Article Figures & Data
Figures
- Fig 1.
Histology of H3-K27M and wild-type diffuse midline gliomas. Hematoxylin and eosin (H&E) and antihistone H3-K27M immunohistochemistry of diffuse intrinsic pontine gliomas with H3-K27M mutation (A) and histone H3 wildtype (B). 400x magnification.
- Fig 2.
Diffusion characteristics of diffuse midline gliomas based on the presence of the H3-K27M mutation. Tumor 3D volume segmented from the FLAIR image (A) was coregistered onto the ADC map. Voxel-based histogram of tumor (B). Normal distribution curves are superimposed on the ADC histograms.
- Fig 3.
Voxel-based 3D whole-tumor ADC boxplots comparing histone H3-K27M and wild-type tumors without a difference in ADCmean (A), ADCmedian (B), and ADCmin (10−6mm2/s) (C).
- Fig 4.
ADC histogram descriptive statistics of diffuse midline gliomas. No difference in skewness, kurtosis, and variance between wildtype and histone H3-K27M mutant tumors (A). Examples of histogram parameters of ADC (10−6mm2/s) (B). Normal distribution curves are superimposed on the ADC histograms.
- Fig 5.
Comparison of diffusion characteristics between diffuse midline gliomas centered within the pons (top) and hemispheric glioblastomas centered within right frontal lobe (bottom) (A). Boxplot comparison of mean and median ADC shows higher ADC (10−6mm2/s) in diffuse midline gliomas compared with hemispheric glioblastomas (B).
- Fig 6.
Kaplan-Meier survival curve based on histone H3-K27M mutation status (A) and ADC (10−6mm2/s) being below the 1.1 × 10−3mm2/s cutoff (B). Boxplots of ADC mean and median comparing patients with overall survival <12 months and ≥12 months (C and D).
Tables
Patient demographics
All Patients (n = 31) Histone H3-K27M (n = 23) Histone H3 Wild-Type (n = 8) Male 22 14 8 Age (mean) (range) (yr) 9.8 (0.45–21.7) 8.9 (0.45–19.3) 12.5 (0.68–21.7) Tumor location Pons/vermis/4th ventricle 21 17 4 Thalamus 7 5 2 Tectum 2 0 2 Subcallosal 1 1 0
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