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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleFunctional
Open Access

Resting-State Functional Connectivity of the Middle Frontal Gyrus Can Predict Language Lateralization in Patients with Brain Tumors

S. Gohel, M.E. Laino, G. Rajeev-Kumar, M. Jenabi, K. Peck, V. Hatzoglou, V. Tabar, A.I. Holodny and B. Vachha
American Journal of Neuroradiology February 2019, 40 (2) 319-325; DOI: https://doi.org/10.3174/ajnr.A5932
S. Gohel
aFrom the Department of Health Informatics (S.G.), Rutgers University School of Health Professions, Newark, New Jersey
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M.E. Laino
bDepartments of Radiology (M.E.L., M.J., K.P., V.H., A.I.H., B.V.)
eDepartment of Radiology (M.E.L.), Catholic University of the Sacred Heart, Rome, Italy
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G. Rajeev-Kumar
fIcahn School of Medicine at Mount Sinai (G.R.-K.), New York, New York.
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M. Jenabi
bDepartments of Radiology (M.E.L., M.J., K.P., V.H., A.I.H., B.V.)
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K. Peck
bDepartments of Radiology (M.E.L., M.J., K.P., V.H., A.I.H., B.V.)
cMedical Physics (K.P.)
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V. Hatzoglou
bDepartments of Radiology (M.E.L., M.J., K.P., V.H., A.I.H., B.V.)
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V. Tabar
dNeurosurgery (V.T.), Memorial Sloan Kettering Cancer Center, New York, New York
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A.I. Holodny
bDepartments of Radiology (M.E.L., M.J., K.P., V.H., A.I.H., B.V.)
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B. Vachha
bDepartments of Radiology (M.E.L., M.J., K.P., V.H., A.I.H., B.V.)
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    Fig 1.

    A, Broca area and middle frontal gyrus masks overlaid on the Montreal Neurological Institute standard brain. B, ICA maps representing the BA network are overlaid on the BA/MFG masks for a representative subject. C, ICA maps representing the MFG network are overlaid on the BA/MFG masks for a representative subject.

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    Fig 2.

    Scatterplot between the percentage of BA voxels and the percentage of middle frontal gyrus voxels across participants. Significant correlation was observed between the percentage of MFG and BA voxels across patients.

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    Fig 3.

    Scatterplot of the LIs in the middle frontal gyrus versus the BA. A significant positive correlation was observed between the LI of MFG and BA regions.

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    Fig 4.

    Group-level functional connectivity between the bilateral BA and MFG regions across patients. Positive functional connectivity was observed between the bilateral BA and bilateral MFG regions.

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American Journal of Neuroradiology: 40 (2)
American Journal of Neuroradiology
Vol. 40, Issue 2
1 Feb 2019
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Cite this article
S. Gohel, M.E. Laino, G. Rajeev-Kumar, M. Jenabi, K. Peck, V. Hatzoglou, V. Tabar, A.I. Holodny, B. Vachha
Resting-State Functional Connectivity of the Middle Frontal Gyrus Can Predict Language Lateralization in Patients with Brain Tumors
American Journal of Neuroradiology Feb 2019, 40 (2) 319-325; DOI: 10.3174/ajnr.A5932

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Resting-State Functional Connectivity of the Middle Frontal Gyrus Can Predict Language Lateralization in Patients with Brain Tumors
S. Gohel, M.E. Laino, G. Rajeev-Kumar, M. Jenabi, K. Peck, V. Hatzoglou, V. Tabar, A.I. Holodny, B. Vachha
American Journal of Neuroradiology Feb 2019, 40 (2) 319-325; DOI: 10.3174/ajnr.A5932
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