Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Getting new auth cookie, if you see this message a lot, tell someone!
Research ArticlePediatric Neuroimaging

Diffuse Leptomeningeal Glioneuronal Tumor of Childhood

D.A. Lakhani, K. Mankad, S. Chhabda, P. Feizi, R. Patel, A. Sarma and S. Pruthi
American Journal of Neuroradiology November 2020, 41 (11) 2155-2159; DOI: https://doi.org/10.3174/ajnr.A6737
D.A. Lakhani
aFrom the Department of Radiology (D.A.L., P.F.), School of Medicine, West Virginia University, Morgantown, West Virginia
bDepartment of Neuroradiology (D.A.L., P.F.), Rockefeller Neuroscience Institute, WV University, Morgantown, West Virginia
cDivision of Internal Medicine (D.A.L.), Vanderbilt University Medical Center, Nashville, Tennessee
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.A. Lakhani
K. Mankad
dDepartment of Neuroradiology (K.M., S.C.), Great Ormond Street Hospital (GOSH), London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K. Mankad
S. Chhabda
dDepartment of Neuroradiology (K.M., S.C.), Great Ormond Street Hospital (GOSH), London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Chhabda
P. Feizi
aFrom the Department of Radiology (D.A.L., P.F.), School of Medicine, West Virginia University, Morgantown, West Virginia
bDepartment of Neuroradiology (D.A.L., P.F.), Rockefeller Neuroscience Institute, WV University, Morgantown, West Virginia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P. Feizi
R. Patel
eDepartment of Diagnostic and Interventional Imaging, Section of Neuroradiology (R.P.), The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Patel
A. Sarma
fDepartment of Radiology and Radiological Sciences (A.S., S.P.), Monroe Carell Jr. Children's Hospital, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Sarma
S. Pruthi
fDepartment of Radiology and Radiological Sciences (A.S., S.P.), Monroe Carell Jr. Children's Hospital, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Pruthi
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Louis DN,
    2. Perry A,
    3. Reifenberger G, et al
    . The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 2016;131:803–20 doi:10.1007/s00401-016-1545-1 pmid:27157931
    CrossRefPubMed
  2. 2.↵
    1. Karlowee V,
    2. Kolakshyapati M,
    3. Amatya VJ, et al
    . Diffuse leptomeningeal glioneuronal tumor (DLGNT) mimicking Whipple's disease: a case report and literature review. Childs Nerv Syst 2017;33:1411–14 doi:10.1007/s00381-017-3405-2 pmid:28382437
    CrossRefPubMed
  3. 3.↵
    1. Louis DN,
    2. Ohgaki H,
    3. Wiestler OD, et al
    . The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97–109 doi:10.1007/s00401-007-0243-4 pmid:17618441
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Gardiman MP,
    2. Fassan M,
    3. Orvieto E, et al
    . Diffuse leptomeningeal glioneuronal tumors: a new entity? Brain Pathol 2010;20:361–66 doi:10.1111/j.1750-3639.2009.00285.x pmid:19486008
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Chiang JCH,
    2. Harreld JH,
    3. Orr BA, et al
    . Low-grade spinal glioneuronal tumors with BRAF gene fusion and 1p deletion but without leptomeningeal dissemination. Acta Neuropathol 2017;134:159–62 doi:10.1007/s00401-017-1728-4 pmid:28547128
    CrossRefPubMed
  6. 6.↵
    1. Lyle MR,
    2. Dolia JN,
    3. Fratkin J, et al
    . Newly identified characteristics and suggestions for diagnosis and treatment of diffuse leptomeningeal glioneuronal/neuroepithelial tumors: a case report and review of the literature. Child Neurol Open 2015;2:2329048X14567531. doi:10.1177/2329048X14567531 pmid:28503587
    CrossRefPubMed
  7. 7.↵
    1. Pellerino A,
    2. Rudà R,
    3. Bertero L, et al
    . Successful use of bevacizumab in an adult primary diffuse leptomeningeal glioneuronal tumor. J Neurosurg Sci 2018;62:229–32. doi:10.23736/S0390-5616.16.03804-2 pmid:27676284
    CrossRefPubMed
  8. 8.↵
    1. Rodriguez FJ,
    2. Perry A,
    3. Rosenblum MK, et al
    . Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity. Acta Neuropathol 2012;124:627–41 doi:10.1007/s00401-012-1037-x pmid:22941225
    CrossRefPubMed
  9. 9.↵
    1. Gardiman MP,
    2. Fassan M,
    3. Nozza P, et al
    . Diffuse leptomeningeal glioneuronal tumours: clinico-pathological follow-up. Pathologica 2012;104:428–31 doi:10.1186/s12883-015-0341-1 pmid:23547428
    CrossRefPubMed
  10. 10.↵
    1. Lee JK,
    2. Ko HC,
    3. Choi JG, et al
    . A case of diffuse leptomeningeal glioneuronal tumor misdiagnosed as chronic tuberculous meningitis without brain biopsy. Case Rep Neurol Med 2018;2018:1391943 doi:10.1155/2018/1391943 pmid:30112228
    CrossRefPubMed
  11. 11.
    1. Deng MY,
    2. Sill M,
    3. Chiang J, et al
    . Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features. Acta Neuropathol 2018;136:239–53 doi:10.1007/s00401-018-1865-4 pmid:29766299
    CrossRefPubMed
  12. 12.
    1. Schniederjan MJ,
    2. Alghamdi S,
    3. Castellano-Sanchez A, et al
    . Diffuse leptomeningeal neuroepithelial tumor: 9 pediatric cases with chromosome 1p/19q deletion status and IDH1 (R132H) immunohistochemistry. Am J Surg Pathol 2013;37:763–71 doi:10.1097/PAS.0b013e31827bf4cc pmid:23588371
    CrossRefPubMed
  13. 13.
    1. Aguilera D,
    2. Castellino RC,
    3. Janss A, et al
    . Clinical responses of patients with diffuse leptomeningeal glioneuronal tumors to chemotherapy. Childs Nerv Syst 2018;34:329–34 doi:10.1007/s00381-017-3584-x pmid:28965234
    CrossRefPubMed
  14. 14.
    1. Preuss M,
    2. Christiansen H,
    3. Merkenschlager A, et al
    . Disseminated oligodendroglial-like leptomeningeal tumors: preliminary diagnostic and therapeutic results for a novel tumor entity [corrected]. J Neurooncol 2015;124:65–74 doi:10.1007/s11060-015-1735-z pmid:25672644
    CrossRefPubMed
  15. 15.
    1. Cho HJ,
    2. Myung JK,
    3. Kim H, et al
    . Primary diffuse leptomeningeal glioneuronal tumors. Brain Tumor Pathol 2015;32:49–55 doi:10.1007/s10014-014-0187-z pmid:24770606
    CrossRefPubMed
  16. 16.
    1. Schwetye KE,
    2. Kansagra AP,
    3. McEachern J, et al
    . Unusual high-grade features in pediatric diffuse leptomeningeal glioneuronal tumor: comparison with a typical low-grade example. Hum Pathol 2017;70:105–12 doi:10.1016/j.humpath.2017.06.004 pmid:28652147
    CrossRefPubMed
  17. 17.
    1. Yamasaki T,
    2. Sakai N,
    3. Shinmura K, et al
    . Anaplastic changes of diffuse leptomeningeal glioneuronal tumor with polar spongioblastoma pattern. Brain Tumor Pathol 2018;35:209–16 doi:10.1007/s10014-018-0326-z pmid:30051174
    CrossRefPubMed
  18. 18.
    1. Fiaschi P,
    2. Badaloni F,
    3. Cagetti B, et al
    . Disseminated oligodendroglial-like leptomeningeal tumor in the adult: case report and review of the literature. World Neurosurg 2018;114:53–57 doi:10.1016/j.wneu.2018.02.160 pmid:29526778
    CrossRefPubMed
  19. 19.
    1. Tiwari S,
    2. Yadav T,
    3. Pamnani J, et al
    . Diffuse leptomeningeal glioneuronal tumor: a unique leptomeningeal tumor entity. World Neurosurg 2020;135:297–300 doi:10.1016/j.wneu.2019.12.119 pmid:31899391
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 41 (11)
American Journal of Neuroradiology
Vol. 41, Issue 11
1 Nov 2020
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Diffuse Leptomeningeal Glioneuronal Tumor of Childhood
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
D.A. Lakhani, K. Mankad, S. Chhabda, P. Feizi, R. Patel, A. Sarma, S. Pruthi
Diffuse Leptomeningeal Glioneuronal Tumor of Childhood
American Journal of Neuroradiology Nov 2020, 41 (11) 2155-2159; DOI: 10.3174/ajnr.A6737

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Diffuse Leptomeningeal Glioneuronal Tumor of Childhood
D.A. Lakhani, K. Mankad, S. Chhabda, P. Feizi, R. Patel, A. Sarma, S. Pruthi
American Journal of Neuroradiology Nov 2020, 41 (11) 2155-2159; DOI: 10.3174/ajnr.A6737
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • CASE SERIES
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Delayed diagnosis of diffuse leptomeningeal glioneuronal tumour in a young child presenting with communicating hydrocephalus
  • Uncommon Glioneuronal Tumors: A Radiologic and Pathologic Synopsis
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Frontal Paraventricular Cysts
  • Sodium MRI in Pediatric Brain Tumors
  • FRACTURE MR in Congenital Vertebral Anomalies
Show more Pediatric Neuroimaging

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire