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Figures
- Fig 1.
MR imaging measurements of the optic nerve area. Coronal inversion recovery image through the orbits approximately midway between the orbital apex and globes. The measurement of the cross-sectional area of the right optic nerve (excluding the optic nerve sheath) is shown using a freeform ROI measurement tool on the PACS. The left optic nerve is not outlined for comparison.
- Fig 2.
ROC curve showing the ability of ONarea to predict the diagnosis of optic nerve atrophy. The ROC curve shows the ability to distinguish 34 affected eyes from 90 healthy eyes on the basis of the ONarea. Using a threshold MR imaging–measured ONarea ≤ 4.0 mm2 yields a sensitivity of 0.85, specificity of 0.83, and an AUC of 0.91.
- Fig 3.
The relationship between MR imaging–measured optic nerve area and OCT-measured RNFL thickness. The scatterplot demonstrates a positive correlation between MR imaging–measured optic nerve area and OCT-measured RNFL thickness in patients with optic nerve atrophy. Circle data points denote those eyes with a clinical diagnosis of optic nerve atrophy. Triangle data points denote the unaffected eyes in the patient population (correlation coefficient r = 0.68; 95% CI, 0.50–0.80; P < .001).
Tables
Comparison of MRI-measured optic nerve area between patients' affected and unaffected eyes and healthy eyes of controls and comparison of RNFL thickness between patients' affected and unaffected eyesa
Optic Nerves Patients' Affected (n = 34) Patients' Unaffected (n = 18) Healthy (n = 90) RNFL (μm) 67.12 ± 13.55 94.00 ± 8.66 NA Pp < .001 Optic nerve area (mm2) 3.09 ± 1.09 5.27 ± 1.39 6.27 ± 2.64 Pp = .008 Pc < .001 Puc = .21 Note:—NA indicates not applicable; Pc, comparison between patients' affected optic nerves and control optic nerves; Pp, comparison between patients' affected and unaffected optic nerves; Puc, comparison between patients' unaffected optic nerves and control optic nerves.
↵a Data are mean ± SD unless otherwise indicated. No OCT data were available for the 90 healthy eyes in the control population because these individuals did not have clinical symptoms to warrant OCT measurement.
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