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Research ArticleAdult Brain

Diagnosis and Prediction of Relapses in Susac Syndrome: A New Use for MR Postcontrast FLAIR Leptomeningeal Enhancement

S. Coulette, A. Lecler, E. Saragoussi, K. Zuber, J. Savatovsky, R. Deschamps, O. Gout, C. Sabben, J. Aboab, A. Affortit, F. Charbonneau and M. Obadia
American Journal of Neuroradiology July 2019, 40 (7) 1184-1190; DOI: https://doi.org/10.3174/ajnr.A6103
S. Coulette
aFrom the Neurology Department (S.C., R.D., O.G., C.S., J.A., M.O.)
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A. Lecler
bNeuroradiology Department (A.L.. E.S., J.S., F.C.)
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E. Saragoussi
bNeuroradiology Department (A.L.. E.S., J.S., F.C.)
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K. Zuber
cClinical Research Unit (K.Z.)
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J. Savatovsky
bNeuroradiology Department (A.L.. E.S., J.S., F.C.)
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R. Deschamps
aFrom the Neurology Department (S.C., R.D., O.G., C.S., J.A., M.O.)
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  • ORCID record for R. Deschamps
O. Gout
aFrom the Neurology Department (S.C., R.D., O.G., C.S., J.A., M.O.)
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C. Sabben
aFrom the Neurology Department (S.C., R.D., O.G., C.S., J.A., M.O.)
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J. Aboab
aFrom the Neurology Department (S.C., R.D., O.G., C.S., J.A., M.O.)
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A. Affortit
dOphthalmology Department (A.A.), Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
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F. Charbonneau
bNeuroradiology Department (A.L.. E.S., J.S., F.C.)
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M. Obadia
aFrom the Neurology Department (S.C., R.D., O.G., C.S., J.A., M.O.)
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REFERENCES

  1. 1.↵
    1. Susac JO,
    2. Hardman JM,
    3. Selhorst JB
    . Microangiopathy of the brain and retina. Neurology 1979;29:313–16 doi:10.1212/WNL.29.3.313 pmid:571975
    Abstract/FREE Full Text
  2. 2.↵
    1. Susac JO
    . Susac's syndrome: the triad of microangiopathy of the brain and retina with hearing loss in young women. Neurology 1994;44:591–93 doi:10.1212/WNL.44.4.591 pmid:8164809
    FREE Full Text
  3. 3.↵
    1. Papo T,
    2. Biousse V,
    3. Lehoang P, et al
    . Susac syndrome. Medicine (Baltimore) 1998;77:3–11 doi:10.1097/00005792-199801000-00002 pmid:9465860
    CrossRefPubMed
  4. 4.↵
    1. Kleffner I,
    2. Dörr J,
    3. Ringelstein M, et al
    ; European Susac Consortium (EuSaC). Diagnostic criteria for Susac syndrome. J Neurol Neurosurg Psychiatry 2016;87:1287–95 doi:10.1136/jnnp-2016-314295 pmid:28103199
    Abstract/FREE Full Text
  5. 5.↵
    1. Dörr J,
    2. Krautwald S,
    3. Wildemann B, et al
    . Characteristics of Susac syndrome: a review of all reported cases. Nat Rev Neurol 2013;9:307–16 doi:10.1038/nrneurol.2013.82 pmid:23628737
    CrossRefPubMed
  6. 6.↵
    1. Buzzard KA,
    2. Reddel SW,
    3. Yiannikas C, et al
    . Distinguishing Susac's syndrome from multiple sclerosis. J Neurol 2015;262:1613–21 doi:10.1007/s00415-014-7628-9 pmid:25547511
    CrossRefPubMed
  7. 7.↵
    1. Sarbu N,
    2. Shih RY,
    3. Jones RV, et al
    . White matter diseases with radiologic-pathologic correlation. Radiographics 2016;36:1426–47 doi:10.1148/rg.2016160031 pmid:27618323
    CrossRefPubMed
  8. 8.↵
    1. Seifert-Held T,
    2. Langner-Wegscheider BJ,
    3. Komposch M, et al
    . Susac's syndrome: clinical course and epidemiology in a Central European population. Int J Neurosci 2017;127:776–780 doi:10.1080/00207454.2016.1254631 pmid:27788613
    CrossRefPubMed
  9. 9.↵
    1. Zurawski J,
    2. Lassmann H,
    3. Bakshi R
    . Use of magnetic resonance imaging to visualize leptomeningeal inflammation in patients with multiple sclerosis: a review. JAMA Neurol 2017;74:100–09 doi:10.1001/jamaneurol.2016.4237 pmid:27893883
    CrossRefPubMed
  10. 10.↵
    1. Susac JO,
    2. Murtagh FR,
    3. Egan RA, et al
    . MRI findings in Susac's syndrome. Neurology 2003;61:1783–87 doi:10.1212/01.WNL.0000103880.29693.48 pmid:14694047
    Abstract/FREE Full Text
  11. 11.↵
    1. Sastre-Garriga J
    . Leptomeningeal enhancement in Susac's syndrome and multiple sclerosis: time to expect the unexpected? Mult Scler 2016;22:975–76 doi:10.1177/1352458516644677 pmid:27207451
    CrossRefPubMed
  12. 12.↵
    1. Engisch R,
    2. Titelbaum DS,
    3. Chilver-Stainer L, et al
    . Susac's syndrome: leptomeningeal enhancement on 3D FLAIR MRI. Mult Scler 2016;22:972–74 doi:10.1177/1352458516636836 pmid:27207452
    CrossRefPubMed
  13. 13.↵
    1. Fazekas F,
    2. Chawluk JB,
    3. Alavi A, et al
    . MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 1987;149:351–56 doi:10.2214/ajr.149.2.351 pmid:3496763
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Filippi M,
    2. Rocca MA,
    3. Ciccarelli O, et al
    ; MAGNIMS Study Group. MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines. Lancet Neurol 2016;15:292–303 doi:10.1016/S1474-4422(15)00393-2 pmid:26822746
    CrossRefPubMed
  15. 15.↵
    1. Wardlaw JM,
    2. Smith EE,
    3. Biessels GJ, et al
    ; STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1). Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 2013;12:822–38 doi:10.1016/S1474-4422(13)70124-8 pmid:23867200
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Rennebohm R,
    2. Susac JO,
    3. Egan RA, et al
    . Susac's syndrome: update. J Neurol Sci 2010;299:86–91 doi:10.1016/j.jns.2010.08.032 pmid:20855088
    CrossRefPubMed
  17. 17.↵
    R Core Team (2017). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/. Accessed December 18, 2018.
  18. 18.↵
    1. Mamourian AC,
    2. Hoopes PJ,
    3. Lewis LD
    . Visualization of intravenously administered contrast material in the CSF on fluid-attenuated inversion-recovery MR images: an in vitro and animal-model investigation. AJNR Am J Neuroradiol 2000;21:105–11 pmid:10669233
    Abstract/FREE Full Text
  19. 19.↵
    1. Mathews VP,
    2. Caldemeyer KS,
    3. Lowe MJ, et al
    . Brain: gadolinium-enhanced fast fluid-attenuated inversion-recovery MR imaging. Radiology 1999;211:257–63 doi:10.1148/radiology.211.1.r99mr25257 pmid:10189481
    CrossRefPubMed
  20. 20.↵
    1. Zivadinov R,
    2. Ramasamy DP,
    3. Hagemeier J, et al
    . Evaluation of leptomeningeal contrast enhancement using pre-and postcontrast subtraction 3D-FLAIR imaging in multiple sclerosis. AJNR Am J Neuroradiol 2018;39:642–47 doi:10.3174/ajnr.A5541 pmid:29439125
    Abstract/FREE Full Text
  21. 21.↵
    1. Latour LL,
    2. Kang DW,
    3. Ezzeddine MA, et al
    . Early blood-brain barrier disruption in human focal brain ischemia. Ann Neurol 2004;56:468–77 doi:10.1002/ana.20199 pmid:15389899
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Hamilton BE,
    2. Nesbit GM
    . Delayed CSF enhancement in posterior reversible encephalopathy syndrome. AJNR Am J Neuroradiol 2008;29:456–57 doi:10.3174/ajnr.A0926 pmid:18184835
    Abstract/FREE Full Text
  23. 23.↵
    1. Naul LG,
    2. Finkenstaedt M
    . Extensive cerebrospinal fluid enhancement with gadopentetate dimeglumine in a primitive neuroectodermal tumor. AJNR Am J Neuroradiol 1997;18:1709–11 pmid:9367319
    Abstract
  24. 24.↵
    1. Salvarani C,
    2. Brown RD Jr.,
    3. Calamia KT, et al
    . Primary central nervous system vasculitis with prominent leptomeningeal enhancement: a subset with a benign outcome. Arthritis Rheum 2008;58:595–603 doi:10.1002/art.23300 pmid:18240248
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Wengert O,
    2. Rothenfusser-Korber E,
    3. Vollrath B, et al
    . Neurosarcoidosis: correlation of cerebrospinal fluid findings with diffuse leptomeningeal gadolinium enhancement on MRI and clinical disease activity. J Neurol Sci 2013;335:124–30 doi:10.1016/j.jns.2013.09.008 pmid:24071064
    CrossRefPubMed
  26. 26.↵
    1. Absinta M,
    2. Cortese ICM,
    3. Vuolo L, et al
    . Leptomeningeal gadolinium enhancement across the spectrum of chronic neuroinflammatory diseases. Neurology 2017;88:1439–44 doi:10.1212/WNL.0000000000003820 pmid:28283598
    Abstract/FREE Full Text
  27. 27.↵
    1. Absinta M,
    2. Vuolo L,
    3. Rao A, et al
    . Gadolinium-based MRI characterization of leptomeningeal inflammation in multiple sclerosis. Neurology 2015;85:18–28 doi:10.1212/WNL.0000000000001587 pmid:25888557
    Abstract/FREE Full Text
  28. 28.↵
    1. Zivadinov R,
    2. Uher T,
    3. Hagemeier J, et al
    . A serial 10-year follow-up study of brain atrophy and disability progression in RRMS patients. Mult Scler 2016;22:1709–18 doi:10.1177/1352458516629769 pmid:26883943
    CrossRefPubMed
  29. 29.↵
    1. Kim W,
    2. Lee JE,
    3. Kim SH, et al
    . Cerebral cortex involvement in neuromyelitis optica spectrum disorder. J Clin Neurol 2016;12:188–93 doi:10.3988/jcn.2016.12.2.188 pmid:26833983
    CrossRefPubMed
  30. 30.↵
    1. White ML,
    2. Zhang Y,
    3. Smoker WRK
    . Evolution of lesions in Susac syndrome at serial MR imaging with diffusion-weighted imaging and apparent diffusion coefficient values. AJNR Am J Neuroradiol 2004;25:706–13 pmid:15140708
    Abstract/FREE Full Text
  31. 31.↵
    1. Hardy TA,
    2. O'Brien B,
    3. Gerbis N, et al
    . Brain histopathology in three cases of Susac's syndrome: implications for lesion pathogenesis and treatment. J Neurol Neurosurg Psychiatry 2015;86:582–84 doi:10.1136/jnnp-2014-308240 pmid:25168394
    FREE Full Text
  32. 32.↵
    1. McLeod DS,
    2. Ying HS,
    3. McLeod CA, et al
    . Retinal and optic nerve head pathology in Susac's syndrome. Ophthalmology 2011;118:548–52 doi:10.1016/j.ophtha.2010.07.012 pmid:20920828
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Magro CM,
    2. Poe JC,
    3. Lubow M, et al
    . Susac syndrome: an organ-specific autoimmune endotheliopathy syndrome associated with anti-endothelial cell antibodies. Am J Clin Pathol 2011;136:903–12 doi:10.1309/AJCPERI7LC4VNFYK pmid:22095376
    CrossRefPubMed
  34. 34.↵
    1. Egan RA,
    2. Hills WL,
    3. Susac JO
    . Gass plaques and fluorescein leakage in Susac syndrome. J Neurol Sci 2010;299:97–100 doi:10.1016/j.jns.2010.08.043 pmid:20880549
    CrossRefPubMed
  35. 35.↵
    1. Garg N,
    2. Reddel SW,
    3. Miller DH, et al
    . The corpus callosum in the diagnosis of multiple sclerosis and other CNS demyelinating and inflammatory diseases. J Neurol Neurosurg Psychiatry 2015;86:1374–82 doi:10.1136/jnnp-2014-309649 pmid:25857658
    Abstract/FREE Full Text
  36. 36.↵
    1. Barkhof F,
    2. Filippi M,
    3. Miller DH, et al
    . Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain J Neurol 1997;120(Pt 11):2059–69 doi:10.1093/brain/120.11.2059 pmid:9397021
    CrossRefPubMedWeb of Science
  37. 37.↵
    1. Paty DW,
    2. Li DK
    . Interferon beta-1b is effective in relapsing-remitting multiple sclerosis, II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial—UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group. Neurology 1993;43:662–67 doi:10.1212/WNL.43.4.662 pmid:8469319
    Abstract/FREE Full Text
  38. 38.↵
    1. Eisele P,
    2. Griebe M,
    3. Szabo K, et al
    . Investigation of leptomeningeal enhancement in MS: a postcontrast FLAIR MRI study. Neurology 2015;84:770–75 doi:10.1212/WNL.0000000000001286 pmid:25616480
    CrossRefPubMed
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Cite this article
S. Coulette, A. Lecler, E. Saragoussi, K. Zuber, J. Savatovsky, R. Deschamps, O. Gout, C. Sabben, J. Aboab, A. Affortit, F. Charbonneau, M. Obadia
Diagnosis and Prediction of Relapses in Susac Syndrome: A New Use for MR Postcontrast FLAIR Leptomeningeal Enhancement
American Journal of Neuroradiology Jul 2019, 40 (7) 1184-1190; DOI: 10.3174/ajnr.A6103

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Diagnosis and Prediction of Relapses in Susac Syndrome: A New Use for MR Postcontrast FLAIR Leptomeningeal Enhancement
S. Coulette, A. Lecler, E. Saragoussi, K. Zuber, J. Savatovsky, R. Deschamps, O. Gout, C. Sabben, J. Aboab, A. Affortit, F. Charbonneau, M. Obadia
American Journal of Neuroradiology Jul 2019, 40 (7) 1184-1190; DOI: 10.3174/ajnr.A6103
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