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Figures
- Fig 1.
Angiograms with H&E-stained tissue sections. Elastase-induced aneurysm (A) on the day of platinum coil embolization and ear wound creation. Angiogram of coiled aneurysm at 14 days (B) with a corresponding ear wound (C, H&E, magnification ×100), macro image of the ear wound on day of sacrifice (D, ruler markings are in centimeters, the smallest ticks in millimeters). Angiogram of 30-day coiled aneurysm (E) with corresponding aneurysm (F, H&E, magnification ×200). Note diffuse, dense myofibroblast (long, spindle-shaped) proliferation in both H&E photomicrographs.
- Fig 2.
Gene expression data from aneurysms and cutaneous ear wounds after 24 hours (24H), 5 days (5D), and 14 days (14D). Data were normalized to GAPDH and displayed as a fold change relative to normal tissues (left carotid artery or contralateral ear, respectively) from the same animal (P = .0422 in D) (n = 3 animals, 3 experimental replicates). PDGF indicates platelet-derived growth factor; VEGF, vascular endothelial growth factor; MMP9, matrix metalloproteinase 9; 30D, 30 days.
Tables
Genes important in cutaneous wound healing
Wound-Healing Phase Time Cell Types Key Molecules Inflammation 0 min to 6 days Platelets, monocytes, neutrophils, macrophages, and T-lymphocytes PDGF, TGFβ1, VEGF, CD86, CD206 Proliferation 24 hr to weeks Fibroblasts, endothelial cells, keratinocytes TGFβ1, VEGF, PDGF, MMP9, CD86, CD206 Remodeling 4 days to months Fibroblasts PDGF, TGFβ1, SMA1, CD206
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