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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleInterventional

Percutaneous CT-Guided Skull Biopsy: Feasibility, Safety, and Diagnostic Yield

A. Tomasian, T.J. Hillen and J.W. Jennings
American Journal of Neuroradiology February 2019, 40 (2) 309-312; DOI: https://doi.org/10.3174/ajnr.A5949
A. Tomasian
aFrom the Department of Radiology (A.T.), University of Southern California, Los Angeles, California
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T.J. Hillen
bMallinckrodt Institute of Radiology (T.J.H., J.W.J.), St. Louis, Missouri.
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J.W. Jennings
bMallinckrodt Institute of Radiology (T.J.H., J.W.J.), St. Louis, Missouri.
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    Fig 1.

    A 58-year-old woman with a history of index finger chondrosarcoma and a right frontal bone mass. Axial CT (A) and FDG-PET/CT (B) images show an aggressive permeative and hypermetabolic bone marrow–replacing lesion in the right frontal bone with an aggressive periosteal reaction (A and B, arrow). Axial CT image during percutaneous biopsy (C) shows positioning of a coaxial bone-biopsy needle within the lesion. The total conscious sedation time was 29 minutes, and histologic evaluation confirmed intraosseous meningioma.

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    Fig 2.

    A 65-year-old man with poorly differentiated salivary gland sarcomatoid carcinoma with a left temporal bone lesion. Axial T1-weighted MR imaging (A), CT (B), and technetium 99m methylene diphosphonate SPECT-CT (C) images show an osteolytic bone marrow–replacing lesion with increased radiopharmaceutical uptake in the petrous portion of the left temporal bone (A–C, arrow). Note the surrounding vital tissues. Coronal CT image (D) during percutaneous biopsy shows coaxial positioning of a soft-tissue biopsy needle, through an OnControl bone introducer cannula, within the lesion through the mastoid air cells. The total conscious sedation time was 40 minutes, and histologic evaluation confirmed metastasis from a known primary salivary gland tumor.

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  • Details of skull lesions, biopsy parameters, and final diagnosisa

    Patient No.Anatomic SiteTumor Size (mm)Tumor FeatureBiopsy NeedleSpecimen No.Core Length (mm)Final Diagnosis
    1Right frontal50 × 46 × 22PermeativeBone320Intraosseous meningioma
    2Left frontal13 × 9 × 5OsteolyticBone110Blood products and benign tissue
    Soft tissue210
    3Left frontal61 × 42 × 13OsteoblasticBone72–10B-cell lymphoma
    4Right frontal9 × 9 × 5OsteolyticBone16Hemangioma
    Soft tissue15
    5Left frontal11 × 10 × 4OsteolyticBone15Benign bone and soft tissue
    Soft tissue210
    6Skull base and occipitalDiffuseMixedBone, soft tissue615–20Fibrous dysplasia
    7Left temporal19 × 14 × 10OsteolyticBone115Metastatic salivary sarcomatoid carcinoma
    Soft tissue120
    8Right temporal21 × 15 × 7OsteolyticSoft tissue510–20Plasmocytoma
    9Left parietal38 × 34 × 10MixedBone110Metastatic breast carcinoma
    Soft tissue120
    10Right occipital12 × 8 × 8OsteolyticBone120Osteonecrosis
    11Left occipital27 × 20 × 19OsteolyticSoft tissue220Metastatic thyroid carcinoma
    12Right parietal24 × 18 × 13MixedBone24–6Metastatic breast carcinoma
    13Left parietalMost of parietal bonePermeativeBone15Radiation-induced sarcoma
    Soft tissue610–20
    14Left frontal27 × 17 × 14OsteoblasticBone215Xanthoma with osteosclerosis
    • ↵a Data for patients 3 and 6 have been previously published.8

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American Journal of Neuroradiology: 40 (2)
American Journal of Neuroradiology
Vol. 40, Issue 2
1 Feb 2019
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Cite this article
A. Tomasian, T.J. Hillen, J.W. Jennings
Percutaneous CT-Guided Skull Biopsy: Feasibility, Safety, and Diagnostic Yield
American Journal of Neuroradiology Feb 2019, 40 (2) 309-312; DOI: 10.3174/ajnr.A5949

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Percutaneous CT-Guided Skull Biopsy: Feasibility, Safety, and Diagnostic Yield
A. Tomasian, T.J. Hillen, J.W. Jennings
American Journal of Neuroradiology Feb 2019, 40 (2) 309-312; DOI: 10.3174/ajnr.A5949
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