and the GA group
Converted from CS to GA (n = 21) Stayed in CS (n = 164) GA Group (n = 183) Mean mRS (95% CI) 4.3 (3.7–4.9) 3.1 (2.8–3.4) 2.8 (2.5–3.1) Mean rate of successful reperfusion (mTICI 2b–3) (95% CI) 71.4 (47.8–88.7) 76.2 (69.0–82.5) 85.2 (79.3–90.0) Mean arrival at angiosuite to groin puncture (95% CI) (min) 25.1 (16.3–34.0) 17.7 (15.7–19.8) 24.0 (21.9–26.2) Mean groin puncture to reperfusion (95% CI) (min) 90.2 (68.8–111.6) 67.2 (59.1–75.3) 63.1 (55.7–70.4) Mean onset to reperfusion (95% CI) (min) 276 (241–312) 258 (241–275) 273 (256–290) Minimum MABP during EVT (95% CI) (mm Hg) 68.7 (62.8–74.6) 87.8 (85.7–89.9) 76.0 (74.0–78.0) Note:—mTICI indicates modified TICI.
- Table 4:
Incremental predictive value of the 4 best predictors of conversion from conscious sedation to general anesthesiaa
Incremental AUC (without Data Split) Incremental AUC (Cross-Validated) Univariable AUC (Cross-Validated) Hyperlipidemia (95% CI) 0.65 (0.56–0.73) 0.62 (0.50–0.73) 0.62 (0.50–0.73) Diabetes (95% CI) 0.68 (0.58–0.78) 0.66 (0.54–0.78) 0.49 (0.36–0.61) Pre-mRS (95% CI) 0.69 (0.60–0.79) 0.67 (0.55–0.79) 0.57 (0.45–0.69) Age (95% CI)b 0.73 (0.62–0.83) 0.62 (0.50–0.74) 0.38 (0.26–0.50) Note:—Pre indicates premorbid.
a Analysis was conducted without data splitting. Each AUC reflects the predictive power of the model consisting of the corresponding variable as well as all above variables.
↵b Not included in the final model.
